Martha Campbell-Thompson

Martha Campbell-Thompson,

Professor

Department: MD-PATHOLOGY
Business Phone: (352) 273-6129
Business Email: mct@ufl.edu

About Martha Campbell-Thompson

Martha Campbell-Thompson, D.V.M., Ph.D, serves as the Pathology Core Principal Investigator at the University of Florida, where she earned doctorates in veterinary medicine and veterinary physiology. A board certified large animal veterinary surgeon, Dr. Campbell-Thompson moved into basic research after receiving her Ph.D. She has over 20 years experience in animal models of human disease with an emphasis on type 1 diabetes. She brings managerial experience to her role as primary administrator of the Pathology Core, providing histological and immunolocalization services to over 100 investigators at the University of Florida, in the United States, and overseas. In collaboration with Dr. Atkinson’s group, Dr. Campbell-Thompson has become the lead pathologist for all rodent and human type 1 diabetes studies.

Accomplishments

nPOD Founding Investigator Award
2018 · JDRF
Graduate research award
1988 · University of Florida, Charles F. Simpson Memorial Scholarship
Graduate Research Award
1987 · Comparative Gastroenterology Society
Graduate Student Award
1987 · Comparative Gastroenterology Society
Fellow
1986 · American College of Veterinary Surgeons
Large Animal Resident of the Year
1984 · University of Florida College of Veterinary Medicine
Large Animal Resident of the Year
1983 · University of Florida College of Veterinary Medicine

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-6878-1235

Areas of Interest
  • Adeno-Associated Viral Gene Therapy
  • Beta cell biology
  • Beta cell regeneration for Type 1 Diabetes
  • Islet inflammation
  • Neuromodulation of beta cell function

