Timothy J Garrett

Timothy J Garrett,

Associate Professor

Department: MD-PATHOLOGY-GENERAL
Business Phone: (352) 273-5050
Business Email: tgarrett@ufl.edu

About Timothy J Garrett

Dr. Garrett received his undergraduate degree from the University of Georgia in Chemistry graduating Summa Cum Laude with Highest Honors (1999). As an undergraduate, he worked in the lab of Dr. I. Jonathan Amster on the characterization of bacterial proteins using MALDI-TOF completing an undergraduate honors thesis entitled “Improved methods for on-probe cleanup of unpurified protein samples for MALDI time-of-flight mass spectrometry”. He was the recipient of a Howard Hughes Medical Institute fellowship for undergraduate research. After a 2 years hiatus working in software consulting and thin-film development, he enrolled in the Ph.D. program at the University of Florida working under the direction of Dr. Richard A. Yost. As a graduate student, he developed the first imaging mass spectrometry-based on ion trap instrumentation through a partnership with Thermo and studied the disposition of phospholipids in brain tissue. His work involved the characterization of phospholipids using tandem mass spectrometry and described the need for tandem mass spectrometry to both separate and identify this complex lipid species directly from tissue. As a graduate student, he received a Grinter Fellowship (2001-2002), a Proctor & Gamble Award for excellence in graduate research (2005), the Baites-Laitinen award (2006), and the Crow-Stasch award for excellence in publication (2007 and 2008). Finally, his publication entitled “Imaging mass spectrometry with a new intermediate-pressure MALDI linear ion trap mass spectrometer” received the best-applied graduate student paper for the Internal Journal of Mass Spectrometry (Int.. J. Mass Spectrom., 2007, 260, 2-3, 166-176). After graduating in 2006, he accepted a Research Assistant Professorship at the University of Florida in the Department of Medicine where he began research on targeted quantitation for clinical research and diagnostics using mass spectrometry. In 2014, he transitioned to an Assistant Professor in the Department of Pathology, Immunology, and Laboratory Medicine at the University of Florida continuing his work to translate mass spectrometry to clinical areas. As a clinical member of Pathology, he worked on the development of several new clinical assays utilizing mass spectrometry that are currently used in clinical toxicology. He is currently an Associate Professor in the Department of Pathology, where he is also the Director of high throughput metabolomics, for the Southeast Center for Integrated Metabolomics and conducts research in the application of metabolomics to disease diagnosis and clinical diagnostics. Prof Garrett is the author of over 60 publications and is an Editorial Board member for Clinical Mass Spectrometry and PLOSOne. His current interest is in the application of direct tissue analysis approaches such as MALDI, DESI, and LMJSSP as well as the use of high-resolution mass spectrometry in metabolomics and routine diagnostics. He enjoys the interplay between technological advancement and clinical analysis providing unique opportunities and experiences to develop the future of clinical diagnostics.

