Ryan H Kolb,
AST PROF
Teaching Profile
Courses Taught
2022-2025
GMS6647 Transcriptional and Translational Control of Cell Growth and Proliferation
2023-2025
GMS6921 Immunology/Microbiology Journal Colloquy
2023-2025
GMS6140 Principles of Immunology
Research Profile
Areas of Interest
- Breast Cancers
- Cancer
- Cancer Immunotherapy
- Inflammation
- Obesity
Publications
Academic Articles
2024
ANGPTL4 Suppresses Clear Cell Renal Cell Carcinoma via Inhibition of Lysosomal Acid Lipase
Cancer Research Communications.
4(8):2242-2254
[DOI] 10.1158/2767-9764.crc-24-0016.
2024
Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.04.25.591178.
[PMID] 38712046.
2024
Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren’s disease.
Communications biology.
7(1)
[DOI] 10.1038/s42003-024-06124-6.
[PMID] 38641668.
2023
Correction: ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation.
PloS one.
18(9)
[DOI] 10.1371/journal.pone.0292423.
[PMID] 37769019.
2023
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy.
Life medicine.
2(3)
[DOI] 10.1093/lifemedi/lnad019.
[PMID] 39872303.
2022
Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications.
Cancers.
14(13)
[DOI] 10.3390/cancers14133287.
[PMID] 35805056.
2021
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Nature communications.
12(1)
[DOI] 10.1038/s41467-021-26091-4.
[PMID] 34599187.
2021
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells.
Nature communications.
12(1)
[DOI] 10.1038/s41467-021-21573-x.
[PMID] 33627663.
2021
Updates on Immunotherapy and Immune Landscape in Renal Clear Cell Carcinoma.
Cancers.
13(22)
[DOI] 10.3390/cancers13225856.
[PMID] 34831009.
2020
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling.
Oncogene.
39(14):2877-2889
[DOI] 10.1038/s41388-020-1203-x.
[PMID] 32042113.
2020
IL-1 Signaling in Tumor Microenvironment.
Advances in experimental medicine and biology.
1240:1-23
[DOI] 10.1007/978-3-030-38315-2_1.
[PMID] 32060884.
2020
Obesity and Breast Cancer: A Case of Inflamed Adipose Tissue.
Cancers.
12(6)
[DOI] 10.3390/cancers12061686.
[PMID] 32630445.
2019
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4.
Oncogene.
38(13):2351-2363
[DOI] 10.1038/s41388-018-0592-6.
[PMID] 30518876.
2019
ROR1 Potentiates FGFR Signaling in Basal-Like Breast Cancer.
Cancers.
11(5)
[DOI] 10.3390/cancers11050718.
[PMID] 31137681.
2015
A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation.
Oncogene.
34(17):2215-26
[DOI] 10.1038/onc.2014.167.
[PMID] 24909175.
2012
ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.
PloS one.
7(11)
[DOI] 10.1371/journal.pone.0050281.
[PMID] 23166842.
2012
RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation.
Breast cancer research : BCR.
14(2)
[PMID] 22494620.
2010
Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response.
Oncogene.
29(30):4317-29
[DOI] 10.1038/onc.2010.187.
[PMID] 20498628.
2008
Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1.
Cancer research.
68(13):5113-21
[DOI] 10.1158/0008-5472.CAN-07-5818.
[PMID] 18593910.
1991
Effects of atenolol alone, nifedipine alone and their combination on ambulant myocardial ischemia.
The American journal of cardiology.
67(8):671-5
[PMID] 2006616.
Grants
Jan 2025
ACTIVE
The role of Angiopoietin-like 4 in clear cell renal cell carcinoma and its therapeutic potential
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Apr 2024
ACTIVE
Proteolysis targeting chimera against nuclear receptor NR4A1 for melanoma therapy
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jan 2022
ACTIVE
American Cancer Society Institutional Research Grant
Role: Project Manager
Funding: AMERICAN CANCER SOCIETY
Mar 2020
– Feb 2023
Targeting ANGPTL4 in obesity-driven breast cancer progression
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Apr 2019
– Mar 2023
Modulating Cancer Genetics for Immune Regulation and Breast Cancer Therapy
Role: Other
Funding: US ARMY MED RES ACQUISITION
Mar 2019
– Jun 2022
CD177 suppresses breast-cancer development by inhibiting beta-catenin
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Dec 2015
– Nov 2021
Obesity, inflammation and breast cancer
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Contact Details
Phones:
- Business:
- (352) 273-6834
Emails:
- Business:
- ryankolb@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100275
GAINESVILLE FL 32610