Publications

2021
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.
Diabetes. 70(4):944-954 [DOI] 10.2337/db20-0995. [PMID] 33441381.
2021
Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas.
The American journal of pathology. 191(3):454-462 [DOI] 10.1016/j.ajpath.2020.11.010. [PMID] 33307036.
2021
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-85659-8. [PMID] 33753784.
2021
Pancreas Optical Clearing and 3-D Microscopy in Health and Diabetes.
Frontiers in endocrinology. 12 [DOI] 10.3389/fendo.2021.644826. [PMID] 33981285.
2021
What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series.
Molecular metabolism. [DOI] 10.1016/j.molmet.2021.101323. [PMID] 34416394.
2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.02180. [PMID] 33013915.
2020
Designing a bioelectronic treatment for Type 1 diabetes: targeted parasympathetic modulation of insulin secretion.
Bioelectronics in medicine. 3(2):17-31 [DOI] 10.2217/bem-2020-0006. [PMID] 33169091.
2020
Exocrine Pancreas Dysfunction in Type 1 Diabetes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 26(12):1505-1513 [DOI] 10.4158/EP-2020-0295. [PMID] 33471743.
2020
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Cell metabolism. 32(6):1041-1051.e6 [DOI] 10.1016/j.cmet.2020.11.005. [PMID] 33207244.
2020
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association. 37(12):2160-2168 [DOI] 10.1111/dme.14361. [PMID] 32634859.
2020
Large-scale electron microscopy database for human type 1 diabetes.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-16287-5. [PMID] 32424134.
2020
Loss of RE-1 silencing transcription factor accelerates exocrine damage from pancreatic injury.
Cell death & disease. 11(2) [DOI] 10.1038/s41419-020-2269-7. [PMID] 32080178.
2020
Organisation of the human pancreas in health and in diabetes.
Diabetologia. 63(10):1966-1973 [DOI] 10.1007/s00125-020-05203-7. [PMID] 32894306.
2020
Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues.
Diabetes. 69(1):60-66 [DOI] 10.2337/db19-0554. [PMID] 31597639.
2019
Islet amyloidosis in a child with type 1 diabetes.
Islets. 11(2):44-49 [DOI] 10.1080/19382014.2019.1599707. [PMID] 31084520.
2019
Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 67(1):41-52 [DOI] 10.1369/0022155418778546. [PMID] 29771178.
2019
Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.
Diabetes care. 42(2):281-287 [DOI] 10.2337/dc18-1512. [PMID] 30552130.
2018
High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network.
Journal of visualized experiments : JoVE. (131) [DOI] 10.3791/56859. [PMID] 29443037.
2018
Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-03367-w. [PMID] 29491378.
2018
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism. 103(1):35-45 [DOI] 10.1210/jc.2017-01159. [PMID] 28938416.
2018
The Role of Accessory Cells in Islet Homeostasis.
Current diabetes reports. 18(11) [DOI] 10.1007/s11892-018-1096-z. [PMID] 30267158.
2018
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Cell reports. 22(10):2667-2676 [DOI] 10.1016/j.celrep.2018.02.032. [PMID] 29514095.
2017
5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency.
Molecular therapy : the journal of the American Society of Gene Therapy. 25(6):1387-1394 [DOI] 10.1016/j.ymthe.2017.03.029. [PMID] 28408179.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine. 23(2) [DOI] 10.1038/nm0217-264a. [PMID] 28170374.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine. 23(8) [DOI] 10.1038/nm0817-1004a. [PMID] 28777787.
2017
Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.
Pancreas. 46(2):252-259 [DOI] 10.1097/MPA.0000000000000717. [PMID] 27984510.
2017
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes.
Diabetes care. 40(9):e122-e123 [DOI] 10.2337/dc17-0996. [PMID] 28679687.
2017
Immunohistochemistry Staining for Human Alpha-1 Antitrypsin.
Methods in molecular biology (Clifton, N.J.). 1639:139-143 [DOI] 10.1007/978-1-4939-7163-3_13. [PMID] 28752453.
2017
Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus.
Diabetes care. 40(5):723-725 [DOI] 10.2337/dc16-2127. [PMID] 28428323.
2017
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.
Diabetes. 66(3):722-734 [DOI] 10.2337/db16-1025. [PMID] 27920090.
2017
Periodic Acid-Schiff Staining with Diastase.
Methods in molecular biology (Clifton, N.J.). 1639:145-149 [DOI] 10.1007/978-1-4939-7163-3_14. [PMID] 28752454.
2017
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Cell metabolism. 26(3):568-575.e3 [DOI] 10.1016/j.cmet.2017.08.013. [PMID] 28877460.
2017
Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?
Diabetologia. 60(4):753-755 [DOI] 10.1007/s00125-016-4195-x. [PMID] 28070616.
2017
Response to Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 2017;40:723-725.
Diabetes care. 40(10) [DOI] 10.2337/dci17-0030. [PMID] 28931713.
2017
Serum Trypsinogen Levels in Type 1 Diabetes.
