Seung-Chul Choi

Seung-Chul Choi,

Research Assistant Scientist

Department: MD-PATHOLOGY-GENERAL
Business Phone: (352) 392-2676
Business Email: seungchulchoi@ufl.edu

Publications

2021
Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondria metabolism
JCI Insight. 6(14) [DOI] 10.1172/jci.insight.143540.
2020
Efficacy of the Combination of Metformin and CTLA4Ig in the (NZB × NZW)F1 Mouse Model of Lupus Nephritis
ImmunoHorizons. 4(6):319-331 [DOI] 10.4049/immunohorizons.2000033.
2020
Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice.
Science translational medicine. 12(551) [DOI] 10.1126/scitranslmed.aax2220. [PMID] 32641487.
2020
Immune metabolism regulation of the germinal center response.
Experimental & molecular medicine. 52(3):348-355 [DOI] 10.1038/s12276-020-0392-2. [PMID] 32132626.
2020
Metabolic determinants of lupus pathogenesis.
Immunological reviews. 295(1):167-186 [DOI] 10.1111/imr.12847. [PMID] 32162304.
2020
T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice
JCI Insight. 5(11) [DOI] 10.1172/jci.insight.138274. [PMID] 32493841.
2019
Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters.
Frontiers in immunology. 10 [DOI] 10.3389/fimmu.2019.00833. [PMID] 31057554.
2018
Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-06686-0. [PMID] 30348969.
2018
Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01973. [PMID] 30233578.
2018
Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4+ T Cell Polarization.
Journal of immunology (Baltimore, Md. : 1950). 200(9):3087-3099 [DOI] 10.4049/jimmunol.1701179. [PMID] 29563177.
2017
The PBX1 lupus susceptibility gene regulates CD44 expression.
Molecular immunology. 85:148-154 [DOI] 10.1016/j.molimm.2017.02.016. [PMID] 28257976.
2016
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Journal of immunology (Baltimore, Md. : 1950). 196(1):80-90 [DOI] 10.4049/jimmunol.1501537. [PMID] 26608911.
2016
Immune Cell Metabolism in Systemic Lupus Erythematosus
Current Rheumatology Reports. 18(11) [DOI] 10.1007/s11926-016-0615-7.
2016
Metabolic Factors that Contribute to Lupus Pathogenesis.
Critical reviews in immunology. 36(1):75-98 [DOI] 10.1615/CritRevImmunol.2016017164. [PMID] 27480903.
2016
The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950). 197(2):458-69 [DOI] 10.4049/jimmunol.1502283. [PMID] 27296664.
2015
Genetic and cellular dissection of the activation of AM14 rheumatoid factor B cells in a mouse model of lupus.
Journal of leukocyte biology. 98(2):209-21 [DOI] 10.1189/jlb.1A1214-576R. [PMID] 25957308.
2015
Normalization of CD4+ T cell metabolism reverses lupus.
Science translational medicine. 7(274) [DOI] 10.1126/scitranslmed.aaa0835. [PMID] 25673763.
2014
The Combination of Metformin and 2-Deoxy-D-Glucose Normalizes Cd4 T Cell Metabolism and Functions, and Reverse Disease in Murine Models of Lupus.
Arthritis & Rheumatology. 66(10, SI)

Grants

Jul 2020 ACTIVE
Determinants of follicular helper T cell expansion in lupus
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2019 ACTIVE
Gut dysbiosis and tryptophan metabolism in lupus
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2018 ACTIVE
Characterization of SLE-susceptibility loci on mouse chromosome 1
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID

Contact Details

Phones:
Business:
(352) 392-2676
Emails: