Laurence M Morel

Laurence M Morel, PhD

PROFESSOR

Department: MD-PATHOLOGY
Business Phone: (352) 392-3790
Business Email: morel@pathology.ufl.edu

Research Profile

Laurence Morel obtained her PhD from the University of Aix-Marseille (France). She trained as a postdoctoral fellow with Dr. Ward Wakeland at the University of Florida (USA) in immunogenetics, where she started to work on the genetic basis of lupus in mouse models. She was appointed with a faculty position in the department of Pathology, Immunology, and Laboratory Medicine at UF in 1999, where she is currently a tenured professor and the Vice Chair for Research and Academic Affairs. Her research is centered on the mechanisms of lupus pathogenesis using mouse models as well as patients’ samples. She has been continuously funded by the NIH, as well as by the Lupus Research Alliance and the Lupus Foundation for America. She is an expert in mouse models of autoimmune diseases and she has written several reviews on the mouse models of lupus. Her current research focuses on the genetic and metabolic determinants of lupus phenotypes in CD4+ T cells, as well as the role of the microbiome in lupus pathogenesis. She is also conducting pre-clinical studies to explore the therapeutic potentials of treatments combining metabolic inhibitors to standard-of-care or emerging biologics. Her long-term goal is to identify and validate therapeutic targets using a combination of genetic, metabolic and microbial / metabolomics approaches.

Publications

2021
D-mannose ameliorates autoimmune phenotypes in mouse models of lupus.
BMC immunology. 22(1) [DOI] 10.1186/s12865-020-00392-7. [PMID] 33402096.
2021
Emergency myelopoiesis contributes to immune cell exhaustion and pulmonary vascular remodelling.
British journal of pharmacology. 178(1):187-202 [DOI] 10.1111/bph.14945. [PMID] 31793661.
2021
Iron Metabolism: An Under Investigated Driver of Renal Pathology in Lupus Nephritis.
Frontiers in medicine. 8 [DOI] 10.3389/fmed.2021.643686. [PMID] 33912577.
2021
Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
JCI insight. 6(14) [DOI] 10.1172/jci.insight.143540. [PMID] 34156979.
2021
Promise and complexity of lupus mouse models.
Nature immunology. 22(6):683-686 [DOI] 10.1038/s41590-021-00914-4. [PMID] 33972783.
2021
Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-86017-4. [PMID] 33737712.
2020
Effects of metformin on disease flares in patients with systemic lupus erythematosus: post hoc analyses from two randomised trials.
Lupus science & medicine. 7(1) [DOI] 10.1136/lupus-2020-000429. [PMID] 33093216.
2020
Efficacy of the Combination of Metformin and CTLA4Ig in the (NZB × NZW)F1 Mouse Model of Lupus Nephritis.
ImmunoHorizons. 4(6):319-331 [DOI] 10.4049/immunohorizons.2000033. [PMID] 32540987.
2020
Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice.
Science translational medicine. 12(551) [DOI] 10.1126/scitranslmed.aax2220. [PMID] 32641487.
2020
Immune metabolism regulation of the germinal center response.
Experimental & molecular medicine. 52(3):348-355 [DOI] 10.1038/s12276-020-0392-2. [PMID] 32132626.
2020
Immunophenotyping reveals distinct subgroups of lupus patients based on their activated T cell subsets.
Clinical immunology (Orlando, Fla.). 221 [DOI] 10.1016/j.clim.2020.108602. [PMID] 33007439.
2020
Intestinal Dysbiosis and Tryptophan Metabolism in Autoimmunity.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.01741. [PMID] 32849620.
2020
Metabolic determinants of lupus pathogenesis.
Immunological reviews. 295(1):167-186 [DOI] 10.1111/imr.12847. [PMID] 32162304.
2020
Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation.
Mucosal immunology. 13(1):34-46 [DOI] 10.1038/s41385-019-0210-0. [PMID] 31619761.
2020
T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice.
JCI insight. 5(11) [DOI] 10.1172/jci.insight.138274. [PMID] 32493841.
