Allison M Andrews

Allison M Andrews,

Associate Professor

Department: MD-PATHOLOGY-GENERAL
Business Phone: (352) 294-5275
Business Email: andrews.allison@ufl.edu

Teaching Profile

Courses Taught
2024
GMS5905 Special Topics in Biomedical Sciences

Publications

Academic Articles
2024
Effects of Drag-Reducing Polymers on Hemodynamics and Whole Blood-Endothelial Interactions in 3D-Printed Vascular Topologies.
ACS applied materials & interfaces. 16(12):14457-14466 [DOI] 10.1021/acsami.3c17099. [PMID] 38488736.
2024
Engineered Dual Antioxidant Enzyme Complexes Targeting ICAM-1 on Brain Endothelium Reduce Brain Injury-Associated Neuroinflammation.
Bioengineering (Basel, Switzerland). 11(3) [DOI] 10.3390/bioengineering11030200. [PMID] 38534474.
2023
A Next-Generation 3D Tissue-Engineered Model of the Human Brain Microvasculature to Study the Blood-Brain Barrier.
Bioengineering (Basel, Switzerland). 10(7) [DOI] 10.3390/bioengineering10070817. [PMID] 37508844.
2023
Activation of CB2R by synthetic CB2R agonist, PM289, improves brain endothelial barrier properties, decreases inflammatory response and enhances endothelial repair.
NeuroImmune pharmacology and therapeutics. 2(4):387-400 [DOI] 10.1515/nipt-2023-0016. [PMID] 38116176.
2023
An Engineered Adeno-Associated Virus Capsid Mediates Efficient Transduction of Pericytes and Smooth Muscle Cells of the Brain Vasculature.
Human gene therapy. 34(15-16):682-696 [DOI] 10.1089/hum.2022.211. [PMID] 37376759.
2021
ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood brain barrier modulation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 41(9):2242-2255 [DOI] 10.1177/0271678X20984976. [PMID] 33583260.
2021
Extracellular Microvesicles Released From Brain Endothelial Cells are Detected in Animal Models Of HIV-1 Signifying Unresolved Inflammation.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 16(4):785-795 [DOI] 10.1007/s11481-021-10008-5. [PMID] 34435263.
2021
SARS-CoV-2 Spike Protein Disrupts Blood-Brain Barrier Integrity via RhoA Activation.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 16(4):722-728 [DOI] 10.1007/s11481-021-10029-0. [PMID] 34687399.
2021
The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties.
Journal of neuroinflammation. 18(1) [DOI] 10.1186/s12974-021-02116-z. [PMID] 33648543.
2021
The Use of Tissue Engineering to Fabricate Perfusable 3D Brain Microvessels in vitro.
Frontiers in physiology. 12 [DOI] 10.3389/fphys.2021.715431. [PMID] 34531761.
2020
Experimental Traumatic Brain Injury during Adolescence Enhances Cocaine Rewarding Efficacy and Dysregulates Dopamine and Neuroimmune Systems in Brain Reward Substrates.
Journal of neurotrauma. 37(1):27-42 [DOI] 10.1089/neu.2019.6472. [PMID] 31347447.
2020
Reward and immune responses in adolescent females following experimental traumatic brain injury.
Behavioural brain research. 379 [DOI] 10.1016/j.bbr.2019.112333. [PMID] 31682867.
2020
The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier.
Neurobiology of disease. 146 [DOI] 10.1016/j.nbd.2020.105131. [PMID] 33053430.
2019
Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury.
Frontiers in neurology. 10 [DOI] 10.3389/fneur.2019.00582. [PMID] 31275220.
2018
Characterization of human fetal brain endothelial cells reveals barrier properties suitable for in vitro modeling of the BBB with syngenic co-cultures.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 38(5):888-903 [DOI] 10.1177/0271678X17708690. [PMID] 28534661.
2018
Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers.