Research Profile

Areas of Interest
  • Lipidomics
  • Mass Spectrometry
  • Metabolomics

Publications

2021
A Novel Technique for Redox Lipidomics Using Mass Spectrometry: Application on Vegetable Oils Used to Fry Potatoes.
Journal of the American Society for Mass Spectrometry. 32(7):1798-1809 [DOI] 10.1021/jasms.1c00150. [PMID] 34096708.
2021
A Review of Efforts to Improve Lipid Stability during Sample Preparation and Standardization Efforts to Ensure Accuracy in the Reporting of Lipid Measurements.
Lipids. 56(1):3-16 [DOI] 10.1002/lipd.12263. [PMID] 32519378.
2021
Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-80982-6. [PMID] 33479274.
2021
Cellular Metabolomics Profiles Associated With Drug Chemosensitivity in AML.
Frontiers in oncology. 11 [DOI] 10.3389/fonc.2021.678008. [PMID] 34178663.
2021
Exploring Associations Between Metabolites and Symptoms of Fatigue, Depression and Pain in Women With Fibromyalgia.
Biological research for nursing. 23(1):119-126 [DOI] 10.1177/1099800420941109. [PMID] 32677448.
2021
Extracellular Vesicle Analysis by Paper Spray Ionization Mass Spectrometry.
Metabolites. 11(5) [DOI] 10.3390/metabo11050308. [PMID] 34065030.
2021
Germline SUCLG2 Variants in Patients with Pheochromocytoma and Paraganglioma.
Journal of the National Cancer Institute. [DOI] 10.1093/jnci/djab158. [PMID] 34415331.
2021
Intraspecific variation in polar and nonpolar metabolite profiles of a threatened Caribbean coral.
Metabolomics : Official journal of the Metabolomic Society. 17(7) [DOI] 10.1007/s11306-021-01808-0. [PMID] 34143280.
2021
Lactate Dehydrogenase B and Pyruvate Oxidation Pathway Associated With Carfilzomib-Related Cardiotoxicity in Multiple Myeloma Patients: Result of a Multi-Omics Integrative Analysis.
Frontiers in cardiovascular medicine. 8 [DOI] 10.3389/fcvm.2021.645122. [PMID] 33996940.
2021
Metabolic Changes Are Associated with Melphalan Resistance in Multiple Myeloma.
Journal of proteome research. 20(6):3134-3149 [DOI] 10.1021/acs.jproteome.1c00022. [PMID] 34014671.
2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications. 12(1) [DOI] 10.1038/s41467-021-24755-9. [PMID] 34294718.
2021
Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice.
Oncotarget. 12(18):1737-1748 [DOI] 10.18632/oncotarget.28057. [PMID] 34504647.
2021
Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance.
Cancer discovery. 11(8):2072-2093 [DOI] 10.1158/2159-8290.CD-20-1453. [PMID] 33757970.
2021
Rapid Diagnosis of Prostate Cancer Disease Progression Using Paper Spray Ionization Mass Spectrometry.
Analytical chemistry. 93(22):7774-7780 [DOI] 10.1021/acs.analchem.1c00943. [PMID] 34043339.
2020
Analysis of Tryptophan Metabolites in Serum Using Wide-Isolation Strategies for UHPLC-HRMS/MS.
Analytical chemistry. 92(3):2550-2557 [DOI] 10.1021/acs.analchem.9b04210. [PMID] 31927994.
2020
Antibiotics Effects on the Fecal Metabolome in Preterm Infants.
Metabolites. 10(8) [DOI] 10.3390/metabo10080331. [PMID] 32823682.
2020
Author Correction: Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-65513-z. [PMID] 32433574.
2020
Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes.
Blood. 136(7):857-870 [DOI] 10.1182/blood.2019003257. [PMID] 32403132.
2020
Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S.
Diabetes care. 43(6):1360-1362 [DOI] 10.2337/dc19-1941. [PMID] 32273273.
2020
Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus.
Scientific reports. 10(1) [DOI] 10.1038/s41598-019-56823-y. [PMID] 31932597.
2020
Detection of Chemical Weapon Nerve Agents in Bone by Liquid Chromatography-Mass Spectrometry.
Journal of analytical toxicology. 44(4):391-401 [DOI] 10.1093/jat/bkz118. [PMID] 32103269.
2020
Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world.
Metabolomics : Official journal of the Metabolomic Society. 16(5) [DOI] 10.1007/s11306-020-01665-3. [PMID] 32307636.
2020
Exposure to recurrent hypoglycemia alters hippocampal metabolism in treated streptozotocin-induced diabetic rats.
CNS neuroscience & therapeutics. 26(1):126-135 [DOI] 10.1111/cns.13186. [PMID] 31282100.
2020
Global Metabolomics in Allogeneic Hematopoietic Cell Transplantation Recipients Discordant for Chronic Graft-versus-Host Disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 26(10):1803-1810 [DOI] 10.1016/j.bbmt.2020.06.014. [PMID] 32592859.
2020
Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice.
Science translational medicine. 12(551) [DOI] 10.1126/scitranslmed.aax2220. [PMID] 32641487.
2020
Identification and quantification of honeybee venom constituents by multiplatform metabolomics.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-78740-1. [PMID] 33303913.
2020
Integrated RNA and metabolite profiling of urine liquid biopsies for prostate cancer biomarker discovery.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-60616-z. [PMID] 32111915.
2020
Intensive Care Unit Delirium in Surgical Patients Is Associated with Upregulation in Tryptophan Metabolism.
Pharmacotherapy. 40(6):500-506 [DOI] 10.1002/phar.2392. [PMID] 32246498.
2020
Lipid Annotator: Towards Accurate Annotation in Non-Targeted Liquid Chromatography High-Resolution Tandem Mass Spectrometry (LC-HRMS/MS) Lipidomics Using A Rapid and User-Friendly Software.
