Saeed R Khan,
Emeritus Prof
Teaching Profile
Courses Taught
2008
GMS6381 Spec Topics Pathology
Publications
2023
Proposal for pathogenesis-based treatment options to reduce calcium oxalate stone recurrence.
Asian journal of urology.
10(3):246-257
[DOI] 10.1016/j.ajur.2023.01.008.
[PMID] 37538166.
2021
Antiurolithic effects of medicinal plants: results of in vivo studies in rat models of calcium oxalate nephrolithiasis-a systematic review.
Urolithiasis.
49(2):95-122
[DOI] 10.1007/s00240-020-01236-0.
[PMID] 33484322.
2021
Editorial: Immunity and Inflammatory Response in Kidney Stone Disease.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.795559.
[PMID] 34790209.
2021
Randall’s plaque and calcium oxalate stone formation: role for immunity and inflammation.
Nature reviews. Nephrology.
17(6):417-433
[DOI] 10.1038/s41581-020-00392-1.
[PMID] 33514941.
2020
Immunotherapy for stone disease.
Current opinion in urology.
30(2):183-189
[DOI] 10.1097/MOU.0000000000000729.
[PMID] 31913203.
2019
Development of a two-stage in vitro model system to investigate the mineralization mechanisms involved in idiopathic stone formation: stage 1-biomimetic Randall’s plaque using decellularized porcine kidneys.
Urolithiasis.
47(4):321-334
[DOI] 10.1007/s00240-018-1060-z.
[PMID] 29777258.
2019
Development of a two-stage model system to investigate the mineralization mechanisms involved in idiopathic stone formation: stage 2 in vivo studies of stone growth on biomimetic Randall’s plaque.
Urolithiasis.
47(4):335-346
[DOI] 10.1007/s00240-018-1079-1.
[PMID] 30218116.
2019
NADPH oxidase: a therapeutic target for hyperoxaluria-induced oxidative stress – an update.
Future medicinal chemistry.
11(23):2975-2978
[DOI] 10.4155/fmc-2019-0275.
[PMID] 31659918.
2019
Opportunities for future therapeutic interventions for hyperoxaluria: targeting oxidative stress.
Expert opinion on therapeutic targets.
23(5):379-391
[DOI] 10.1080/14728222.2019.1599359.
[PMID] 30905219.
2018
Calcium Oxalate Differentiates Human Monocytes Into Inflammatory M1 Macrophages.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.01863.
[PMID] 30186283.
2018
Development of a personalized diagnostic model for kidney stone disease tailored to acute care by integrating large clinical, demographics and laboratory data: the diagnostic acute care algorithm – kidney stones (DACA-KS).
BMC medical informatics and decision making.
18(1)
[DOI] 10.1186/s12911-018-0652-4.
[PMID] 30119627.
2018
Modulation of calcium oxalate dihydrate growth by phosphorylated osteopontin peptides.
Journal of structural biology.
204(2):131-144
[DOI] 10.1016/j.jsb.2018.07.010.
[PMID] 30016645.
2017
Histological aspects of the “fixed-particle” model of stone formation: animal studies.
Urolithiasis.
45(1):75-87
[DOI] 10.1007/s00240-016-0949-7.
[PMID] 27896391.
2017
How do stones form? Is unification of theories on stone formation possible?
Archivos espanoles de urologia.
70(1):12-27
[PMID] 28221139.
2017
Kidney stones.
Nature reviews. Disease primers.
3
[DOI] 10.1038/nrdp.2017.1.
[PMID] 28079115.
2017
Pathogenesis of calcium oxalate urinary stone disease: species comparison of humans, dogs, and cats.
Urolithiasis.
45(4):329-336
[DOI] 10.1007/s00240-017-0978-x.
[PMID] 28361470.
2017
Transcriptional study of hyperoxaluria and calcium oxalate nephrolithiasis in male rats: Inflammatory changes are mainly associated with crystal deposition.
PloS one.
12(11)
[DOI] 10.1371/journal.pone.0185009.
[PMID] 29091707.
2016
Calcium Oxalate Stone Fragment and Crystal Phagocytosis by Human Macrophages.