Diabetes care. 40(4):577-582 [DOI] 10.2337/dc16-1774. [PMID] 28115475.
2016
Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.
Human pathology. 56:93-100 [DOI] 10.1016/j.humpath.2016.06.006. [PMID] 27342911.
2016
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine. 22(12):1482-1487 [DOI] 10.1038/nm.4203. [PMID] 27798614.
2016
Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(2):983-93 [DOI] 10.1096/fj.15-279810. [PMID] 26546129.
2016
Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes.
Diabetes care. 39(9):1650-2 [DOI] 10.2337/dc16-0711. [PMID] 27555624.
2016
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
Diabetes. 65(3):719-31 [DOI] 10.2337/db15-0779. [PMID] 26581594.
2016
Pancreatic duct hyperplasia/dysplasia in type 1 diabetes and pancreatic weight in individuals with and without diabetes. Reply to Kobayashi T, Aida K, Fukui T et al [letter] and Saisho Y [letter].
Diabetologia. 59(4):870-2 [DOI] 10.1007/s00125-016-3889-4. [PMID] 26861059.
2016
Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets.
Diabetes care. 39(7):1292-4 [DOI] 10.2337/dc16-0737. [PMID] 27330131.
2016
Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 77:21-8 [DOI] 10.1016/j.jcv.2016.01.015. [PMID] 26875099.
2016
The influence of type 1 diabetes on pancreatic weight.
Diabetologia. 59(1):217-221 [DOI] 10.1007/s00125-015-3752-z. [PMID] 26358584.
2016
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.
JCI insight. 1(20) [DOI] 10.1172/jci.insight.88242. [PMID] 27942583.
2015
A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.
Scientific reports. 5 [DOI] 10.1038/srep13155. [PMID] 26279095.
2015
Abnormalities of the Exocrine Pancreas in Type 1 Diabetes.
Current diabetes reports. 15(10) [DOI] 10.1007/s11892-015-0653-y. [PMID] 26318606.
2015
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Diabetes. 64(11):3873-84 [DOI] 10.2337/db15-0164. [PMID] 26185279.
2015
Organ donor specimens: What can they tell us about type 1 diabetes?
Pediatric diabetes. 16(5):320-30 [DOI] 10.1111/pedi.12286. [PMID] 25998576.
2015
Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes.
PloS one. 10(8) [DOI] 10.1371/journal.pone.0135663. [PMID] 26302420.
2014
New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.
Current diabetes reports. 14(10) [DOI] 10.1007/s11892-014-0530-0. [PMID] 25142715.
2014
The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.
Pediatric diabetes. 15(1):1-9 [DOI] 10.1111/pedi.12097. [PMID] 24325575.
2013
Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.
The Journal of clinical investigation. 123(12):5310-8 [DOI] 10.1172/JCI70314. [PMID] 24231351.
2013
Increased complement activation in human type 1 diabetes pancreata.
Diabetes care. 36(11):3815-7 [DOI] 10.2337/dc13-0203. [PMID] 24041678.
2013
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors.
Diabetes. 62(7):2595-604 [DOI] 10.2337/db12-1686. [PMID] 23524641.
2013
Reponse To Comments On: Butler Et Al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595-2604
Diabetes. 62:E19-E22 [DOI] 10.2337/db13-0996. [PMID] 24065800.
2013
Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604.
Diabetes. 62(10):e19-22 [DOI] 10.2337/db13-0996. [PMID] 24065800.
2013
The diagnosis of insulitis in human type 1 diabetes.
Diabetologia. 56(11):2541-3 [DOI] 10.1007/s00125-013-3043-5. [PMID] 24006089.
2012
Alpha-1 Antitrypsin (Aat) Expression 1 Year After Im Administration of Raav1-Cb-Haat in a Phase 2 Clinical Trial
Molecular Therapy. 20:S91-S92
2012
Collection protocol for human pancreas.
Journal of visualized experiments : JoVE. (63) [DOI] 10.3791/4039. [PMID] 22665046.
2012
Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.
Neurobiology of learning and memory. 97(1):69-80 [DOI] 10.1016/j.nlm.2011.09.006. [PMID] 21982980.
2012
Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis.
American journal of physiology. Gastrointestinal and liver physiology. 302(3):G296-308 [DOI] 10.1152/ajpgi.00562.2010. [PMID] 22114116.
2012
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.
Diabetes/metabolism research and reviews. 28(7):608-17 [DOI] 10.1002/dmrr.2316. [PMID] 22585677.
2012
Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.
JAMA. 308(22):2337-9 [DOI] 10.1001/jama.2012.15008. [PMID] 23232891.
2012
Staining protocols for human pancreatic islets.
Journal of visualized experiments : JoVE. (63) [DOI] 10.3791/4068. [PMID] 22665223.
2011
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
Journal of translational medicine. 9 [DOI] 10.1186/1479-5876-9-21. [PMID] 21345239.
2011
Clinical Manifestations of Heterozygous Expression of a Mutation That Causes Glycogen Storage Disease Type Ia in Dogs
Journal of Veterinary Internal Medicine. 25:731-732
2011
Glycogen storage disease type Ia in canines: a model for human metabolic and genetic liver disease.
Journal of biomedicine & biotechnology. 2011 [DOI] 10.1155/2011/646257. [PMID] 21318173.