Metabolites. 10(3) [DOI] 10.3390/metabo10030101. [PMID] 32178227.
2020
Mass Spectrometry Techniques in Emerging Pathogens Studies: COVID-19 Perspectives.
Journal of the American Society for Mass Spectrometry. 31(10):2013-2024 [DOI] 10.1021/jasms.0c00238. [PMID] 32880453.
2020
Metabolomic Alteration in the Mouse Distal Colonic Mucosa after Oral Gavage with Oxalobacter formigenes.
Metabolites. 10(10) [DOI] 10.3390/metabo10100405. [PMID] 33065971.
2020
Metabolomic Differentials in Women With and Without Fibromyalgia.
Clinical and translational science. 13(1):67-77 [DOI] 10.1111/cts.12679. [PMID] 31411365.
2020
Metabolomics of primary cutaneous melanoma and matched adjacent extratumoral microenvironment.
PloS one. 15(10) [DOI] 10.1371/journal.pone.0240849. [PMID] 33108391.
2020
Method Optimization: Analysis of Benzbromarone and Tolfenamic Acid in Citrus Tissues and Soil Using Liquid Chromatography Coupled With Triple-Quadrupole Mass Spectrometry.
Frontiers in plant science. 11 [DOI] 10.3389/fpls.2020.00222. [PMID] 32210995.
2020
Modifications of the urinary metabolome in young women after cranberry juice consumption were revealed using the UHPLC-Q-orbitrap-HRMS-based metabolomics approach.
Food & function. 11(3):2466-2476 [DOI] 10.1039/c9fo02266j. [PMID] 32133462.
2020
Oxalobacter formigenes produces metabolites and lipids undetectable in oxalotrophic Bifidobacterium animalis.
Metabolomics : Official journal of the Metabolomic Society. 16(12) [DOI] 10.1007/s11306-020-01747-2. [PMID] 33219444.
2020
Rapid Prostate Cancer Noninvasive Biomarker Screening Using Segmented Flow Mass Spectrometry-Based Untargeted Metabolomics.
Journal of proteome research. 19(5):2080-2091 [DOI] 10.1021/acs.jproteome.0c00006. [PMID] 32216312.
2020
Relationships between Very Low-Density Lipoproteins-Ceramides, -Diacylglycerols, and -Triacylglycerols in Insulin-Resistant Men.
Lipids. 55(4):387-393 [DOI] 10.1002/lipd.12244. [PMID] 32415687.
2020
Targeting pheochromocytoma/paraganglioma with polyamine inhibitors.
Metabolism: clinical and experimental. 110 [DOI] 10.1016/j.metabol.2020.154297. [PMID] 32562798.
2020
Toward Comprehensive Per- and Polyfluoroalkyl Substances Annotation Using FluoroMatch Software and Intelligent High-Resolution Tandem Mass Spectrometry Acquisition.
Analytical chemistry. 92(16):11186-11194 [DOI] 10.1021/acs.analchem.0c01591. [PMID] 32806901.
2020
Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry Metabolomics and Lipidomics Study of Stool from Transgenic Parkinson’s Disease Mice Following Immunotherapy.
Journal of proteome research. 19(1):424-431 [DOI] 10.1021/acs.jproteome.9b00605. [PMID] 31713431.
2019
Chronic maternal cortisol excess during late gestation leads to metabolic alterations in the newborn heart.
American journal of physiology. Endocrinology and metabolism. 316(3):E546-E556 [DOI] 10.1152/ajpendo.00386.2018. [PMID] 30620638.
2019
Decoding the Metabolome and Lipidome of Child Malnutrition by Mass Spectrometric Techniques: Present Status and Future Perspectives.
Analytical chemistry. 91(23):14784-14791 [DOI] 10.1021/acs.analchem.9b03338. [PMID] 31682425.
2019
Editorial and Review: 33rd Asilomar Conference on Mass Spectrometry-Impact of Metabolomics in Translational and Clinical Research.
Journal of the American Society for Mass Spectrometry. 30(2):199-202 [DOI] 10.1007/s13361-018-2113-9. [PMID] 30552567.
2019
Effective Liquid Chromatography-Trapped Ion Mobility Spectrometry-Mass Spectrometry Separation of Isomeric Lipid Species.
Analytical chemistry. 91(8):5021-5027 [DOI] 10.1021/acs.analchem.8b04979. [PMID] 30896930.
2019
Impact of exenatide on mitochondrial lipid metabolism in mice with nonalcoholic steatohepatitis.
The Journal of endocrinology. 241(3):293-305 [DOI] 10.1530/JOE-19-0007. [PMID] 31082799.
2019
Impact of matrix effects and ionization efficiency in non-quantitative untargeted metabolomics.
Metabolomics : Official journal of the Metabolomic Society. 15(10) [DOI] 10.1007/s11306-019-1597-z. [PMID] 31584114.
2019
Lipidomics for wildlife disease etiology and biomarker discovery: a case study of pansteatitis outbreak in South Africa.
Metabolomics : Official journal of the Metabolomic Society. 15(3) [DOI] 10.1007/s11306-019-1490-9. [PMID] 30838461.
2019
Metabolic Profile of Supragingival Plaque Exposed to Arginine and Fluoride.
Journal of dental research. 98(11):1245-1252 [DOI] 10.1177/0022034519869906. [PMID] 31454264.
2019
Metabolomic and lipidomic characterization of Oxalobacter formigenes strains HC1 and OxWR by UHPLC-HRMS.
Analytical and bioanalytical chemistry. 411(19):4807-4818 [DOI] 10.1007/s00216-019-01639-y. [PMID] 30740635.
2019
Metabolomic profiles differ among unique genotypes of a threatened Caribbean coral.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-42434-0. [PMID] 30988456.
2019
Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri.
PloS one. 14(9) [DOI] 10.1371/journal.pone.0222393. [PMID] 31545840.
2019
Proteometabolomics of Melphalan Resistance in Multiple Myeloma.
Methods in molecular biology (Clifton, N.J.). 1996:273-296 [DOI] 10.1007/978-1-4939-9488-5_21. [PMID] 31127562.
2019
Rapid Quantitation of 25-Hydroxyvitamin D2 and D3 in Human Serum Using Liquid Chromatography/Drift Tube Ion Mobility-Mass Spectrometry.
