Title: Roles of the Insulin-like Growth Factor Axis in Pre-Type 1 Diabetes Immune Regulation
Type 1 Diabetes (T1D) is an autoimmune disorder in which impairments in immune regulation permit the destruction of the insulin-producing pancreatic beta cells. The goals of this proposal are to evaluate whether the expression or bioavailability of insulin-like growth factors (IGF), potent immune modulating hormones, are altered in the development of T1D and to determine how IGFs may be used to resolve known T1D-associated immune regulatory deficits.
https://bruskolab.diabetes.ufl.edu/staff-profiles/graduate-students/melanie-shapiro/