2011
N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance.
American journal of respiratory cell and molecular biology. 44(6):824-30 [DOI] 10.1165/rcmb.2009-0285OC. [PMID] 20693405.
2011
Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results.
Human gene therapy. 22(10):1239-47 [DOI] 10.1089/hum.2011.053. [PMID] 21609134.
2011
Salivary PYY: a putative bypass to satiety.
PloS one. 6(10) [DOI] 10.1371/journal.pone.0026137. [PMID] 22028819.
2011
Selective stimulation of VEGFR2 accelerates progressive renal disease.
The American journal of pathology. 179(1):155-66 [DOI] 10.1016/j.ajpath.2011.03.024. [PMID] 21640973.
2011
The pancreas in human type 1 diabetes.
Seminars in immunopathology. 33(1):29-43 [DOI] 10.1007/s00281-010-0208-x. [PMID] 20495921.
2010
Adeno-associated virus-mediated correction of a canine model of glycogen storage disease type Ia.
Human gene therapy. 21(7):903-10 [DOI] 10.1089/hum.2009.157. [PMID] 20163245.
2010
Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells.
Cancer biology & therapy. 10(8):758-64 [PMID] 20699653.
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2010
Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis.
The journal of gene medicine. 12(1):35-44 [DOI] 10.1002/jgm.1409. [PMID] 19866480.
2010
Diabetic eNOS-knockout mice develop accelerated retinopathy.
Investigative ophthalmology & visual science. 51(10):5240-6 [DOI] 10.1167/iovs.09-5147. [PMID] 20435587.
2010
Dimorphic histopathology of long-standing childhood-onset diabetes.
Diabetologia. 53(4):690-8 [DOI] 10.1007/s00125-009-1642-y. [PMID] 20062967.
2010
Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney.
The American journal of pathology. 176(5):2198-208 [DOI] 10.2353/ajpath.2010.090316. [PMID] 20363914.
2010
Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy. 18(8):1553-8 [DOI] 10.1038/mt.2010.116. [PMID] 20551917.
2010
Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.
Journal of diabetes and its complications. 24(3):163-7 [DOI] 10.1016/j.jdiacomp.2008.12.004. [PMID] 19217320.
2010
Gel-mediated delivery of AAV1 vectors corrects ventilatory function in Pompe mice with established disease.
Molecular therapy : the journal of the American Society of Gene Therapy. 18(3):502-10 [DOI] 10.1038/mt.2009.305. [PMID] 20104213.
2010
Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Diabetologia. 53(10):2198-204 [DOI] 10.1007/s00125-010-1829-2. [PMID] 20593162.
2010
Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
American journal of physiology. Renal physiology. 298(3):F609-16 [DOI] 10.1152/ajprenal.00377.2009. [PMID] 20015944.
2009
Amelioration of Insulitis and Reversal of Diabetes in Nod Mice By Murine Anti-Thymocyte Globulin and Granulocyte-Colony Stimulating Factor Combination Therapy
Clinical Immunology. 131:S48-S49 [DOI] 10.1016/j.clim.2009.03.137.
2009
Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse.
American journal of physiology. Renal physiology. 296(2):F317-27 [DOI] 10.1152/ajprenal.90450.2008. [PMID] 19036847.
2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes. 58(10):2277-84 [DOI] 10.2337/db09-0557. [PMID] 19628781.
2009
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
The American journal of pathology. 174(4):1221-9 [DOI] 10.2353/ajpath.2009.080605. [PMID] 19246639.
2009
Modulation of Long-Term Feeding Behavior and Social Interactions Using Non-Invasive Gene Therapy With Recombinant Aav Vectors
Molecular Therapy. 17
2009
Network for Pancreatic Organ Donors With Diabetes (Npod): Donor Demographics and Early Progress Report
Hormone Research. 72:156-157
2009
Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.
Diabetologia. 52(2):262-70 [DOI] 10.1007/s00125-008-1200-z. [PMID] 19002428.
2009
Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
Journal of immunology (Baltimore, Md. : 1950). 182(8):4608-15 [DOI] 10.4049/jimmunol.0713269. [PMID] 19342635.
2009
Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery.
Molecular therapy : the journal of the American Society of Gene Therapy. 17(1):81-7 [DOI] 10.1038/mt.2008.217. [PMID] 18941444.
2009
Systemic Expression of Transgene Product Is Not Required for Induction of Immune Tolerance By Aav2 Hepatic Gene Transfer
Molecular Therapy. 17
2009
The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/- -dependent allergy mouse model.
Gene therapy. 16(2):172-83 [DOI] 10.1038/gt.2008.156. [PMID] 18818669.
2008
Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD.
Human gene therapy. 19(6):579-88 [DOI] 10.1089/hum.2007.168. [PMID] 18500942.
2008
Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
Annals of the New York Academy of Sciences. 1150:152-6 [DOI] 10.1196/annals.1447.049. [PMID] 19120286.
2008
Gene delivery to intestinal epithelial cells in vitro and in vivo with recombinant adeno-associated virus types 1, 2 and 5.