Analytical chemistry. 91(21):13555-13561 [DOI] 10.1021/acs.analchem.9b02683. [PMID] 31592654.
2019
Re-modeling of foliar membrane lipids in a seagrass allows for growth in phosphorus-deplete conditions.
PloS one. 14(11) [DOI] 10.1371/journal.pone.0218690. [PMID] 31774814.
2019
Software tool for internal standard based normalization of lipids, and effect of data-processing strategies on resulting values.
BMC bioinformatics. 20(1) [DOI] 10.1186/s12859-019-2803-8. [PMID] 31035918.
2019
Strain-Level Differentiation of Bacteria by Paper Spray Ionization Mass Spectrometry.
Analytical chemistry. 91(8):4964-4968 [DOI] 10.1021/acs.analchem.9b00330. [PMID] 30888152.
2019
Untargeted metabolomic analysis in non-fasted diabetic dogs by UHPLC-HRMS.
Metabolomics : Official journal of the Metabolomic Society. 15(2) [DOI] 10.1007/s11306-019-1477-6. [PMID] 30830416.
2018
A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women.
Aging. 10(10):2624-2635 [DOI] 10.18632/aging.101574. [PMID] 30318485.
2018
Corrigendum: Divisions of labor in the thiamin biosynthetic pathway among organs of maize.
Frontiers in plant science. 9 [DOI] 10.3389/fpls.2018.00148. [PMID] 29491877.
2018
Distinct Metabolic features differentiating FLT3-ITD AML from FLT3-WT childhood Acute Myeloid Leukemia.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-23863-9. [PMID] 29615816.
2018
Examining heat treatment for stabilization of the lipidome.
Bioanalysis. 10(5):291-305 [DOI] 10.4155/bio-2017-0209. [PMID] 29451398.
2018
Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma.
The EMBO journal. 37(23) [DOI] 10.15252/embj.201798772. [PMID] 30322894.
2018
l-Carnitine Inhibits Lipopolysaccharide-Induced Nitric Oxide Production of SIM-A9 Microglia Cells.
ACS chemical neuroscience. 9(5):901-905 [DOI] 10.1021/acschemneuro.7b00468. [PMID] 29370524.
2018
Mass Spectrometric Methodologies for Investigating the Metabolic Signatures of Parkinson’s Disease: Current Progress and Future Perspectives.
Analytical chemistry. 90(5):2979-2986 [DOI] 10.1021/acs.analchem.7b04084. [PMID] 29384654.
2018
Metabolomic association between venous thromboembolism in critically ill trauma patients and kynurenine pathway of tryptophan metabolism.
Thrombosis research. 165:6-13 [DOI] 10.1016/j.thromres.2018.03.003. [PMID] 29544199.
2018
Metabolomic profiles associated with bone mineral density in US Caucasian women.
Nutrition & metabolism. 15 [DOI] 10.1186/s12986-018-0296-5. [PMID] 30116286.
2018
Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain.
Frontiers in neuroscience. 12 [DOI] 10.3389/fnins.2018.00032. [PMID] 29440987.
2018
MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism.
Cell reports. 24(6):1585-1596 [DOI] 10.1016/j.celrep.2018.07.013. [PMID] 30089268.
2018
Multiomics approach reveals metabolic changes in the heart at birth.
American journal of physiology. Endocrinology and metabolism. 315(6):E1212-E1223 [DOI] 10.1152/ajpendo.00297.2018. [PMID] 30300011.
2018
Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults With Knee Pain
Clinical Journal of Pain. 34(2):182-189 [DOI] 10.1097/AJP.0000000000000517. [PMID] 28542024.
2018
Optimization of Folch, Bligh-Dyer, and Matyash sample-to-extraction solvent ratios for human plasma-based lipidomics studies.
Analytica chimica acta. 1037:351-357 [DOI] 10.1016/j.aca.2018.08.004. [PMID] 30292311.
2018
Pilot Study of Metabolomics and Psychoneurological Symptoms in Women With Early Stage Breast Cancer.
Biological research for nursing. 20(2):227-236 [DOI] 10.1177/1099800417747411. [PMID] 29258398.
2018
Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis.
American journal of physiology. Endocrinology and metabolism. 315(2):E163-E173 [DOI] 10.1152/ajpendo.00023.2018. [PMID] 29634314.
2017
A Robust Lipidomics Workflow for Mammalian Cells, Plasma, and Tissue Using Liquid-Chromatography High-Resolution Tandem Mass Spectrometry.
Methods in molecular biology (Clifton, N.J.). 1609:91-106 [DOI] 10.1007/978-1-4939-6996-8_10. [PMID] 28660577.
2017
Comparison of global metabolite extraction strategies for soybeans using UHPLC-HRMS.
Analytical and bioanalytical chemistry. 409(26):6173-6180 [DOI] 10.1007/s00216-017-0557-6. [PMID] 28844081.
2017
Expanding Lipidome Coverage Using LC-MS/MS Data-Dependent Acquisition with Automated Exclusion List Generation.
Journal of the American Society for Mass Spectrometry. 28(5):908-917 [DOI] 10.1007/s13361-017-1608-0. [PMID] 28265968.
2017
Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.
Journal of lipid research. 58(12):2275-2288 [DOI] 10.1194/jlr.M079012. [PMID] 28986437.
2017
High Prevalence of Low Serum Biologically Active Testosterone in Older Male Veterans.
Journal of the American Medical Directors Association. 18(4):366.e17-366.e24 [DOI] 10.1016/j.jamda.2016.12.077. [PMID] 28214238.
2017
Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.00655. [PMID] 28659913.
2017
LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry data.
BMC bioinformatics. 18(1) [DOI] 10.1186/s12859-017-1744-3. [PMID] 28693421.
2017
LipidPioneer : A Comprehensive User-Generated Exact Mass Template for Lipidomics.
