Marguerite Hatch

Marguerite Hatch,

PROFESSOR

Department: MD-PATHOLOGY
Business Phone: (352) 392-0013
Business Email: hatchma@ufl.edu

Publications

2021
Extracellular Vesicle Analysis by Paper Spray Ionization Mass Spectrometry.
Metabolites. 11(5) [DOI] 10.3390/metabo11050308. [PMID] 34065030.
2021
Forty Years of Oxalobacter formigenes, a Gutsy Oxalate-Degrading Specialist.
Applied and environmental microbiology. 87(18) [DOI] 10.1128/AEM.00544-21. [PMID] 34190610.
2021
The anion exchanger PAT-1 (Slc26a6) does not participate in oxalate or chloride transport by mouse large intestine.
Pflugers Archiv : European journal of physiology. 473(1):95-106 [DOI] 10.1007/s00424-020-02495-x. [PMID] 33205229.
2021
The role of NHE3 (Slc9a3) in oxalate and sodium transport by mouse intestine and regulation by cAMP.
Physiological reports. 9(7) [DOI] 10.14814/phy2.14828. [PMID] 33904662.
2020
Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6.
Urolithiasis. 48(1):1-8 [DOI] 10.1007/s00240-019-01144-y. [PMID] 31201468.
2020
Metabolomic Alteration in the Mouse Distal Colonic Mucosa after Oral Gavage with Oxalobacter formigenes.
Metabolites. 10(10) [DOI] 10.3390/metabo10100405. [PMID] 33065971.
2020
Oxalobacter formigenes produces metabolites and lipids undetectable in oxalotrophic Bifidobacterium animalis.
Metabolomics : Official journal of the Metabolomic Society. 16(12) [DOI] 10.1007/s11306-020-01747-2. [PMID] 33219444.
2019
125 Iodide as a surrogate tracer for epithelial chloride transport by the mouse large intestine in vitro.
Experimental physiology. 104(3):334-344 [DOI] 10.1113/EP087445. [PMID] 30615234.
2019
Absence of the sulfate transporter SAT-1 has no impact on oxalate handling by mouse intestine and does not cause hyperoxaluria or hyperoxalemia.
American journal of physiology. Gastrointestinal and liver physiology. 316(1):G82-G94 [DOI] 10.1152/ajpgi.00299.2018. [PMID] 30383413.
2019
Metabolomic and lipidomic characterization of Oxalobacter formigenes strains HC1 and OxWR by UHPLC-HRMS.
Analytical and bioanalytical chemistry. 411(19):4807-4818 [DOI] 10.1007/s00216-019-01639-y. [PMID] 30740635.
2019
Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri.
PloS one. 14(9) [DOI] 10.1371/journal.pone.0222393. [PMID] 31545840.
2019
Oxalate transport by the mouse intestine in vitro is not affected by chronic challenges to systemic acid-base homeostasis.
Urolithiasis. 47(3):243-254 [DOI] 10.1007/s00240-018-1067-5. [PMID] 29947993.
2017
Genome Sequence of Oxalobacter formigenes Strain HC-1
Genome announcements. 5(27) [DOI] 10.1128/genomeA.00533-17. [PMID] 28684568.
2017
Genome Sequence of Oxalobacter formigenes Strain OXCC13.
Genome announcements. 5(28) [DOI] 10.1128/genomeA.00534-17. [PMID] 28705966.
2017
Gut microbiota and oxalate homeostasis.
Annals of translational medicine. 5(2) [DOI] 10.21037/atm.2016.12.70. [PMID] 28217701.
2017
Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis.
American journal of physiology. Gastrointestinal and liver physiology. 313(3):G166-G179 [DOI] 10.1152/ajpgi.00079.2017. [PMID] 28526688.
2017
Oxalobacter formigenes colonization normalizes oxalate excretion in a gastric bypass model of hyperoxaluria.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 13(7):1152-1157 [DOI] 10.1016/j.soard.2017.03.014. [PMID] 28552742.
2017
The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man.
Urolithiasis. 45(1):89-108 [DOI] 10.1007/s00240-016-0952-z. [PMID] 27913853.
2016
The mechanistic basis of hyperoxaluria following gastric bypass in obese rats.
Urolithiasis. 44(3):221-30 [DOI] 10.1007/s00240-015-0836-7. [PMID] 26584912.
2015
Bifidobacterium animalis subsp. lactis decreases urinary oxalate excretion in a mouse model of primary hyperoxaluria.
Urolithiasis. 43(2):107-17 [DOI] 10.1007/s00240-014-0728-2. [PMID] 25269440.
2015
Chronic metabolic acidosis reduces urinary oxalate excretion and promotes intestinal oxalate secretion in the rat.
Urolithiasis. 43(6):489-99 [DOI] 10.1007/s00240-015-0801-5. [PMID] 26162424.
2015
Effects of acid-base variables and the role of carbonic anhydrase on oxalate secretion by the mouse intestine in vitro.
Physiological reports. 3(2) [DOI] 10.14814/phy2.12282. [PMID] 25716924.
2014
Acid-Base Regulation of Intestinal Oxalate Transport
The FASEB's Journal. 28(1, S)
2014
Intestinal adaptations in chronic kidney disease and the influence of gastric bypass surgery.
Experimental physiology. 99(9):1163-7 [DOI] 10.1113/expphysiol.2014.078782. [PMID] 24951497.
2014
Kidney stone incidence and metabolic urinary changes after modern bariatric surgery: review of clinical studies, experimental models, and prevention strategies.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 10(4):734-42 [DOI] 10.1016/j.soard.2014.03.026. [PMID] 24969092.
2013
A human strain of Oxalobacter (HC-1) promotes enteric oxalate secretion in the small intestine of mice and reduces urinary oxalate excretion.
Urolithiasis. 41(5):379-84 [PMID] 23959075.