Digestive diseases and sciences. 53(5):1261-70 [PMID] 17934813.
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2008
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes. 57(2):405-14 [PMID] 18039815.
View on: PubMed
2008
p53 regulates FAK expression in human tumor cells.
Molecular carcinogenesis. 47(5):373-82 [PMID] 17999388.
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2008
Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene.
The journal of gene medicine. 10(1):51-60 [PMID] 18023072.
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2008
Recombinant adeno-associated virus-mediated gene delivery of long chain acyl coenzyme A dehydrogenase (LCAD) into LCAD-deficient mice.
The journal of gene medicine. 10(10):1113-23 [DOI] 10.1002/jgm.1242. [PMID] 18720429.
2008
The Pivotal Role of Vegf On Glomerular Macrophage Infiltration in Advanced Diabetic Nephropathy
Modern Pathology. 88(3):949-961 [DOI] 10.1038/labinvest. [PMID] 24336072.
2008
The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.
Laboratory investigation; a journal of technical methods and pathology. 88(9):949-61 [DOI] 10.1038/labinvest.2008.60. [PMID] 18607348.
2007
Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7(5):1112-20 [PMID] 17456199.
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2007
Alpha1-antitrypsin protects beta-cells from apoptosis.
Diabetes. 56(5):1316-23 [PMID] 17360983.
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2007
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.
Journal of the American Society of Nephrology : JASN. 18(2):539-50 [PMID] 17202420.
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2007
Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol.
Journal of molecular endocrinology. 39(4):223-37 [PMID] 17909263.
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2007
Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats.
American journal of physiology. Endocrinology and metabolism. 293(3):E726-36 [PMID] 17578883.
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2007
In vitro studies of steroid hormones in neurofibromatosis 1 tumors and Schwann cells.
Molecular carcinogenesis. 46(7):512-23 [PMID] 17393410.
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2007
In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA.
Laboratory investigation; a journal of technical methods and pathology. 87(9):893-902 [PMID] 17592477.
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2007
Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and dissemination of vector genomes to distant sites.
Human gene therapy. 18(3):245-56 [PMID] 17376008.
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2006
Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
Human gene therapy. 17(6):625-34 [PMID] 16776571.
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2006
Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
Diabetes. 55(7):1939-45 [PMID] 16804061.
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2006
Long-term monitoring of transplanted islets using positron emission tomography.
Molecular therapy : the journal of the American Society of Gene Therapy. 14(6):851-6 [PMID] 16982215.
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2006
Noninvasive imaging of islet grafts using positron-emission tomography.
Proceedings of the National Academy of Sciences of the United States of America. 103(30):11294-9 [PMID] 16868090.
View on: PubMed
2006
Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector.
The journal of gene medicine. 8(6):730-5 [PMID] 16518879.
View on: PubMed
2005
Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.
Journal of virology. 79(2):1045-52 [PMID] 15613333.
View on: PubMed
2005
Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector.
Molecular therapy : the journal of the American Society of Gene Therapy. 12(5):867-75 [PMID] 16085464.
View on: PubMed
2005
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Human gene therapy. 16(2):235-47 [PMID] 15761263.
View on: PubMed
2005
Expression of the ammonia transporter proteins Rh B glycoprotein and Rh C glycoprotein in the intestinal tract.
American journal of physiology. Gastrointestinal and liver physiology. 288(5):G1036-47 [PMID] 15576624.
View on: PubMed
2005
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America. 102(20):7251-6 [PMID] 15878989.
View on: PubMed
2005
Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
Molecular therapy : the journal of the American Society of Gene Therapy. 12(3):519-27 [PMID] 15979413.
View on: PubMed
2005
Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system.
Molecular therapy : the journal of the American Society of Gene Therapy. 12(6):1217-25 [PMID] 16213797.
View on: PubMed
2005
Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.
Transplantation. 80(4):530-3 [PMID] 16123729.