Journal of the American Society for Mass Spectrometry. 28(3):562-565 [DOI] 10.1007/s13361-016-1579-6. [PMID] 28074328.
2017
LipidQC: Method Validation Tool for Visual Comparison to SRM 1950 Using NIST Interlaboratory Comparison Exercise Lipid Consensus Mean Estimate Values.
Analytical chemistry. 89(24):13069-13073 [DOI] 10.1021/acs.analchem.7b04042. [PMID] 29148710.
2017
Metabolomic Evaluation of the Consequences of Plasma Cystathionine Elevation in Adults with Stable Angina Pectoris.
The Journal of nutrition. 147(9):1658-1668 [DOI] 10.3945/jn.117.254029. [PMID] 28794210.
2017
Monitoring Dopamine ex Vivo during Electrical Stimulation Using Liquid-Microjunction Surface Sampling.
Analytical chemistry. 89(24):13658-13665 [DOI] 10.1021/acs.analchem.7b04463. [PMID] 29088914.
2017
Precast Gelatin-Based Molds for Tissue Embedding Compatible with Mass Spectrometry Imaging.
Analytical chemistry. 89(1):576-580 [DOI] 10.1021/acs.analchem.6b04185. [PMID] 27935272.
2017
Study of early stage non-small-cell lung cancer using Orbitrap-based global serum metabolomics.
Journal of cancer research and clinical oncology. 143(4):649-659 [DOI] 10.1007/s00432-017-2347-0. [PMID] 28168355.
2017
Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long-term effects on neurological recovery.
Brain and behavior. 7(5) [DOI] 10.1002/brb3.688. [PMID] 28523230.
2017
UHPLC-Q-Orbitrap-HRMS-based global metabolomics reveal metabolome modifications in plasma of young women after cranberry juice consumption.
The Journal of nutritional biochemistry. 45:67-76 [DOI] 10.1016/j.jnutbio.2017.03.007. [PMID] 28433923.
2017
Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-09908-5. [PMID] 28842637.
2016
13C Metabolomics: NMR and IROA for Unknown Identification.
Current Metabolomics. 4(2):116-120 [DOI] 10.2174/2213235X04666160407212156. [PMID] 28090435.
2016
A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.
Hypertension (Dallas, Tex. : 1979). 68(3):621-9 [DOI] 10.1161/HYPERTENSIONAHA.116.07328. [PMID] 27381900.
2016
A Targeted Metabolomics Assay to Measure Eight Purines in the Diet of Common Bottlenose Dolphins, Tursiops truncatus.
Journal of chromatography & separation techniques. 7(5) [PMID] 27904786.
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2016
An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile Infection.
PloS one. 11(2) [DOI] 10.1371/journal.pone.0148824. [PMID] 26871580.
2016
Growth substrates and caleosin-mediated functions affect conidial virulence in the insect pathogenic fungus Beauveria bassiana.
Microbiology (Reading, England). 162(11):1913-1921 [DOI] 10.1099/mic.0.000375. [PMID] 27655425.
2016
Isotopic Ratio Outlier Analysis of the S. cerevisiae Metabolome Using Accurate Mass Gas Chromatography/Time-of-Flight Mass Spectrometry: A New Method for Discovery.
Analytical chemistry. 88(5):2747-54 [DOI] 10.1021/acs.analchem.5b04263. [PMID] 26820234.
2016
Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.
American journal of physiology. Endocrinology and metabolism. 310(7):E484-94 [DOI] 10.1152/ajpendo.00492.2015. [PMID] 26814015.
2016
Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol.
Metabolomics : Official journal of the Metabolomic Society. 12(10) [DOI] 10.1007/s11306-016-1098-2. [PMID] 28217401.
2016
Skeletal muscle fiber analysis by atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometric imaging at high mass and high spatial resolution.
Proteomics. 16(11-12):1822-4 [DOI] 10.1002/pmic.201500536. [PMID] 27198224.
2015
Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients.
Metabolic syndrome and related disorders. 13(5):195-202 [DOI] 10.1089/met.2014.0132. [PMID] 25664967.
2015
Comparison of blood plasma sample preparation methods for combined LC-MS lipidomics and metabolomics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1002:260-6 [DOI] 10.1016/j.jchromb.2015.08.018. [PMID] 26343017.
2015
Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease.
American journal of physiology. Endocrinology and metabolism. 309(4):E311-9 [DOI] 10.1152/ajpendo.00161.2015. [PMID] 26058864.
2015
Integrating Metabolomics and Genomics Reveals Novel Biomarkers of Hydrochlorothiazide Response in Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study.
Clinical Pharmacology & Therapeutics. 97(1)
2015
Involvement of a caleosin in lipid storage, spore dispersal, and virulence in the entomopathogenic filamentous fungus, Beauveria bassiana.
Environmental microbiology. 17(11):4600-14 [DOI] 10.1111/1462-2920.12990. [PMID] 26235819.
2015
Ionization sources and mass analyzers in MS imaging.
Bioanalysis. 7(20):2629-37 [DOI] 10.4155/bio.15.187. [PMID] 26511148.
2015
Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells using Jurkat T lymphocyte Cells.
Journal of proteomics & bioinformatics. 8(6):126-132 [PMID] 26401069.
View on: PubMed
2015
Metabolomic Analysis of Oxidative and Glycolytic Skeletal Muscles by Matrix-Assisted Laser Desorption/IonizationMass Spectrometric Imaging (MALDI MSI).
Journal of the American Society for Mass Spectrometry. 26(6):915-23 [DOI] 10.1007/s13361-015-1133-y. [PMID] 25893271.
2015
Profiling the metabolome changes caused by cranberry procyanidins in plasma of female rats using (1) H NMR and UHPLC-Q-Orbitrap-HRMS global metabolomics approaches.
Molecular nutrition & food research. 59(11):2107-18 [DOI] 10.1002/mnfr.201500236. [PMID] 26264887.
2015
Quantitation of 25-hydroxyvitamin D2 and D3 in serum and plasma by LCMS/MS.
Bioanalysis. 7(2):167-78 [DOI] 10.4155/bio.14.229. [PMID] 25587834.
2014
Divisions of labor in the thiamin biosynthetic pathway among organs of maize.
Frontiers in plant science. 5 [DOI] 10.3389/fpls.2014.00370. [PMID] 25136345.
2014
Salvage of the thiamin pyrimidine moiety by plant TenA proteins lacking an active-site cysteine.
The Biochemical journal. 463(1):145-55 [DOI] 10.1042/BJ20140522. [PMID] 25014715.
2014
Stable pediatric kidney transplant recipients run higher urine indoleamine 2, 3 dioxygenase (IDO) levels than healthy children.
Pediatric transplantation. 18(3):254-7 [DOI] 10.1111/petr.12232. [PMID] 24483723.
2014
Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells.
American journal of physiology. Endocrinology and metabolism. 307(1):E93-101 [DOI] 10.1152/ajpendo.00697.2013. [PMID] 24824655.
2013
Evaluating the Urine Matrix Effects in Lc-Ms/Ms Analysis Following Filtration for Pain Management Compounds
Therapeutic Drug Monitoring. 35:727-728
2013
Identification and characterization of the missing pyrimidine reductase in the plant riboflavin biosynthesis pathway.
Plant physiology. 161(1):48-56 [DOI] 10.1104/pp.112.208488. [PMID] 23150645.
2013
Indoleamine 2,3-dioxygenase activity and clinical outcome following induction chemotherapy and concurrent chemoradiation in Stage III non-small cell lung cancer.
Oncoimmunology. 2(3) [PMID] 23802083.
View on: PubMed
2013
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
The Journal of nutrition. 143(11):1719-27 [DOI] 10.3945/jn.113.180588. [PMID] 23966327.
2013
Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.
Transplantation. 96(6):567-72 [DOI] 10.1097/TP.0b013e31829c7cec. [PMID] 23823655.
2013
Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells.
American journal of physiology. Endocrinology and metabolism. 304(4):E342-51 [DOI] 10.1152/ajpendo.00359.2012. [PMID] 23211517.
2012
Automated MALDI matrix coating system for multiple tissue samples for imaging mass spectrometry.
Journal of the American Society for Mass Spectrometry. 23(3):563-9 [DOI] 10.1007/s13361-011-0324-4. [PMID] 22234508.
2012
Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.
Cell cycle (Georgetown, Tex.). 11(17):3250-9 [DOI] 10.4161/cc.21611. [PMID] 22894899.
2012
High-field asymmetric waveform ion mobility spectrometry with solvent vapor addition: a potential greener bioanalytical technique.
Bioanalysis. 4(11):1363-75 [DOI] 10.4155/bio.12.110. [PMID] 22720654.
2012
Immune Biomarker Panel Measuring Both Extremes of Immunosuppression Associate With Acute Rejection (Ar) Or Major Infection Events (Mie)
American Journal of Transplantation. 12
2012
Involvement of Free Cholesterol and High Density Lipoprotein in Development and Resistance of the Preimplantation Bovine Embryo To Heat Shock
Reproduction in Domestic Animals. 47:593-594
2012
Involvement of free cholesterol and high-density lipoprotein in development and resistance of the preimplantation bovine embryo to heat shock.
Journal of animal science. 90(11):3762-9 [DOI] 10.2527/jas.2011-4717. [PMID] 22665658.
2011
Characterization of protonated phospholipids as fragile ions in quadrupole ion trap mass spectrometry.
International journal of mass spectrometry. 308(2-3):299-306 [PMID] 22247650.
View on: PubMed
2011
Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging.
Rapid communications in mass spectrometry : RCM. 25(20):3178-84 [DOI] 10.1002/rcm.5189. [PMID] 21953974.
2011
Immune Biomarker Panel Monitoring Utilizing Ido Enzyme Activity and Cd4 Atp Levels: Prediction of Acute Rejection Vs. Viral Replication Events
Pediatric Transplantation. 15:321-328 [DOI] 10.1111/j.1399-3046.2011.01485.x. [PMID] 21492353.
2011
Immune biomarker panel monitoring utilizing IDO enzyme activity and CD4 ATP levels: prediction of acute rejection vs. viral replication events.
Pediatric transplantation. 15:229-8
2011
Immune Biomarker Panel Monitoring Utilizing Ido Enzyme Activity and Cd4 Atp Levels: Prediction of Both Extremes of Immunosuppression-Acute Rejection Or Viral Replication Events
American Journal of Transplantation. 11
2011
Lipid analysis of flat-mounted eye tissue by imaging mass spectrometry with identification of contaminants in preservation.
Analytical and bioanalytical chemistry. 401(1):103-13 [DOI] 10.1007/s00216-011-5044-x. [PMID] 21556752.
2011
Single incision laparoscopic colorectal surgery: a single surgeon experience of 102 consecutive cases.
Techniques in coloproctology. 15(4):397-401 [DOI] 10.1007/s10151-011-0756-7. [PMID] 21887555.
2010
Analysis of large peptides by MALDI using a linear quadrupole ion trap with mass range extension.
Analytical chemistry. 82(3):930-4 [DOI] 10.1021/ac9021488. [PMID] 20063857.
2010
Indoleamine 2,3-Dioxygenase (Ido) Immune Status Monitoring Post-Transplantation
American Journal of Transplantation. 10
2010
Indoleamine 2,3-Dioxygenase (Ido) Immune Status Monitoring Post-Transplantation
American Journal of Transplantation. 10
2010
Indoleamine 2,3-Dioxygenase (Ido)-Based Immune Status Monitoring Post-Transplantation.
