Experimental Pathology
Experimental pathology involves the study of disease processes via the examination of cells, tissues or organs or bodily fluids from diseased organisms. The Department’s Experimental Pathology Division is composed of a diverse group of investigators who research the disease mechanisms. Their research covers five overlapping areas, including:
Cancer Research
Breast • Pancreas • Liver • Colorectal • Lung • Multiple Myeloma • Lung • Prostate
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Emerging Pathogens
Research interests include:
- HIV pathogenesis
- HCV pathogenesis and therapeutic approaches
- Antibiotic resistance in enteric bacteria
- Modeling of pathogen evolution Molecular docking approach to drug design
- Vaccine design
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Immunology/Autoimmunity
The goal of our research is to understand the contribution of immune system to disease; to define mechanisms of disease; discover biomarkers; and develop effective treatments.
Our disease-related studies include basic and clinical research on all aspects of the immune system in:
- Lupus;
- Type-1 diabetes;
- Viral infections; and
- Cancer.
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Nephrolithiasis
This specialty focuses on investigating the fundamental mechanisms responsible for the formation of kidney stones to better manage and prevent kidney stone disease. As most kidney stones are composed of calcium oxalate, a concerted effort is to understand the pathophysiological aspects of high urinary oxalate excretion, considered an important risk factor in the development of kidney stones.
Currently, our researchers investigate:
- Intestinal oxalate transport;
- Immune response to viral infection;
- The role of gastrointestinal bacterium, oxalobacter formigenes, in regulating oxalate homeostasis through catabolizing ingested oxalate; and
- The relationship between oxalate-induced oxidative stress and kidney stone-induced inflammation of the kidney.
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Stem Cell Research
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