The Journal of urology.
195(4 Pt 1):1143-51
[DOI] 10.1016/j.juro.2015.11.048.
[PMID] 26626217.
2016
Involvement of renin-angiotensin-aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury.
World journal of urology.
34(1):89-95
[DOI] 10.1007/s00345-015-1563-y.
[PMID] 25981400.
2016
Kidney stones.
Nature reviews. Disease primers.
2
[DOI] 10.1038/nrdp.2016.8.
[PMID] 27188687.
2016
Role of Osteogenesis in the Formation of Randall’s Plaques.
Anatomical record (Hoboken, N.J. : 2007).
299(1):5-7
[DOI] 10.1002/ar.23275.
[PMID] 26414710.
2015
Activation of the NLRP3 inflammasome in association with calcium oxalate crystal induced reactive oxygen species in kidneys.
The Journal of urology.
193(5):1684-91
[DOI] 10.1016/j.juro.2014.11.093.
[PMID] 25437532.
2015
Osteogenic changes in kidneys of hyperoxaluric rats.
Biochimica et biophysica acta.
1852(9):2000-12
[DOI] 10.1016/j.bbadis.2015.06.020.
[PMID] 26122267.
2015
The role of Randall’s plaques in urolithiasis. Foreword.
Urolithiasis.
43 Suppl 1(0 1):1-3
[DOI] 10.1007/s00240-014-0721-9.
[PMID] 25218780.
2015
Unified theory on the pathogenesis of Randall’s plaques and plugs.
Urolithiasis.
43 Suppl 1(0 1):109-23
[DOI] 10.1007/s00240-014-0705-9.
[PMID] 25119506.
2014
Breast-cancer risk in families with mutations in PALB2.
The New England journal of medicine.
371(6):497-506
[DOI] 10.1056/NEJMoa1400382.
[PMID] 25099575.
2014
Calcium oxalate nephrolithiasis and expression of matrix GLA protein in the kidneys.
World journal of urology.
32(1):123-30
[DOI] 10.1007/s00345-013-1050-2.
[PMID] 23475213.
2014
Exposure of Madin-Darby canine kidney (MDCK) cells to oxalate and calcium oxalate crystals activates nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase.
Urology.
83(2):510.e1-7
[DOI] 10.1016/j.urology.2013.10.038.
[PMID] 24360063.
2014
Osteopontin knockdown in the kidneys of hyperoxaluric rats leads to reduction in renal calcium oxalate crystal deposition.
Urolithiasis.
42(3):195-202
[DOI] 10.1007/s00240-014-0649-0.
[PMID] 24619192.
2014
Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis.
Translational andrology and urology.
3(3):256-276
[PMID] 25383321.
2014
Regulation of macromolecular modulators of urinary stone formation by reactive oxygen species: transcriptional study in an animal model of hyperoxaluria.
American journal of physiology. Renal physiology.
306(11):F1285-95
[DOI] 10.1152/ajprenal.00057.2014.
[PMID] 24598804.
2013
Editorial comment.
Urology.
82(2)
[DOI] 10.1016/j.urology.2013.03.066.
[PMID] 23796397.
2013
NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys.
Oxidative medicine and cellular longevity.
2013
[DOI] 10.1155/2013/462361.
[PMID] 23840917.
2013
Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: evidence from clinical and experimental investigations.
The Journal of urology.
189(3):803-11
[DOI] 10.1016/j.juro.2012.05.078.
[PMID] 23022011.
2013
Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate.
The Journal of urology.
190(3):1102-9
[DOI] 10.1016/j.juro.2013.02.3229.
[PMID] 23499748.
2013
Stress Oxidative: Nephrolithiasis and Chronic Kidney Diseases
Minerva Medica.
104:23-30
2013
The kidney sodium-phosphate co-transporter alters bone quality in an age and gender specific manner.
Bone.
53(2):546-53
[DOI] 10.1016/j.bone.2013.01.011.
[PMID] 23333524.
2012
Apocynin-treatment reverses hyperoxaluria induced changes in NADPH oxidase system expression in rat kidneys: a transcriptional study.