American Journal of Transplantation. 10
2010
Tandem mass spectrometric methods for phospholipid analysis from brain tissue.
Methods in molecular biology (Clifton, N.J.). 656:209-30 [DOI] 10.1007/978-1-60761-746-4_12. [PMID] 20680593.
2009
Enhanced analysis of steroids by gas chromatography/mass spectrometry using microwave-accelerated derivatization.
Analytical chemistry. 81(16):6725-34 [DOI] 10.1021/ac900663c. [PMID] 19606839.
2009
Enhancement of chemical derivatization of steroids by gas chromatography/mass spectrometry (GC/MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 877(27):3237-42 [DOI] 10.1016/j.jchromb.2009.08.005. [PMID] 19692297.
2009
Evaluation of derivatization strategies for the comprehensive analysis of endocrine disrupting compounds using GC/MS.
Journal of chromatographic science. 47(1):44-51 [PMID] 19161656.
View on: PubMed
2009
Imaging of lipids in spinal cord using intermediate pressure matrix-assisted laser desorption-linear ion trap/Orbitrap MS.
Analytical chemistry. 81(20):8488-95 [DOI] 10.1021/ac901387u. [PMID] 19751051.
2009
Investigation of HPLC-MS using a monolithic column to separate a diverse suite of steroids.
Journal of chromatographic science. 47(1):52-6 [PMID] 19161657.
View on: PubMed
2009
Lipid geographical analysis of the primate macula by imaging mass spectrometry.
Methods in molecular biology (Clifton, N.J.). 579:247-60 [DOI] 10.1007/978-1-60761-322-0_12. [PMID] 19763479.
2007
Automated MALDI matrix deposition method with inkjet printing for imaging mass spectrometry.
Analytical chemistry. 79(17):6862-7 [PMID] 17658766.
View on: PubMed
2007
MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue.
Analytical chemistry. 79(21):8170-5 [PMID] 17894472.
View on: PubMed
2007
Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2′-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress.
Journal of chromatography. A. 1167(1):54-62 [PMID] 17765254.
View on: PubMed
2007
Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.
Journal of pharmacological and toxicological methods. 55(3):279-88 [PMID] 17222568.
View on: PubMed
2006
Analysis of intact tissue by intermediate-pressure MALDI on a linear ion trap mass spectrometer.
Analytical chemistry. 78(7):2465-9 [PMID] 16579637.
View on: PubMed
2006
Increased Arctic cloud longwave emissivity associated with pollution from mid-latitudes.
Nature. 440(7085):787-9 [PMID] 16598255.
View on: PubMed
2001
Reduction of paclitaxel-induced peripheral neuropathy with glutamine.
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(5):1192-7 [PMID] 11350883.
View on: PubMed
2001
State HIV/AIDS funding, programs affected by economic downturn.
AIDS policy & law. 16(16) [PMID] 11548535.
View on: PubMed
1998
High-dose thiotepa and etoposide-based regimens with autologous hematopoietic support for high-risk or recurrent CNS tumors in children and adults.
Bone marrow transplantation. 22(7):661-7 [PMID] 9818693.
View on: PubMed
1998
Phase I trial of sequential high-dose chemotherapy with escalating dose paclitaxel, melphalan, and cyclophosphamide, thiotepa, and carboplatin with peripheral blood progenitor support in women with responding metastatic breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(7):1689-95 [PMID] 9676843.
View on: PubMed
1998
The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant.
Cancer. 82(10):1978-87 [PMID] 9587133.
View on: PubMed
1993
Posttransplantation lymphoproliferative disorders treated with cyclophosphamide-doxorubicin-vincristine-prednisone chemotherapy.
Cancer. 72(9):2782-5 [PMID] 8402504.
View on: PubMed
1992
Structure and interactions of CD4.
Cold Spring Harbor symposia on quantitative biology. 57:541-8 [PMID] 1339691.
View on: PubMed
1986
Multiple myeloma masquerading as metastatic breast cancer.
Cancer. 57(5):923-4 [PMID] 3943026.
View on: PubMed
1984
Race, poverty, and survival in multiple myeloma.
Cancer. 54(12):3085-94 [PMID] 6498786.
View on: PubMed
1980
Fatal graft-versus-host disease following blood transfusion in Hodgkin’s disease documented by HLA typing.
Blood. 55(5):831-4 [PMID] 7362871.
View on: PubMed
1980
Studies in acute leukemia. II. Chemotaxis of leukemic blasts from patients with acute nonlymphoid leukemia: its relationship with IgG Fc receptors and role of surface-bound immunoglobulin.
International archives of allergy and applied immunology. 62(3):334-40 [PMID] 7390638.
View on: PubMed
1980
Subpopulations of human T lymphocytes. VI. Analysis of cell markers in acute lymphoblastic leukemia with special reference to Fc receptor expression on E-rosette-forming blasts.
Cancer. 46(1):45-9 [PMID] 6446375.
View on: PubMed
1979
Alteration in lymphoid chimerism associated with cytomegalovirus infection after bone marrow transplantation.
Transplantation. 28(3):253-6 [PMID] 227149.
View on: PubMed
1979
Studies in acute leukemia. I. Antibody-dependent and spontaneous cellular cytotoxicity by leukemic blasts from patients with acute nonlymphoid leukemia.
Blood. 54(3):573-80 [PMID] 288485.
View on: PubMed
1977
Cyclophosphamide L2 protocol: a combination chemotherapeutic regimen for advanced non-hodgkin’s lymphoma.
Cancer treatment reports. 61(1):7-16 [PMID] 861964.
View on: PubMed