View on: PubMed
2004
Bioluminescent monitoring of islet graft survival after transplantation.
Molecular therapy : the journal of the American Society of Gene Therapy. 9(3):428-35 [PMID] 15006610.
View on: PubMed
2004
Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.
The American journal of pathology. 165(3):1045-53 [PMID] 15331427.
View on: PubMed
2004
Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity.
Gene therapy. 11(3):233-40 [PMID] 14737082.
View on: PubMed
2004
Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice.
Gene therapy. 11(2):181-6 [PMID] 14712302.
View on: PubMed
2003
Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.
Diabetes. 52(3):708-16 [PMID] 12606512.
View on: PubMed
2003
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats.
Proceedings of the National Academy of Sciences of the United States of America. 100(24):14217-22 [PMID] 14617771.
View on: PubMed
2003
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950). 171(5):2270-8 [PMID] 12928371.
View on: PubMed
2002
Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.
Transplantation. 74(8):1184-6 [PMID] 12438968.
View on: PubMed
2002
Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell adhesion proteins in human uterine RL95-2 cells.
Biochemical and biophysical research communications. 294(1):101-7 [PMID] 12054747.
View on: PubMed
2002
Intramuscular administration of recombinant adeno-associated virus 2 alpha-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic aspects.
Molecular therapy : the journal of the American Society of Gene Therapy. 6(3):329-35 [PMID] 12231168.
View on: PubMed
2001
Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America. 98(24):13913-8 [PMID] 11717448.
View on: PubMed
2001
Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer.
Cancer research. 61(2):632-40 [PMID] 11212261.
View on: PubMed
2001
Immunolocalization of estrogen receptor alpha and beta in gastric epithelium and enteric neurons.
The Journal of endocrinology. 171(1):65-73 [PMID] 11572791.
View on: PubMed
2001
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
Gene therapy. 8(17):1343-6 [PMID] 11571571.
View on: PubMed
1999
17Beta-estradiol modulates gastroduodenal preneoplastic alterations in rats exposed to the carcinogen N-methyl-N’-nitro-nitrosoguanidine.
Endocrinology. 140(10):4886-94 [PMID] 10499548.
View on: PubMed
1998
Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta.
The American journal of physiology. 274(3):C603-14 [DOI] 10.1152/ajpcell.1998.274.3.C603. [PMID] 9530091.
1997
Estrogen receptor alpha and beta expression in upper gastrointestinal tract with regulation of trefoil factor family 2 mRNA levels in ovariectomized rats.
Biochemical and biophysical research communications. 240(2):478-83 [PMID] 9388504.
View on: PubMed
1995
In situ hybridization of H-K-ATPase beta-subunit mRNA in rat and rabbit kidney.
The American journal of physiology. 269(3 Pt 2):F345-54 [PMID] 7573483.
View on: PubMed
1995
Induction and immunolocalization of manganese superoxide dismutase in acute acetic acid-induced colitis in the rat.
Gastroenterology. 109(3):800-11 [PMID] 7657108.
View on: PubMed
1995
Regulation of manganese superoxide dismutase during acute colitis: specific induction in rat colonic glandular epithelium, smooth muscle, and myenteric neurons
Gastroenterology. 109:800-812
1994
Secretagogue-induced [14C]aminopyrine uptake in isolated equine parietal cells.
American journal of veterinary research. 55(1):132-7 [PMID] 7511358.
View on: PubMed
1993
Canine parietal cell binding by antibodies to the complementary peptide of somatostatin.
The American journal of the medical sciences. 305(6):365-73 [PMID] 8099469.
View on: PubMed
1992
Complementary peptide to the carboxyl-terminal tetrapeptide of gastrin.
Gastroenterology. 103(3):749-58 [PMID] 1499924.
View on: PubMed
1990
Basal and pentagastrin-stimulated gastric secretion in young horses.
The American journal of physiology. 259(6 Pt 2):R1259-66 [PMID] 2260736.
View on: PubMed
1989
Effect of butorphanol on equine antroduodenal motility.
Equine veterinary journal. Supplement. (7):21-3 [PMID] 9118100.
View on: PubMed
1989
Effect of xylazine treatment on equine proximal gastrointestinal tract myoelectrical activity.
American journal of veterinary research. 50(6):945-9 [PMID] 2764348.
View on: PubMed
1989
Upper gastrointestinal surgery for ulcer disease in foals.
The Veterinary clinics of North America. Equine practice. 5(2):351-62 [PMID] 2670112.
View on: PubMed
1987
Effect of ranitidine on gastric acid secretion in young male horses.
American journal of veterinary research. 48(10):1511-5 [PMID] 3674562.
View on: PubMed
1986
Gastroenterostomy for treatment of gastroduodenal ulcer disease in 14 foals.
Journal of the American Veterinary Medical Association. 188(8):840-4 [PMID] 3710873.
View on: PubMed

Grants

Sep 2021 ACTIVE
Natural History and Mechanisms of Exocrine Pancreatic Dysfunction in Pre-Type 1 Diabetes
Role: Other
Funding: NATL INST OF HLTH NIDDK
Oct 2020 ACTIVE
Multi-omic 3D tissue maps for a Human BioMolecular Atlas
Role: Co-Investigator
Funding: PACIFIC NW NATL LAB via NATL INST OF HLTH NIDDK
Sep 2020 ACTIVE
Type 1 Diabetes in Acute Pancreatitis Consortium – Clinical Centers
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Aug 2020 ACTIVE
Understanding pancreatic endocrine and exocrine loss in pre-type 1 diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Feb 2020 ACTIVE
Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes
Role: Principal Investigator
Funding: BATTELLE MEMORIAL INST via NATL INST OF HLTH NIDDK
Jul 2019 ACTIVE
Zip Proteins and Iron Metabolism
Role: Other
Funding: NATL INST OF HLTH NIDDK
Nov 2018 – Aug 2020
Neural regulation of alpha cell function and dysregulation in type 1 diabetes
Role: Principal Investigator
Funding: JDRF
Sep 2018 ACTIVE
2/3 Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity Center
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jun 2018 ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2018 ACTIVE
Network for Pancreatic Organ Donors – nPOD
Role: Co-Investigator
Funding: JDRF
Jan 2018 – Mar 2021
Collaborative Type 1 Diabetes Research Project: The Network for Pancreatic Organ donors with Diabetes (nPOD)
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jan 2017 – Mar 2021
Cognitive Augmentation through Neuroplasticity (CAN)
Role: Project Manager
Funding: US DEPT OF DEFENSE DARPA
Sep 2016 – Jul 2020
Neuromodulation-based treatment of diabetes: identifying anatomical and physiological pancreatic innervation targets
Role: Principal Investigator
Funding: NATL INST OF HLTH OD
Sep 2016 – Dec 2017
The George S. Eisenbarth nPOD Award for Team Science
Role: Principal Investigator
Funding: UNIV OF MIAMI via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Nov 2015 – Sep 2016
Beta Cell Regeneration For Type 1 Diabetes
Role: Principal Investigator
Funding: UNIV OF MIAMI via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Sep 2014 – Aug 2018
Defining Islet Heterogeneity Using Single Islet Transcriptomics
Role: Principal Investigator
Funding: UNIV OF TENNESSEE KNOXVILLE via NATL INST OF HLTH NIDDK
Sep 2013 – Aug 2017
Pancreatic Volume in Preclinical Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2013 – Mar 2018
NPOD Coordinating Center
Role: Project Manager
Funding: JDRF
Sep 2012 – Aug 2016
The JDRF nPOD Viral Work Group: nPOD V
Role: Project Manager
Funding: JDRF

Education

Postdoctoral associate
1988-1990 · University of Florida, College of Medicine, Department of Medicine, Gastroenterology and Hepatology Division
Ph.D. Physiological Sciences, College of Veterinary Medicine
1988 · University of Florida
D.V.M., Honors, College of Veterinary Medicine
1980 · University of Florida
B.S., High Honors, Chemistry
1976 · University of Florida

Teaching Profile

Courses Taught
2018
GMS7980 Research for Doctoral Dissertation

Contact Details

Phones:
Business:
(352) 273-6129
Emails:
Business:
mct@ufl.edu
Administrative Support Ast I: