Jing Chen, Ph.D.

Primary Areas of Research

• Genetics of Type 1 Diabetes
• Interaction between genomic and mitochondrial genomes in the pathogenesis of Type 1 Diabetes
• Role of mitochondrial function in pancreatic beta cells
• Role of T-cell mitochondrial function during development of autoimmune Type 1 Diabetes

Publications

• Chen J, Grieshaber S, Mathews CE (2011). Methods to assess beta cell death mediated by cytotoxic T lymphocytes. J Vis Exp. Jun 16;(52). pii: 2724. doi: 10.3791/2724.
• Chen J, Gusdon AM, Mathews CE (2011). Role of genetics in resistance to type 1 diabetes.  Diabetes/Metabolism Research & Review.  Nov;27(8):849-53
• Chen J, Gusdon AM, Piganelli JD, Leiter EH, Mathews CE (2011).  mt-Nd2^a modifies resistance against autoimmune Type 1 diabetes in NOD mice at the level of the pancreatic beta cell. Diabetes. 60(1):355-9.
• Lightfoot YL, Chen J, Mathews CE (2011).  Role of the Mitochondria in Immune-Mediated Apoptotic Death of the Human Pancreatic β Cell Line βLox5. PLoS One. 6(6):e20617. Epub 2011 Jun 27.
• Gusdon AM, Chen J, Votyakova TV, Mathews CE (2009). Quantification, localization, and tissue specificities of mouse mitochondrial reactive oxygen species production. Methods Enzymol. 456:439-57.
• Chen J, Gusdon AM, Thayer TC, Mathews CE (2008). Role of increased ROS dissipation in prevention of T1D: Lessons from the ALR mouse.  Ann N Y Acad Sci. Dec; 1150:157-66.
• Chen J, Lu Y, Lee C-H, Li RH, Leiter EH, Mathews CE (2008). Comparative Genetics of Spontaneous Autoimmune versus Chemically-Induced Diabetes in Mice. Free Radic Biol Med. Nov 1;45(9):1263-70
• Chen J, Hatori, Y, Nakajima K, Eizawa T, Ehara T, Koyama M, Hirai T, Fukuda Y, Kinoshita M, Suguyama A, Hayashi J-I, Onaya T, Kobayashi T, Tawata M (2006).  Mitochondrial complex I activity is significantly decreased in a patient with maternally inherited type 2 diabetes mellitus and hypertrophic cardiomyopathy associated with mitochondrial DNA C3310T mutation: a cybrid study.  Diabetes Res Clin Pract.  Nov;74(2):148-53
• Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH (2006). Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol. Apr 15;176(8):4590-9.
• Chen J, Reifsnyder PC, Scheuplein F, Schott WH, Mileikovsky M, Soodeen-Karamath S, Nagy A, Dosch HM, Ellis J, Koch-Nolte F, Leitei EH (2005). “Agouti NOD”: Identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells” Mammalian Genome. Oct;16(10):775-83