PloS one.
7(10)
[DOI] 10.1371/journal.pone.0047738.
[PMID] 23091645.
2012
Association of Randall plaque with collagen fibers and membrane vesicles.
The Journal of urology.
187(3):1094-100
[DOI] 10.1016/j.juro.2011.10.125.
[PMID] 22266007.
2012
Is oxidative stress, a link between nephrolithiasis and obesity, hypertension, diabetes, chronic kidney disease, metabolic syndrome?
Urological research.
40(2):95-112
[DOI] 10.1007/s00240-011-0448-9.
[PMID] 22213019.
2012
Renal glomerular and tubular injury after gastric bypass in obese rats.
Nutrition (Burbank, Los Angeles County, Calif.).
28(1):76-80
[DOI] 10.1016/j.nut.2011.03.003.
[PMID] 21723091.
2012
Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica.
Urological research.
40(6):671-81
[DOI] 10.1007/s00240-012-0483-1.
[PMID] 22622371.
2011
Antiurolithic activity of Origanum vulgare is mediated through multiple pathways.
BMC complementary and alternative medicine.
11
[DOI] 10.1186/1472-6882-11-96.
[PMID] 22004514.
2011
Crystal/cell interaction and nephrolithiasis.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica.
83(1):1-5
[PMID] 21585160.
2011
Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
26(6):1785-96
[DOI] 10.1093/ndt/gfr035.
[PMID] 21378157.
2011
Experimentally induced hyperoxaluria in MCP-1 null mice.
Urological research.
39(4):253-8
[DOI] 10.1007/s00240-010-0345-7.
[PMID] 21161647.
2011
Prevention of renal crystal deposition by an extract of Ammi visnaga L. and its constituents khellin and visnagin in hyperoxaluric rats.
Urological research.
39(3):189-95
[DOI] 10.1007/s00240-010-0333-y.
[PMID] 21069311.
2011
Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.
PloS one.
6(8)
[DOI] 10.1371/journal.pone.0023888.
[PMID] 21909374.
2011
Temporal changes in the expression of mRNA of NADPH oxidase subunits in renal epithelial cells exposed to oxalate or calcium oxalate crystals.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
26(6):1778-85
[DOI] 10.1093/ndt/gfq692.
[PMID] 21079197.
2011
Ultrastructural investigation of crystal deposits in Npt2a knockout mice: are they similar to human Randall’s plaques?
The Journal of urology.
186(3):1107-13
[DOI] 10.1016/j.juro.2011.04.109.
[PMID] 21784483.
2011
α,β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells.
Journal of medicinal chemistry.
54(2):449-56
[DOI] 10.1021/jm100589p.
[PMID] 21186794.
2010
An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
17(8-9):653-8
[DOI] 10.1016/j.phymed.2009.10.011.
[PMID] 20036111.
2010
Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats.
Phytotherapy research : PTR.
24(8):1250-5
[DOI] 10.1002/ptr.3196.
[PMID] 20564494.
2010
Experimental induction of calcium oxalate nephrolithiasis in mice.
The Journal of urology.
184(3):1189-96
[DOI] 10.1016/j.juro.2010.04.065.
[PMID] 20663521.
2010
Mineralogical signatures of stone formation mechanisms.
Urological research.
38(4):281-92
[DOI] 10.1007/s00240-010-0288-z.
[PMID] 20625894.
2010
Nephrocalcinosis in animal models with and without stones.
Urological research.
38(6):429-38
[DOI] 10.1007/s00240-010-0303-4.
[PMID] 20658131.
2010
Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein.
American journal of physiology. Renal physiology.
299(3):F469-78
[DOI] 10.1152/ajprenal.00243.2010.
[PMID] 20591941.
2010
Reduced-intensity conditioning using fludarabine with either antithymocyte globulin and BU, or low-dose TBI allowing allogeneic hematopoietic SCT.
Bone marrow transplantation.
45(1):31-7
[DOI] 10.1038/bmt.2009.126.
[PMID] 19543325.
2009
Genetic basis of renal cellular dysfunction and the formation of kidney stones.
Urological research.
37(4):169-80
[DOI] 10.1007/s00240-009-0201-9.
[PMID] 19517103.
2009
Herbal medicines in the management of urolithiasis: alternative or complementary?
Planta medica.
75(10):1095-103
[DOI] 10.1055/s-0029-1185719.
[PMID] 19444769.
2009
Mechanism of formation of concentrically laminated spherules: implication to Randall’s plaque and stone formation.
Urological research.
37(1):11-7
[DOI] 10.1007/s00240-008-0169-x.
[PMID] 19066874.
2009
Superoxide from NADPH oxidase as second messenger for the expression of osteopontin and monocyte chemoattractant protein-1 in renal epithelial cells exposed to calcium oxalate crystals.
BJU international.
104(1):115-20
[DOI] 10.1111/j.1464-410X.2009.08374.x.
[PMID] 19220254.
2009
The effect of calcium on calcium oxalate monohydrate crystal-induced renal epithelial injury.
Urological research.
37(1):1-6
[DOI] 10.1007/s00240-008-0160-6.
[PMID] 19005647.
2008
A tribute to the life and accomplishments of Birdwell Finlayson.
The Journal of urology.
179(3):842-6; discussion 846
[DOI] 10.1016/j.juro.2007.10.052.
[PMID] 18221959.
2008
Apatite induced renal epithelial injury: insight into the pathogenesis of kidney stones.
The Journal of urology.
180(1):379-87
[DOI] 10.1016/j.juro.2008.02.041.
[PMID] 18499159.
2008
Calcium oxalate crystal deposition in kidneys of hypercalciuric mice with disrupted type IIa sodium-phosphate cotransporter.
American journal of physiology. Renal physiology.
294(5):F1109-15
[DOI] 10.1152/ajprenal.00620.2007.
[PMID] 18337544.
2008
Direct AFM measurements of adhesion forces between calcium oxalate monohydrate and kidney epithelial cells in the presence of Ca2+ and Mg2+ ions.
Journal of colloid and interface science.
325(2):594-601
[DOI] 10.1016/j.jcis.2008.06.024.
[PMID] 18619606.
2008
Prevention of Nephrolithiasis By An Extract of Ammi Visnaga L, in Stone Forming Rats
Planta Medica.
74
2007
Dietary oxalate and calcium oxalate nephrolithiasis.
The Journal of urology.
178(5):2191-6
[PMID] 17870111.
2007
Naturally produced crystals obtained from kidney stones are less injurious to renal tubular epithelial cells than synthetic crystals.
BJU international.
100(4):891-7
[PMID] 17550416.
2006
Adhesion force between calcium oxalate monohydrate crystal and kidney epithelial cells and possible relevance for kidney stone formation.
Journal of colloid and interface science.
300(1):131-40
[PMID] 16677664.
2006
Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline.
Kidney international.
70(5):914-23
[PMID] 16850024.
2006
Oxalate ions and calcium oxalate crystal-induced up-regulation of osteopontin and monocyte chemoattractant protein-1 in renal fibroblasts.
BJU international.
98(3):656-60
[PMID] 16925768.
2006
Re: Dietary oxalate loads and renal oxalate handling. R. P. Holmes, W. T. Ambrosius and D. G. Assimos.
The Journal of urology.
175(4):1576; author reply 1576-7
[PMID] 16516052.
2006
Reactive oxygen species mediated calcium oxalate crystal-induced expression of MCP-1 in HK-2 cells.
Urological research.
34(1):26-36
[PMID] 16397773.
2006
Renal tubular damage/dysfunction: key to the formation of kidney stones.
Urological research.
34(2):86-91
[PMID] 16404622.
2006
Role of lipids in urinary stones: studies of calcium oxalate precipitation at phospholipid langmuir monolayers.
Langmuir : the ACS journal of surfaces and colloids.
22(6):2450-6
[PMID] 16519440.
2005
Atomic force microscopy measurement of the elastic properties of the kidney epithelial cells.
Journal of Colloid and Interface Science.
285(1):125-35
[DOI] 10.1016/j.jcis.2004.11.041.
[PMID] 15797405.
2005
Citrate and vitamin E blunt the shock wave-induced free radical surge in an in vitro cell culture model.
Urological research.
33(6):448-52
[PMID] 16317535.
2005
Citrate provides protection against oxalate and calcium oxalate crystal induced oxidative damage to renal epithelium.
The Journal of urology.
173(2):640-6
[PMID] 15643280.
2005
Diphenyleneiodium (DPI) reduces oxalate ion- and calcium oxalate monohydrate and brushite crystal-induced upregulation of MCP-1 in NRK 52E cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
20(5):870-8
[PMID] 15755756.
2005
Hyperoxaluria-induced oxidative stress and antioxidants for renal protection.
Urological research.
33(5):349-57
[PMID] 16292585.
2005
Oxalate induced expression of monocyte chemoattractant protein-1 (MCP-1) in HK-2 cells involves reactive oxygen species.
Urological research.
33(6):440-7
[PMID] 16307291.
2005
Oxalate-inducible AMBP gene and its regulatory mechanism in renal tubular epithelial cells.
The Biochemical journal.
387(Pt 3):609-16
[PMID] 15533056.
2004
Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studies.
Clinical and experimental nephrology.
8(2):75-88
[PMID] 15235923.
2004
Effect of angiotensin II receptor blockage on osteopontin expression and calcium oxalate crystal deposition in rat kidneys.
Journal of the American Society of Nephrology : JASN.
15(3):635-44
[PMID] 14978165.
2004
Modulators of urinary stone formation.
Frontiers in bioscience : a journal and virtual library.
9:1450-82
[PMID] 14977559.
2004
Role of renal epithelial cells in the initiation of calcium oxalate stones.
Nephron. Experimental nephrology.
98(2):e55-60
[PMID] 15499208.
2003
Calcium phosphate-induced renal epithelial injury and stone formation: involvement of reactive oxygen species.
Kidney international.
64(4):1283-91
[PMID] 12969146.
2003
Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
18(4):664-9
[PMID] 12637633.
2003
Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants.
Urological research.
31(1):3-9
[PMID] 12624656.
2003
Protective role of heparin/heparan sulfate on oxalate-induced changes in cell morphology and intracellular Ca2+.
Urological research.
31(3):198-206
[PMID] 12719948.
2002
Aggregation and dispersion characteristics of calcium oxalate monohydrate: effect of urinary species.
Journal of colloid and interface science.
256(1):168-74
[PMID] 12505509.
2002
Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis.
The Journal of urology.
168(3):1173-81
[PMID] 12187263.
2002
Oxalate ions and calcium oxalate crystals stimulate MCP-1 expression by renal epithelial cells.
Kidney international.
61(1):105-12
[PMID] 11786090.
2002
Presence of lipids in urine, crystals and stones: implications for the formation of kidney stones.
Kidney international.
62(6):2062-72
[PMID] 12427130.
2002
Quantification of proteins extracted from calcium oxalate and calcium phosphate crystals induced in vitro in the urine of healthy controls and stone-forming patients.
Urologia internationalis.
68(1):54-9
[PMID] 11803269.
2002
Stone research on the bench: where we are and where we are going.
Journal of endourology.
16(6):413-6
[PMID] 12227916.
2000
Nephrolithiasis: a consequence of renal epithelial cell exposure to oxalate and calcium oxalate crystals.
Molecular Urology.
4(4):305-12
[PMID] 11156696.
1999
Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells.
Journal of the American Society of Nephrology.
10 Suppl 14:S457-63
[PMID] 10541283.
Grants
Aug 2013
– Jul 2018
Training Program in Urologic Research
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
May 2012
– Apr 2017
An In Vitro Model for Studying the Role of Acidic Proteins in Randalls Plaque and Stone Formation
Role: Project Manager
Funding: NATL INST OF HLTH
Contact Details
Phones:
- Business:
- (352) 392-3574
Emails:
- Business:
- khan@pathology.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100275
GAINESVILLE FL 32610 - Business Street:
-
D6-33C DSB
GAINESVILLE FL 32611