Maigan A Brusko,
RES AST SCTST
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-4331-2202
Areas of Interest
- Autoimmune Disease
- Immune Tolerance
- Immune-Mediated Disease
- Immunology of Type 1 diabetes
- Type 1 Diabetes
Publications
2024
Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.02.08.579175.
[PMID] 38405840.
2024
Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes.
Diabetes care.
47(2):285-289
[DOI] 10.2337/dc23-1750.
[PMID] 38117469.
2023
A genomic data archive from the Network for Pancreatic Organ donors with Diabetes.
Scientific data.
10(1)
[DOI] 10.1038/s41597-023-02244-6.
[PMID] 37237059.
2023
Data-driven selection of analysis decisions in single-cell RNA-seq trajectory inference.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.12.18.572214.
[PMID] 38187768.
2023
Human immune phenotyping reveals accelerated aging in type 1 diabetes
JCI Insight.
8(17)
[DOI] 10.1172/jci.insight.170767.
[PMID] 37498686.
2023
Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity.
Nature immunology.
24(8):1370-1381
[DOI] 10.1038/s41590-023-01557-3.
[PMID] 37460638.
2023
Site-specific development and progressive maturation of human tissue-resident memory TÂ cells over infancy and childhood.
Immunity.
56(8):1894-1909.e5
[DOI] 10.1016/j.immuni.2023.06.008.
[PMID] 37421943.
2023
Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase.
Nature biomedical engineering.
7(9):1156-1169
[DOI] 10.1038/s41551-023-01025-1.
[PMID] 37127708.
2022
Membrane marker selection for segmenting single cell spatial proteomics data.
Nature communications.
13(1)
[DOI] 10.1038/s41467-022-29667-w.
[PMID] 35422106.
2021
A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.696536.
[PMID] 34484194.
2021
Anatomical structures, cell types and biomarkers of the Human Reference Atlas.
Nature cell biology.
23(11):1117-1128
[DOI] 10.1038/s41556-021-00788-6.
[PMID] 34750582.
2021
geneBasis: an iterative approach for unsupervised selection of targeted gene panels from scRNA-seq.
Genome biology.
22(1)
[DOI] 10.1186/s13059-021-02548-z.
[PMID] 34872616.
2021
Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex.
Cell reports.
37(9)
[DOI] 10.1016/j.celrep.2021.110071.
[PMID] 34852222.
2021
Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling
Science Immunology.
6(66)
[DOI] 10.1126/sciimmunol.abj0789.
[PMID] 34890254.
2021
SARS-CoV-2 infection generates tissue-localized immunological memory in humans
Science Immunology.
6(65)
[DOI] 10.1126/sciimmunol.abl9105.
[PMID] 34618554.
2021
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Shock (Augusta, Ga.).
55(5):587-595
[DOI] 10.1097/SHK.0000000000001671.
[PMID] 33021571.
2020
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.00611.
[PMID] 32351504.
2020
Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.01289.
[PMID] 32670283.
2020
Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.574447.
[PMID] 33193362.
2020
Innate inflammation drives NK cell activation to impair Treg activity.
Journal of autoimmunity.
108
[DOI] 10.1016/j.jaut.2020.102417.
[PMID] 32035746.
2019
Dendritic Cells Treated with Exogenous Indoleamine 2,3-Dioxygenase Maintain an Immature Phenotype and Suppress Antigen-specific T cell Proliferation.
Journal of immunology and regenerative medicine.
5
[DOI] 10.1016/j.regen.2019.100015.
[PMID] 31788580.
2017
An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis.
Biomaterials.
143:79-92
[DOI] 10.1016/j.biomaterials.2017.07.029.
[PMID] 28772190.
2016
Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
Diabetes.
65(12):3765-3775
[PMID] 27669730.
2015
Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.
The Journal of clinical investigation.
125(1):448-55
[DOI] 10.1172/JCI78492.
[PMID] 25500887.
2013
Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
19(7):1126-9
[DOI] 10.1016/j.bbmt.2013.04.011.
[PMID] 23611977.
2013
Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.
The Journal of clinical investigation.
123(12):5310-8
[DOI] 10.1172/JCI70314.
[PMID] 24231351.
2013
The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.
Journal of autoimmunity.
44:8-12
[DOI] 10.1016/j.jaut.2013.06.001.
[PMID] 23891168.
2012
Central role for interleukin-2 in type 1 diabetes.
Diabetes.
61(1):14-22
[DOI] 10.2337/db11-1213.
[PMID] 22187370.
2011
Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide.
Diabetes care.
34(12):2567-9
[DOI] 10.2337/dc11-1406.
[PMID] 22011412.
2011
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950).
186(7):3918-26
[DOI] 10.4049/jimmunol.1003099.
[PMID] 21368230.
2009
Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
PloS one.
4(11)
[DOI] 10.1371/journal.pone.0007980.
[PMID] 19956753.
Grants
Oct 2023
ACTIVE
Network for Pancreatic Organ Donors – nPOD
Role: Co-Investigator
Funding: JDRF
Sep 2023
ACTIVE
Combinational immune therapies with antigen-specific Tregs for tolerance induction in islet transplantation
Role: Co-Investigator
Funding: JDRF
Jun 2023
ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Feb 2023
ACTIVE
Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Dec 2022
ACTIVE
Human Atlas of Neonatal Development and Early Life-Immunity (HANDEL-I) continuation
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Oct 2022
– Aug 2023
Combinational immune therapies with antigen-specific Tregs for tolerance induction in islet transplantation
Role: Principal Investigator
Funding: UNIV OF MIAMI
via JDRF
Mar 2022
– Feb 2024
Evolution of T cell immunity in blood and tissues over childhood
Role: Principal Investigator
Funding: COLUMBIA UNIVERSITY MEDICAL CENTER
via NATL INST OF HLTH NIAID
Dec 2021
ACTIVE
Expansion of Pancreatlas connectivity platform and phenotyping of HANDEL samples by cutting-edge single cell multi-ome technology
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER
via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Sep 2021
ACTIVE
Co-registration of Cell Organization, Phenotype and Function in the Human Pancreas During Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Aug 2021
ACTIVE
Human Pancreas Analysis Program (HPAP)
Role: Co-Investigator
Funding: UNIV OF PENNSYLVANIA
via NATL INST OF HLTH NIDDK
May 2021
ACTIVE
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Oct 2020
ACTIVE
Multi-omic 3D tissue maps for a Human BioMolecular Atlas
Role: Co-Investigator
Funding: PACIFIC NW NATL LAB
via NATL INST OF HLTH NIDDK
Feb 2020
– Jan 2023
Human Atlas of Neonatal Developmental and Early Life Pancreas / Immunity (HANDEL)-P/I Continuation
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Contact Details
Phones:
- Business:
- (352) 273-9299
Emails:
- Business:
- maigan@ufl.edu
Addresses:
- Business Mailing:
-
PO BOX 116131
GAINESVILLE FL 326110001 - Business Street:
-
1275 Center Drive BMSB J542
Gainesville FL 32610