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Marguerite Hatch, B.Sc., Ph.D.

ProfessorMarguerite Hatch, B.Sc., Ph.D. UF Department of Pathology, Immunology and Laboratory Medicine
College of Medicine
P.O. Box 100275
Gainesville, FL 32610

Office Location and Express Mail
UF Department of Pathology, Immunology and Laboratory Medicine
College of Medicine

1395 Center Drive, D6-33A
Gainesville, FL 32610

Office Contact: Karen Cox
  • Phone: 352.294.5593

Dr. Hatch’s general interests are focused on the mechanisms and control of electrolyte and solute transport across epithelial membranes. She is particularly interested in transport mechanisms for the oxalate anion across intestinal and renal epithelial in the context of calcium oxalate kidney stone disease and primary hyperoxaluria.

Current investigations in Dr. Hatch’s laboratory are focused on several anion exchangers in the SLC26A gene family that are involved in epithelial oxalate transport. Using a variety of transport physiology and molecular biology approaches and studies that include whole animal (mouse knockout models) and tissue (intestine and kidney), in addition to cell culture studies, her team evaluates the contribution of specific transport proteins to epithelial movements of oxalate. Dr. Hatch also focuses on the physiological interaction between the gut-resident oxalobacter formigenes and the enterocyte, which results in alterations of intestinal oxalate transport and enteric elimination of oxalate and leads to reduced renal excretion of this stone-forming compound.

Curriculum Vitae


Publications

  • Hatch, M.  2014.  Intestinal Adaptations in Chronic Kidney Disease and the Influence of Gastric Bypass Surgery.  Exp. Physiol (under review).
  • Canales, B.K. and Hatch, M.  2014.  Kidney stone incidence and metabolic urinary changes after modern bariaric surgery: Review of clinical studies, experimental studies, and preventative methods.  Surg. Obes. Rel. Dis. oxalate.  (in press).
  • Freel, R.W., Whittamore, J.M., and Hatch, M.  2013.  Transcellular oxalate and chloride absorption in the mouse intestine are mediated by the DRA anion exchanger (Slc26a3) and urinary oxalate excretion decreases in DRA knockout mice. Am. J. Physiol.  Gastrointest. Liver Physiol epub 06/25/2013.
  • Hatch, M., and Freel, R.W.  2013.  A human strain of Oxalobacter (HC-1) promotes enteric oxalate secretion in the small intestine of mice and reduces urinary oxalate excretion.  Urolithiasis. 41(5):379-84, 2013.
  • Whittamore, J.M., Freel, R.W., and Hatch, M.  2013.  Sulfate secretion and chloride absorption are mediated by the anion exchanger DRA (Slc26a3) in the mouse caecum.  Am. J. Physiol.  Gastrointest. Liver Physiol.  Jul 15;305(2):G172-84.
  • Canales, BK, Ellen, J., Khan, S.R., and Hatch, M.  2013  Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate. J Urol. Sep;190(3):1102-9
  • Freel, R.W., and Hatch, M.  2012.  Hyperoxaluric Rats Do Not Exhibit Alterations in Renal Expression Patterns of Slc26a1 (SAT1) mRNA or Protein.  Urol Res. 40:647-654
  • Li, N., Hatch, M., Wasserfall, C., Douglas-Escobar, M., Atkinson, M., Schatz, D., and Neu, J. Butyrate and Type 1 Diabetes: Can We Fix the Intestinal Leak? 2010. J. Ped. Gastro. & Nutr. Liver Physiol. 297: G918-G929
  • Freel, R.W., Morozumi, M., and Hatch, M.  2009.  Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26a6 reveals the role and properties of PAT-1.  Am. J. Physiol.  Gastrointest. Liver Physiol. 297: G918-G929.
  • Hatch, M., Gjymishka, A., Salido, E.C., Allison, M.J., and Freel, R.W. Enteric oxalate elimination is induced and oxalate is normalized in a mouse model of Primary Hyperoxaluria following intestinal colonization with Oxalobacter. 2011. Am. J. Physiol. Gastrointest. Liver Physiol. 300: G461-G469.
  • Freel, R.W., Morozumi, M., and Hatch, M. 2009. Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26a6 reveals the role and properties of PAT-1. Am. J. Physiol. Gastrointest. Liver Physiol. 297: G918-G929.
  • Hatch, M., and Freel, R.W. Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism. 2008. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G348-G356.
  • Freel, R.W., and Hatch, M. Enteric oxalate secretion is not directly mediated by the human CFTR chloride channel. 2008. Urol Res. 36: 127-131.
  • Hatch, M., and Freel, R.W. 2008. The roles and mechanisms of intestinal oxalate transport and oxalate homeostasis. Sem in Neph. 28 #2:143-151.
  • Hatch, M., Cornelius, J., Allison, M., Sidhu, H., Peck, A, and Freel, R.W. 2006. Oxalobacter sp. reduces urinary oxalate excretion by promoting enteric oxalate secretion. Kid. Int. 69 #4: 691-8.
  • Freel, R.W., Hatch, M., Green, M., and Soleimani, M. 2006. Ileal oxalate absorption and urinary oxalate excretion are enhanced in slc26a6-null mice. Amer. J. Physiol. (Gastro.): 290 #4:G716-28.
  • Green, M., and Freel, R.W., and Hatch, M. 2005. Lipid peroxidation is not the underlying cause of renal injury in hyperoxaluric rats. Kid. Int. 68 #6: 2629-2638.
  • Green, M., Hatch, M., and Freel, R.W. 2005. Ethylene Glycol Induces Hyperoxaluria Without Metabolic Acidosis in Rats. Am. J. Physiol. (Renal) 289 #3: F536-F543.
  • Neu, J., Reverte, C. M., Mackey, A. D., Liboni, K., Tuhacek-Tenace, L. M., Hatch, M., et al. 2005. Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes. J. Pediatr. Gastroenterol. Nutr. 40 (#5): 589-95
  • Hatch, M. and Freel, R.W. 2005. Intestinal transport of an obdurate anion: oxalate. Urol. Res. 33: 1-16.
  • Morozumi, M, Green, M., Freel, R.W. and Hatch, M. 2004. The effect of oxalate loading or acidified media on the expression of mRNA encoding candidate oxalate transporters. Proceedings of the 10th International Symposium on Urolithiasis in Hong Kong pp 178-180.
  • Harris, A., Freel, R.W, and Hatch, M. 2004. Serum oxalate concentrations in rats and humans as determined with the use of ion chromatography. J.Lab.Clin. Med. 144, #1, 45-52.
  • Hatch, M. and Freel, R.W. 2003. Angiotensin II Involvement in Enteric Oxalate Excretion in Rats with Chronic Renal Failure Induced by Hyperoxaluria. Urol. Res. 31: 426-432.