William L Clapp

William L Clapp, M.D.


Department: MD-PATHOLOGY
Business Phone: (352) 265-9900
Business Email: bevemara@ufl.edu

About William L Clapp

Dr. William L. Clapp serves as Professor and Director of Renal Pathology in the Department of Pathology, Immunology and Laboratory Medicine. The Renal Pathology service is one of the busiest in the southeastern U.S. and evaluates native and transplant renal biopsies, from UF Health and from numerous other institutions in Florida, including in Orlando, Tampa and Miami.

Dr. Clapp’s teaching interests and responsibilities include the Directorship of the Kidney and Urinary Tract (KUT) course for University of Florida College of Medicine students. He has taught renal pathology in the UF COM for numerous years. For several years, he also taught the cell and molecular biology of cancer.


Basic Science Teacher of the Year
2015 · University of Florida College of Medicine
Exemplary Teacher Award
2004 · University of Florida College of Medicine
Basic Science Teacher of the Year
2002 · University of Florida College of Medicine
Teaching Excellence Awards
1995-2020 · UF COM student classes
Individual National Research Service Award, NIH
1984-1987 · National Institutes of Health
Alpha Omega Alpha Honor Medical Society
1976 · University of Tennessee College of Medicine

Board Certifications

  • Hematology
    American Board of Pathology
  • Pathology – Anatomic and Clinical
    American Board of Pathology

Research Profile

Research interests include diagnostic aspects and also underlying mechanisms of kidney diseases, especially autoimmune diseases, and also renal development and renal structural-functional correlates.


Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus.
Arthritis & rheumatology (Hoboken, N.J.). 73(8):1467-1477 [DOI] 10.1002/art.41677. [PMID] 33559374.
Collapsing glomerulopathy in a patient with mixed connective tissue disease.
CEN case reports. 10(2):189-193 [DOI] 10.1007/s13730-020-00542-1. [PMID] 33052525.
Incidental Finding of a Large Right Atrial Thrombus in a Patient With Cerebral Lymphoma.
Journal of investigative medicine high impact case reports. 9 [DOI] 10.1177/23247096211001636. [PMID] 33749363.
Microscopic Polyangiitis With Diffuse Alveolar Hemorrhage and Glomerulonephritis Complicating Acute Influenza Infection.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. [DOI] 10.1097/RHU.0000000000001730. [PMID] 33843777.
Mixed acinar-neuroendocrine carcinoma with amphicrine features of the pancreas: Two rare cases with diffuse co-expression of acinar and neuroendocrine markers.
Pathology international. 71(7):485-487 [DOI] 10.1111/pin.13105. [PMID] 34000758.
Infection-related Glomerulonephritis and C3 Glomerulonephritis – Similar Yet Dissimilar: A Case Report and Brief Review of Current Literature.
Cureus. 12(2) [DOI] 10.7759/cureus.7127. [PMID] 32140372.
Inhibition of IRF5 hyperactivation protects from lupus onset and severity.
The Journal of clinical investigation. 130(12):6700-6717 [DOI] 10.1172/JCI120288. [PMID] 32897883.
Liver Pathology in Mitochondrial Complex I Deficiency from Bi-Allelic Mutations in NDUFS2: A Report of Findings at Autopsy.
Fetal and pediatric pathology. 39(3):259-262 [DOI] 10.1080/15513815.2019.1651800. [PMID] 31411514.
Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?
Trends in molecular medicine. 25(7):626-639 [DOI] 10.1016/j.molmed.2019.04.002. [PMID] 31109797.
Pauci-immune proliferative glomerulonephritis and fungal endocarditis: More than a mere coincidence?
BMJ case reports. 12(3) [DOI] 10.1136/bcr-2018-229059. [PMID] 30846459.
Podocyte-specific expression of Cre recombinase promotes glomerular basement membrane thickening.
American journal of physiology. Renal physiology. 316(5):F1026-F1040 [DOI] 10.1152/ajprenal.00359.2018. [PMID] 30810063.
Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice.
Journal of inflammation (London, England). 16 [DOI] 10.1186/s12950-019-0215-1. [PMID] 31160886.
IgA nephropathy in African Americans: uncommon but possible.
JRSM open. 9(6) [DOI] 10.1177/2054270418783902. [PMID] 29942535.
Not all kidney disease in patients with diabetes is diabetic nephropathy.
Internal and emergency medicine. 13(7):1131-1132 [DOI] 10.1007/s11739-018-1895-x. [PMID] 29922901.
Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-31779-7. [PMID] 30194334.
The skin-kidney connection: bullous pemphigoid associated with acute allograft rejection and membranous nephropathy.
Clinical case reports. 6(2):432-433 [DOI] 10.1002/ccr3.1324. [PMID] 29445491.
Expression of sodium-dependent dicarboxylate transporter 1 (NaDC1/SLC13A2) in normal and neoplastic human kidney.
American journal of physiology. Renal physiology. 312(3):F427-F435 [DOI] 10.1152/ajprenal.00559.2016. [PMID] 27927654.
Trifecta of light chain cast nephropathy, monoclonal plasma cell infiltrates, and light chain proximal tubulopathy.
Kidney international. 92(6) [DOI] 10.1016/j.kint.2017.08.010. [PMID] 29153147.
Use of C4d as a diagnostic tool to classify membranoproliferative glomerulonephritis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia. 37(1):78-86 [DOI] 10.1016/j.nefro.2016.05.011. [PMID] 27595516.
Pathogenesis of proteinuria in idiopathic minimal change disease: molecular mechanisms.
Pediatric nephrology (Berlin, Germany). 31(12):2179-2189 [PMID] 27384691.
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Osteogenic changes in kidneys of hyperoxaluric rats.
Biochimica et biophysica acta. 1852(9):2000-12 [DOI] 10.1016/j.bbadis.2015.06.020. [PMID] 26122267.
Repurposed biological scaffolds: kidney to pancreas.
Organogenesis. 11(2):47-57 [DOI] 10.1080/15476278.2015.1067354. [PMID] 26252820.
Bioengineered Pancreas: Human Insulin-Secreting Islet Cells in Vascularized Pig Kidney Scaffolds
Nephrology Dialysis Transplantation. 29(3)
Isolation of Tacaribe virus, a Caribbean arenavirus, from host-seeking Amblyomma americanum ticks in Florida.
PloS one. 9(12) [DOI] 10.1371/journal.pone.0115769. [PMID] 25536075.
Expression of the ammonia transporter family member, Rh B Glycoprotein, in the human kidney.
American journal of physiology. Renal physiology. 304(7):F972-81 [DOI] 10.1152/ajprenal.00550.2012. [PMID] 23324176.
Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer.
International journal of nanomedicine. 8:4481-94 [DOI] 10.2147/IJN.S41782. [PMID] 24293999.
Mouse stem cells seeded into decellularized rat kidney scaffolds endothelialize and remodel basement membranes.
Organogenesis. 8(2):49-55 [DOI] 10.4161/org.20209. [PMID] 22692231.
A new form of myeloma “kidney”: shortened hemofilter survival and implications for membrane filtration plasmapheresis.
Clinical nephrology. 75(2):120-4 [PMID] 21255541.
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Primary renal carcinoid tumors: clinicopathologic features of 9 cases with emphasis on novel immunohistochemical findings.
Human pathology. 42(10):1554-61 [DOI] 10.1016/j.humpath.2010.12.019. [PMID] 21496872.
B-cell lymphoma with Mott cell differentiation in two young adult dogs.
Veterinary clinical pathology. 38(1):113-20 [DOI] 10.1111/j.1939-165X.2008.00101.x. [PMID] 19171017.
Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds.
Journal of the American Society of Nephrology : JASN. 20(11):2338-47 [DOI] 10.1681/ASN.2008111196. [PMID] 19729441.
Hematology of healthy Florida manatees (Trichechus manatus).
Veterinary clinical pathology. 38(2):183-93 [DOI] 10.1111/j.1939-165X.2009.00113.x. [PMID] 19490571.
Sebastian syndrome with abnormal platelet response to ristocetin.
Laboratory hematology : official publication of the International Society for Laboratory Hematology. 14(3):19-23 [DOI] 10.1532/LH96.08007. [PMID] 18812282.
Shortened hemofilter survival time due to lipid infusion in continuous renal replacement therapy.
Nephron. Clinical practice. 108(1):c5-9 [PMID] 18059111.
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A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole.
Antimicrobial agents and chemotherapy. 51(5):1855-8 [PMID] 17325226.
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Acute-onset hearing loss with renal failure: differential diagnosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 47(3):553-8 [PMID] 16490636.
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Expression of the ammonia transporter, rh C glycoprotein, in normal and neoplastic human kidney.
Journal of the American Society of Nephrology : JASN. 17(10):2670-9 [PMID] 16928804.
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Tissue adhesion to bioactive glass-coated silicone tubing in a rat model of peritoneal dialysis catheters and catheter tunnels.
Kidney international. 63(2):702-8 [PMID] 12631137.
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Malignant mesothelioma of tunica vaginalis testis: a fatal case with liver metastasis.
The Journal of urology. 167(2 Pt 1):645-6 [PMID] 11792939.
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Outcome of kidney transplants in patients known to be flow cytometry crossmatch positive.
Transplantation. 71(8):1098-102 [PMID] 11374409.
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Proteinuria: potential causes and approach to evaluation.
The American journal of the medical sciences. 320(3):188-94 [PMID] 11014373.
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Macrophages and chronic renal allograft nephropathy.
Kidney international. Supplement. 57:S42-9 [PMID] 8941921.
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Thromboxane synthase expression in renal transplant patients with rejection.
Transplantation. 59(4):490-4 [PMID] 7878751.
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Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney.
Kidney international. 46(3):653-65 [PMID] 7527874.
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Segmental localization of mRNAs encoding Na(+)-K(+)-ATPase alpha- and beta-subunit isoforms in rat kidney using RT-PCR.
Kidney international. 46(3):627-38 [PMID] 7996786.
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Regulation of kidney organogenesis: homeobox genes, growth factors, and Wilms tumor.
Current opinion in nephrology and hypertension. 2(3):419-29 [PMID] 7922202.
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Morphologic heterogeneity along the rat inner medullary collecting duct.
Laboratory investigation; a journal of technical methods and pathology. 60(2):219-30 [PMID] 2915516.
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Axial heterogeneity in the handling of albumin by the rabbit proximal tubule.
Laboratory investigation; a journal of technical methods and pathology. 58(5):549-58 [PMID] 3367637.
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Structure and function of the inner medullary collecting duct.
Kidney international. 34(4):441-54 [PMID] 3059025.
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Ultrastructural localization of acidic compartments in cells of isolated rabbit PCT.
The American journal of physiology. 253(1 Pt 2):F95-103 [PMID] 2440316.
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Fellowship – Hematology
1981 · National Naval Medical Center
Residency – Pathology – Anatomic and Clinical
1980 · National Naval Medical Center
Internship – Pathology – Anatomic and Clinical
1977 · National Naval Medical Center
Medical Degree
1976 · University of Tenneessee

Teaching Profile

Courses Taught
BMS6638C Kidney & Urinary Tract
DEN6350 General Pathology

Contact Details

(352) 265-9900