Grants

Aug 2021 ACTIVE
Role of RORgt+ (note: g: is gamma symbol) lymphocytes in Gut Tissue Homeostasis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Aug 2021 ACTIVE
Lipidomic Atlas of nerve growth in X-deletion disorders
Role: Principal Investigator
Funding: XTRAORDINARY JOY FOUNDATION
Sep 2020 ACTIVE
Bacteria-associated VB12 regulates neonatal ileal epithelium homeostasis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2020 ACTIVE
DRPD-ROF2020: Determine the Metabolic Polymorphisms of American Cranberries to Prevent UTIs in Susceptible Women using an Integrated Metabolome-Microbiome Approach
Role: Co-Investigator
Funding: UF RESEARCH
Jun 2020 ACTIVE
Molecular mechanisms and pharmacologic targeting of lipogenesis in breast cancer
Role: Other
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Mar 2020 ACTIVE
Metabolomic Signature of PN Symptoms in Breast Cancer Over the First Year of Treatment and Survivorship
Role: Co-Investigator
Funding: NATL INST OF HLTH NINR
Mar 2020 – Jun 2021
Integrated transcriptomics and metabolomics approach to define pathogenicity of P.gingivalis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Jan 2019 ACTIVE
Gut dysbiosis and tryptophan metabolism in lupus
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Dec 2018 – Dec 2020
To expand Metabolome and Lipidome coverage by performing parallel studies in Sanofi internal labs and by SECIM
Role: Principal Investigator
Funding: SANOFI
Dec 2018 ACTIVE
Gut-brain axis: functional link between microbial metabolites and neurogenic hypertension
Role: Co-Investigator
Funding: NATL CTR FOR COMPLEM AND INTEGRATIVE HLT
Oct 2018 ACTIVE
Quantitative analysis of insulin activity in the cold supply chain
Role: Principal Investigator
Funding: JDRF
Aug 2018 ACTIVE
Metabolomics Consortium Coordinating Center (M3C)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
May 2018 – Oct 2020
Using Metabolomic Approaches to Investigate Treatments for Rare X-Chromosome Deletion Disorders
Role: Principal Investigator
Funding: XTRAORDINARY JOY FOUNDATION
Mar 2018 – Mar 2021
Targeting the lipogenic phenotype induced by extracellular acidosis in breast cancer
Role: Principal Investigator
Funding: H LEE MOFFITT CANCER CTR via FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Jun 2017 – May 2021
OR-DRPD-ROF2017:Combating resistant Gram-negative bacterial superbugs via omics techniques
Role: Co-Investigator
Funding: UF DSR OPPORTUNITY FUND
Sep 2016 – May 2021
An integrated, functional, molecular, and metabolomic approach to understand Oxalobacter-induced elimination of oxalate
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Aug 2016 – Jul 2017
Causes & Consequences of Acid pH in Tumors
Role: Principal Investigator
Funding: H LEE MOFFITT CANCER CTR via NATL INST OF HLTH NCI
Nov 2015 – Nov 2017
The Metabolomics of Oral Biofilms exposed to Arginine and Fluoride
Role: Project Manager
Funding: COLGATE-PALMOLIVE CO
Jul 2015 – Sep 2019
FlowProbe MS for Clinical Analysis
Role: Co-Investigator
Funding: PROSOLIA INC
Jul 2015 – May 2018
Regulation of tryptophan metabolism and anxiety by gut microbiota
Role: Project Manager
Funding: NATL INST OF HLTH NIMH
Jul 2015 – Jun 2021
Genetics and Physiology of Oral Biofilms
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Sep 2014 – May 2019
Ethnic Differences in Responses to Painful Stimuli
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Sep 2013 – Aug 2019
Southeast Resource Center for Integrated Metabolomics (SECIM)
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
Jul 2006 – Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS

Patents

Issued September 2018
Spraying System and Methods of Use Thereof (DIV of 13533)
#10,081,026
Issued February 2017
Spraying System and Methods of Use Thereof
#9,561,514

Teaching Profile

Courses Taught
2017-2019
EGN4912 Engineering Directed Independent Research
2018
CHM7979 Advanced Research
2018
GMS7979 Advanced Research
2018
CHM7980 Research for Doctoral Dissertation
2018
GMS7980 Research for Doctoral Dissertation

Contact Details

Phones:
Business:
(352) 273-5050
Emails:
Business:
tgarrett@ufl.edu