Fluids and barriers of the CNS. 15(1) [DOI] 10.1186/s12987-018-0104-7. [PMID] 29960602.
2017
Acute administration of catalase targeted to ICAM-1 attenuates neuropathology in experimental traumatic brain injury.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-03309-4. [PMID] 28630485.
2017
Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-03027-x. [PMID] 28578388.
2017
Cholesterol Enrichment Impairs Capacitative Calcium Entry, eNOS Phosphorylation & Shear Stress-Induced NO Production.
Cellular and molecular bioengineering. 10(1):30-40 [DOI] 10.1007/s12195-016-0456-5. [PMID] 28138348.
2017
Dexamethasone Attenuates the Enhanced Rewarding Effects of Cocaine Following Experimental Traumatic Brain Injury.
Cell transplantation. 26(7):1178-1192 [DOI] 10.1177/0963689717714341. [PMID] 28933216.
2017
Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells.
Journal of neurochemistry. 140(2):216-230 [DOI] 10.1111/jnc.13861. [PMID] 27718541.
2016
Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain Injury.
Frontiers in cellular neuroscience. 10 [DOI] 10.3389/fncel.2016.00043. [PMID] 26973460.
2016
Microparticle-Induced Activation of the Vascular Endothelium Requires Caveolin-1/Caveolae.
PloS one. 11(2) [DOI] 10.1371/journal.pone.0149272. [PMID] 26891050.
2016
Neuregulin1-β decreases interleukin-1β-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability.
Journal of neurochemistry. 136(2):250-7 [DOI] 10.1111/jnc.13374. [PMID] 26438054.
2015
Identification and dynamic regulation of tight junction protein expression in human neural stem cells.
Stem cells and development. 24(12):1377-89 [DOI] 10.1089/scd.2014.0497. [PMID] 25892136.
2014
Shear stress-induced NO production is dependent on ATP autocrine signaling and capacitative calcium entry.
Cellular and molecular bioengineering. 7(4):510-520 [PMID] 25386222.
2013
Fluid shear stress induces the clustering of heparan sulfate via mobility of glypican-1 in lipid rafts.
American journal of physiology. Heart and circulatory physiology. 305(6):H811-20 [DOI] 10.1152/ajpheart.00764.2012. [PMID] 23851278.
2011
Glycated collagen alters endothelial cell actin alignment and nitric oxide release in response to fluid shear stress.
Journal of biomechanics. 44(10):1927-35 [DOI] 10.1016/j.jbiomech.2011.04.026. [PMID] 21555127.
2010
Direct, real-time measurement of shear stress-induced nitric oxide produced from endothelial cells in vitro.
Nitric oxide : biology and chemistry. 23(4):335-42 [DOI] 10.1016/j.niox.2010.08.003. [PMID] 20719252.

Grants

Jun 2024 ACTIVE
Synthetic fentanyls adversely affect the blood-brain barrier and HIV replication in the context of neuroHIV
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Jun 2024 ACTIVE
Innovative In-Situ Imaging Techniques for the Visualization of CNS associated HIV reservoirs in the Context of Substance Abuse
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Oct 2023 ACTIVE
HIV and Cocaine Drive Bone-Marrow Blood (BMB) Barrier Dysfunction and Altered Hematopoietic Stem Cell (HSC) Differentiation Leading to Cardiovascular Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH via NATL INST OF HLTH NIDA
Sep 2023 ACTIVE
The role of cannabinoids in the regulation of the blood brain barrier in the context of NeuroHIV and anti-retroviral therapy
Role: Co-Investigator
Funding: TEMPLE UNIVERSITY via NATL INST OF HLTH NIDA

Contact Details

Phones:
Business:
(352) 294-5275
Emails:
Addresses:
Business Mailing:
PO Box 100275
GAINESVILLE FL 32610
Business Street:
d6 18B Pathology
1395 Center Dr
Gainesville FL 32610