View on: PubMed
2013
Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate.
The Journal of urology. 190(3):1102-9 [DOI] 10.1016/j.juro.2013.02.3229. [PMID] 23499748.
2013
Sulfate secretion and chloride absorption are mediated by the anion exchanger DRA (Slc26a3) in the mouse cecum.
American journal of physiology. Gastrointestinal and liver physiology. 305(2):G172-84 [DOI] 10.1152/ajpgi.00084.2013. [PMID] 23660504.
2013
Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate.
American journal of physiology. Gastrointestinal and liver physiology. 305(7):G520-7 [DOI] 10.1152/ajpgi.00167.2013. [PMID] 23886857.
2012
Hyperoxaluric rats do not exhibit alterations in renal expression patterns of Slc26a1 (SAT1) mRNA or protein.
Urological research. 40(6):647-54 [DOI] 10.1007/s00240-012-0480-4. [PMID] 22573180.
2011
Enteric oxalate elimination is induced and oxalate is normalized in a mouse model of primary hyperoxaluria following intestinal colonization with Oxalobacter.
American journal of physiology. Gastrointestinal and liver physiology. 300(3):G461-9 [DOI] 10.1152/ajpgi.00434.2010. [PMID] 21163900.
2010
Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
Journal of pediatric gastroenterology and nutrition. 51(4):414-7 [DOI] 10.1097/MPG.0b013e3181dd913a. [PMID] 20706153.
2009
Parsing Apical Oxalate Exchange in Caco-2Bbe1 Monolayers: Sirna Knockdown of Slc26A6 Reveals the Role and Properties of Pat-1
American Journal of Physiology-Gastrointestinal and Liver Physiology. 297(1):G918-G929 [DOI] 10.1152/ajpgi.00251.2009. [PMID] 11744674.
2009
Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1.
American journal of physiology. Gastrointestinal and liver physiology. 297(5):G918-29 [PMID] 20501439.
View on: PubMed
2008
Enteric oxalate secretion is not directly mediated by the human CFTR chloride channel.
Urological research. 36(3-4):127-31 [DOI] 10.1007/s00240-008-0142-8. [PMID] 18563405.
2008
Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism.
American journal of physiology. Gastrointestinal and liver physiology. 295(2):G348-56 [DOI] 10.1152/ajpgi.00079.2008. [PMID] 18535292.
2008
The roles and mechanisms of intestinal oxalate transport in oxalate homeostasis.
Seminars in nephrology. 28(2):143-51 [DOI] 10.1016/j.semnephrol.2008.01.007. [PMID] 18359395.
2006
Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice.
American journal of physiology. Gastrointestinal and liver physiology. 290(4):G719-28 [PMID] 16373425.
View on: PubMed
2006
Oxalobacter sp. reduces urinary oxalate excretion by promoting enteric oxalate secretion.
Kidney international. 69(4):691-8 [PMID] 16518326.
View on: PubMed
2005
Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.
Journal of pediatric gastroenterology and nutrition. 40(5):589-95 [PMID] 15861021.
View on: PubMed
2005
Ethylene glycol induces hyperoxaluria without metabolic acidosis in rats.
American journal of physiology. Renal physiology. 289(3):F536-43 [PMID] 15855660.
View on: PubMed
2005
Intestinal transport of an obdurate anion: oxalate.
Urological research. 33(1):1-16 [PMID] 15565438.
View on: PubMed
2005
Lipid peroxidation is not the underlying cause of renal injury in hyperoxaluric rats.
Kidney international. 68(6):2629-38 [PMID] 16316339.
View on: PubMed
2004
Serum oxalate in human beings and rats as determined with the use of ion chromatography.
The Journal of laboratory and clinical medicine. 144(1):45-52 [PMID] 15252407.
View on: PubMed
2003
Angiotensin II involvement in adaptive enteric oxalate excretion in rats with chronic renal failure induced by hyperoxaluria.
Urological research. 31(6):426-32 [PMID] 14574528.
View on: PubMed
2003
Renal and intestinal handling of oxalate following oxalate loading in rats.
American journal of nephrology. 23(1):18-26 [PMID] 12373077.
View on: PubMed

Grants

Mar 2017 ACTIVE
Intestinal oxalate transport and the regulation of the apical Slc26 anion exchangers involved
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2016 – May 2021
An integrated, functional, molecular, and metabolomic approach to understand Oxalobacter-induced elimination of oxalate
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2015 – Aug 2016
An integrated, functional, molecular, and metabolomic approach to understand Oxalobacter-induced elimination of oxalate
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2010 – Aug 2016
Probiotic-Induced Elimination of Oxalate to Treat Hyperoxaluria Associated with Primary Hyperoxaluria and Bariatric Surgery
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK

Teaching Profile

Courses Taught
2018
GMS7980 Research for Doctoral Dissertation
2014-2017
GMS6003 Fundamentals of Graduate Research and Professional Development
2009-2010
IDH4917 Undergrad Research
2006,2008
GMS6381 Spec Topics Pathology

Contact Details

Phones:
Business:
(352) 392-0013
Emails:
Business:
hatchma@ufl.edu
Administrative Asst:
Linda S Harlan
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