2020
Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells.
Molecular therapy : the journal of the American Society of Gene Therapy. 28(3):758-770 [DOI] 10.1016/j.ymthe.2019.11.011. [PMID] 31780366.
2019
A Variant of the Histone-Binding Protein sNASP Contributes to Mouse Lupus.
Frontiers in immunology. 10 [DOI] 10.3389/fimmu.2019.00637. [PMID] 31001259.
2019
Alpha-1-Antitrypsin Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice.
Journal of clinical medicine. 8(9) [DOI] 10.3390/jcm8091341. [PMID] 31470606.
2019
Editorial: Mechanisms by Which SLE-Associated Genetic Variants Contribute to SLE Pathogenesis.
Frontiers in immunology. 10 [DOI] 10.3389/fimmu.2019.02808. [PMID] 31849982.
2019
Immune cell metabolism in autoimmunity.
Clinical and experimental immunology. 197(2):181-192 [DOI] 10.1111/cei.13277. [PMID] 30770544.
2019
Metabolic regulation of pathogenic autoimmunity: therapeutic targeting.
Current opinion in immunology. 61:10-16 [DOI] 10.1016/j.coi.2019.07.001. [PMID] 31422315.
2019
Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells.
Journal of immunology (Baltimore, Md. : 1950). 203(2):338-348 [DOI] 10.4049/jimmunol.1801651. [PMID] 31160534.
2019
Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer.
Cellular immunology. 342 [DOI] 10.1016/j.cellimm.2017.07.012. [PMID] 28888664.
2019
Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters.
Frontiers in immunology. 10 [DOI] 10.3389/fimmu.2019.00833. [PMID] 31057554.
2018
Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice.
Molecular therapy. Methods & clinical development. 11:131-142 [DOI] 10.1016/j.omtm.2018.10.007. [PMID] 30547047.
2018
Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.02789. [PMID] 30555474.
2018
Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection.
Pathogens and disease. 76(8) [DOI] 10.1093/femspd/fty076. [PMID] 30351354.
2018
Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-06686-0. [PMID] 30348969.
2018
Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01973. [PMID] 30233578.
2018
Proliferation of hippocampal progenitors relies on p27-dependent regulation of Cdk6 kinase activity.
Cellular and molecular life sciences : CMLS. 75(20):3817-3827 [DOI] 10.1007/s00018-018-2832-x. [PMID] 29728713.
2018
Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01053. [PMID] 29868014.
2018
Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4+ T Cell Polarization.
Journal of immunology (Baltimore, Md. : 1950). 200(9):3087-3099 [DOI] 10.4049/jimmunol.1701179. [PMID] 29563177.
2017
A Skint6 allele potentially contributes to mouse lupus.
Genes and immunity. 18(3):111-117 [DOI] 10.1038/gene.2017.8. [PMID] 28490805.
2017
Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD-iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3.
Autoimmunity. 50(1):42-51 [DOI] 10.1080/08916934.2016.1272597. [PMID] 28166678.
2017
An update on lupus animal models.
Current opinion in rheumatology. 29(5):434-441 [DOI] 10.1097/BOR.0000000000000412. [PMID] 28537986.
2017
B cell contribution of the CD4+ T cell inflammatory phenotypes in systemic lupus erythematosus.
Autoimmunity. 50(1):37-41 [DOI] 10.1080/08916934.2017.1280028. [PMID] 28166683.
2017
B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.00362. [PMID] 28424695.
2017
Immunometabolism in systemic lupus erythematosus.
Nature reviews. Rheumatology. 13(5):280-290 [DOI] 10.1038/nrrheum.2017.43. [PMID] 28360423.
2017
The PBX1 lupus susceptibility gene regulates CD44 expression.
Molecular immunology. 85:148-154 [DOI] 10.1016/j.molimm.2017.02.016. [PMID] 28257976.
2016
Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus.
PloS one. 11(5) [DOI] 10.1371/journal.pone.0156583. [PMID] 27232337.
2016
Expansion of B-1a Cells with Germline Heavy Chain Sequence in Lupus Mice.
Frontiers in immunology. 7 [DOI] 10.3389/fimmu.2016.00108. [PMID] 27047495.
2016
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Journal of immunology (Baltimore, Md. : 1950). 196(1):80-90 [DOI] 10.4049/jimmunol.1501537. [PMID] 26608911.
2016
Immune Cell Metabolism in Systemic Lupus Erythematosus.
Current rheumatology reports. 18(11) [PMID] 27709413.
View on: PubMed
2016
Metabolic Factors that Contribute to Lupus Pathogenesis.
Critical reviews in immunology. 36(1):75-98 [DOI] 10.1615/CritRevImmunol.2016017164. [PMID] 27480903.
2016
Quercitrin ameliorates the development of systemic lupus erythematosus-like disease in a chronic graft-versus-host murine model.
American journal of physiology. Renal physiology. 311(1):F217-26 [DOI] 10.1152/ajprenal.00249.2015. [PMID] 26911849.
2016
Targeted approaches to induce immune tolerance for Pompe disease therapy.
Molecular therapy. Methods & clinical development. 3 [DOI] 10.1038/mtm.2015.53. [PMID] 26858964.
2016
The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950). 197(2):458-69 [DOI] 10.4049/jimmunol.1502283. [PMID] 27296664.
2015
BAFF blockade prevents anti-drug antibody formation in a mouse model of Pompe disease.
Clinical immunology (Orlando, Fla.). 158(2):140-7 [DOI] 10.1016/j.clim.2015.03.022. [PMID] 25842186.
2015
Contribution of B-1a cells to systemic lupus erythematosus in the NZM2410 mouse model.
Annals of the New York Academy of Sciences. 1362:215-23 [DOI] 10.1111/nyas.12607. [PMID] 25728381.
2015
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.
Genetics & epigenetics. 7:5-17 [DOI] 10.4137/GEG.S29696. [PMID] 26512207.
2015
Genetic and cellular dissection of the activation of AM14 rheumatoid factor B cells in a mouse model of lupus.
Journal of leukocyte biology. 98(2):209-21 [DOI] 10.1189/jlb.1A1214-576R. [PMID] 25957308.
2015
Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.
The Journal of clinical investigation. 125(7):2877-90 [DOI] 10.1172/JCI81059. [PMID] 26098211.
2015
Normalization of CD4+ T cell metabolism reverses lupus.
Science translational medicine. 7(274) [DOI] 10.1126/scitranslmed.aaa0835. [PMID] 25673763.
2015
Pillars Article: Polygenic Control of Susceptibility to Murine Systemic Lupus Erythematosus. Immunity. 1994. 1: 219-229.
Journal of immunology (Baltimore, Md. : 1950). 195(9):4047-57 [PMID] 26477047.
View on: PubMed
2015
Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(4):1505-15 [DOI] 10.1096/fj.14-263061. [PMID] 25550471.
2015
The murine Pbx1-d lupus susceptibility allele accelerates mesenchymal stem cell differentiation and impairs their immunosuppressive function.
Journal of immunology (Baltimore, Md. : 1950). 194(1):43-55 [PMID] 25416808.
View on: PubMed
2015
Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene Transfer.
Journal of innate immunity. 7(3):302-14 [DOI] 10.1159/000369273. [PMID] 25612611.
2014
Contributions of B cells to lupus pathogenesis.
Molecular immunology. 62(2):329-38 [DOI] 10.1016/j.molimm.2013.11.013. [PMID] 24332482.
2014
Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupus.
PloS one. 9(8) [DOI] 10.1371/journal.pone.0102151. [PMID] 25093822.
2014
Immune tolerance induction to factor IX through B cell gene transfer: TLR9 signaling delineates between tolerogenic and immunogenic B cells.
Molecular therapy : the journal of the American Society of Gene Therapy. 22(6):1139-1150 [DOI] 10.1038/mt.2014.43. [PMID] 24609143.
2014
Induced murine models of systemic lupus erythematosus.
Methods in molecular biology (Clifton, N.J.). 1134:103-30 [DOI] 10.1007/978-1-4939-0326-9_9. [PMID] 24497358.
2014
The Combination of Metformin and 2-Deoxy-D-Glucose Normalizes Cd4 T Cell Metabolism and Functions, and Reverse Disease in Murine Models of Lupus.
Arthritis & Rheumatology. 66(10, SI)
2013
A Short Murine Lupus-Susceptibility Sle2C1Rec1Sublocus Functions as Both Contributor and Modifier of Autoimmune Disease in Cd95 Deficiency
Journal of Immunology. 190
2013
Characterizing the Role of the Granulocyte Colony Stimulating Factor Pathway in a Mouse Model of Systemic Lupus Erythematosus
Arthritis and Rheumatism. 65:S238-S239
2013
Contribution of Marginal Zone B Cells To Autoimmunity in the B6.Sle1.Sle2.Sle3 Lupus Prone Mouse.
Arthritis and Rheumatism. 65:S245-S246
2013
Regulation of Aberrant Cd4 T Cell Activation By Suppressor of Cytokine Signaling-1 (Socs1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Arthritis and Rheumatism. 65:S1163-S1164
2013
The combination of two Sle2 lupus-susceptibility loci and Cdkn2c deficiency leads to T-cell-mediated pathology in B6.Fas(lpr) mice.
Genes and immunity. 14(6):373-9 [DOI] 10.1038/gene.2013.28. [PMID] 23698709.
2013
The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice.
Blood. 121(11):1986-94 [DOI] 10.1182/blood-2012-05-433755. [PMID] 23315165.
2013
The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus.
Arthritis research & therapy. 15(2) [DOI] 10.1186/ar4208. [PMID] 23566364.
2012
Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice.
Journal of immunology (Baltimore, Md. : 1950). 188(9):4568-80 [DOI] 10.4049/jimmunol.1102154. [PMID] 22467656.
2012
Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model.
Journal of immunology (Baltimore, Md. : 1950). 188
2012
Animal models of molecular pathology systemic lupus erythematosus.
Progress in molecular biology and translational science. 105:321-70 [DOI] 10.1016/B978-0-12-394596-9.00010-X. [PMID] 22137436.
2012
Cyclin-dependent kinase inhibitor Cdkn2c deficiency promotes B1a cell expansion and autoimmunity in a mouse model of lupus.
Journal of immunology (Baltimore, Md. : 1950). 188
2012
Genetic variation at a Yin-Yang 1 response site regulates the transcription of cyclin-dependent kinase inhibitor p18INK4C transcript in lupus-prone mice.
Journal of immunology (Baltimore, Md. : 1950). 188(10):4992-5002 [DOI] 10.4049/jimmunol.1101992. [PMID] 22504641.
2012
Mapping lupus susceptibility genes in the NZM2410 mouse model.
Advances in immunology. 115:113-39 [DOI] 10.1016/B978-0-12-394299-9.00004-7. [PMID] 22608257.
2012
Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.
Journal of immunology (Baltimore, Md. : 1950). 189(2):793-803 [DOI] 10.4049/jimmunol.1200411. [PMID] 22711888.
2012
Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.
Journal of immunology (Baltimore, Md. : 1950). 188(2):604-14 [DOI] 10.4049/jimmunol.1002362. [PMID] 22180614.
2012
Pre-B Cell Leukemia Homeobox 1Is a Novel Susceptibility Gene That Regulate T Cell Functions.
Journal of Immunology. 188
2012
Regulation of T Cell Metabolism and Autoimmunity By the Orphan Nuclear Receptor Err Gamma
Journal of Immunology. 188
2012
The Lupus-Susceptibility Sle2C1 Sublocus Regulates T Cell Expansion Through Several Mechanisms
Journal of Immunology. 188
2012
The SLE-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator.
Genes and immunity. 13(8):653-7 [DOI] 10.1038/gene.2012.43. [PMID] 22992721.
2011
A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells.
Journal of immunology (Baltimore, Md. : 1950). 186(7):4130-9 [DOI] 10.4049/jimmunol.1003512. [PMID] 21335485.
2011
A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis and Rheumatism. 63
2011
A novel isoform of the Ly108 gene ameliorates murine lupus.
The Journal of experimental medicine. 208(4):811-22 [DOI] 10.1084/jem.20101653. [PMID] 21422172.
2011
Activation-induced cytidine deaminase catalytic domain as a target to eliminate pathogenic autoantibodies.
Arthritis and rheumatism. 63(7):1776-8 [DOI] 10.1002/art.30256. [PMID] 21305518.
2011
Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice.
BMC immunology. 12 [DOI] 10.1186/1471-2172-12-7. [PMID] 21251257.
2011
Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1.
Journal of immunology (Baltimore, Md. : 1950). 186(12):6673-82 [DOI] 10.4049/jimmunol.1002544. [PMID] 21543644.
2011
Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.
Arthritis research & therapy. 13(3) [DOI] 10.1186/ar3387. [PMID] 21708033.
2011
Lupus at the molecular level.
Protein & cell. 2(12):941-3 [DOI] 10.1007/s13238-011-1123-1. [PMID] 22183810.
2011
Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes.
Genes and immunity. 12(3):199-207 [DOI] 10.1038/gene.2010.69. [PMID] 21270826.
2011
Murine models of systemic lupus erythematosus.
Journal of biomedicine & biotechnology. 2011 [DOI] 10.1155/2011/271694. [PMID] 21403825.
2011
The current concept of T (h) 17 cells and their expanding role in systemic lupus erythematosus.
Arthritis. 2011 [DOI] 10.1155/2011/810649. [PMID] 22164330.
2011
The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in fas-deficient mice.
Arthritis and rheumatism. 63(3):764-74 [DOI] 10.1002/art.30146. [PMID] 21360506.
2011
The Role of Pbx1 in T Cells
Protein and Cell. 2(6):946-949 [DOI] 10.1007/s13238-011-1136. [PMID] 23100456.
2011
The role of Pbx1 in T cells.
Protein & cell. 2(12):946-9 [DOI] 10.1007/s13238-011-1136-9. [PMID] 22231354.
2010
An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation.
Journal of immunology (Baltimore, Md. : 1950). 185(4):2331-9 [DOI] 10.4049/jimmunol.1000783. [PMID] 20660348.
2010
Constitutive overexpression of BAFF in autoimmune-resistant mice drives only some aspects of systemic lupus erythematosus-like autoimmunity.
Arthritis and rheumatism. 62(8):2432-42 [DOI] 10.1002/art.27502. [PMID] 20506216.
2010
Expression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis.
Human molecular genetics. 19(22):4497-514 [DOI] 10.1093/hmg/ddq381. [PMID] 20826447.
2010
Genetics of SLE: evidence from mouse models.
Nature reviews. Rheumatology. 6(6):348-57 [DOI] 10.1038/nrrheum.2010.63. [PMID] 20440287.
2010
Genetics of systemic lupus erythematosus: contributions of mouse models in the era of human genome-wide association studies.
Discovery medicine. 10(50):71-8 [PMID] 20670601.
View on: PubMed
2010
Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.
Genes and immunity. 11(7):542-53 [DOI] 10.1038/gene.2010.23. [PMID] 20445563.
2010
NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.
Journal of immunology (Baltimore, Md. : 1950). 185(9):5247-58 [DOI] 10.4049/jimmunol.1001472. [PMID] 20881184.
2009
Association between CARD15/NOD2 gene polymorphisms and paratuberculosis infection in cattle.
Veterinary microbiology. 134(3-4):346-52 [DOI] 10.1016/j.vetmic.2008.09.052. [PMID] 18926647.
2009
Candidate gene polymorphisms (BoIFNG, TLR4, SLC11A1) as risk factors for paratuberculosis infection in cattle.
Preventive veterinary medicine. 91(2-4):189-96 [DOI] 10.1016/j.prevetmed.2009.05.020. [PMID] 19525022.
2009
Defective Retinoic Acid Expansion of Foxp3+Regulatory T Cells in Lupus
Clinical Immunology. 131 [DOI] 10.1016/j.clim.2009.03.449.
2008
Defective B-cell response to T-dependent immunization in lupus-prone mice.
European journal of immunology. 38(11):3028-40 [DOI] 10.1002/eji.200838417. [PMID] 18924209.
2008
Direct B cell stimulation by dendritic cells in a mouse model of lupus.
Arthritis and rheumatism. 58(6):1741-50 [DOI] 10.1002/art.23515. [PMID] 18512810.
2008
Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus.
Laboratory investigation; a journal of technical methods and pathology. 88(9):1008-20 [DOI] 10.1038/labinvest.2008.62. [PMID] 18607347.
2008
The publishing game: reflections of an editorial team.
Laboratory investigation; a journal of technical methods and pathology. 88(12):1258-63 [DOI] 10.1038/labinvest.2008.113. [PMID] 19020521.
2007
Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice.
Toxicological sciences : an official journal of the Society of Toxicology. 99(1):141-52 [PMID] 17578864.
View on: PubMed
2007
Augmentation of NZB autoimmune phenotypes by the Sle1c murine lupus susceptibility interval.
Journal of immunology (Baltimore, Md. : 1950). 178(7):4667-75 [PMID] 17372026.
View on: PubMed
2007
Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production.
Genes and immunity. 8(7):604-12 [PMID] 17713556.
View on: PubMed
2007
Genetics of autoreactive B cells.
Frontiers in bioscience : a journal and virtual library. 12:1707-21 [PMID] 17127416.
View on: PubMed
2007
Genetics of human lupus nephritis.
Seminars in nephrology. 27(1):2-11 [PMID] 17336684.
View on: PubMed
2007
IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions.
Journal of immunology (Baltimore, Md. : 1950). 178(1):271-9 [PMID] 17182564.
View on: PubMed
2007
Lupus resistance is associated with marginal zone abnormalities in an NZM murine model.
Laboratory investigation; a journal of technical methods and pathology. 87(1):14-28 [PMID] 17170739.
View on: PubMed
2007
Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms.
Journal of immunology (Baltimore, Md. : 1950). 179(11):7439-47 [PMID] 18025188.
View on: PubMed
2006
IL-10 regulation of lupus in the NZM2410 murine model.
Laboratory investigation; a journal of technical methods and pathology. 86(11):1136-48 [PMID] 16924244.
View on: PubMed
2006
Role of B-1a cells in autoimmunity.
Autoimmunity reviews. 5(6):403-8 [PMID] 16890894.
View on: PubMed
2006
STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus.
Clinical immunology (Orlando, Fla.). 120(2):189-98 [PMID] 16713741.
View on: PubMed
2005
Alterations of renal phenotype and gene expression profiles due to protein overload in NOD-related mouse strains.
BMC nephrology. 6 [PMID] 16371158.
View on: PubMed
2005
BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus.
Arthritis and rheumatism. 52(7):2080-91 [PMID] 15986357.
View on: PubMed
2005
Deficiency of type I interferon contributes to Sle2-associated component lupus phenotypes.
Arthritis and rheumatism. 52(10):3063-72 [PMID] 16200585.
View on: PubMed
2005
Genetic determination of T cell help in loss of tolerance to nuclear antigens.
Journal of immunology (Baltimore, Md. : 1950). 174(12):7692-702 [PMID] 15944270.
View on: PubMed
2005
Genetic dissection of systemic lupus erythematosus pathogenesis: partial functional complementation between Sle1 and Sle3/5 demonstrates requirement for intracellular coexpression for full phenotypic expression of lupus.
Journal of immunology (Baltimore, Md. : 1950). 175(2):1337-45 [PMID] 16002739.
View on: PubMed
2005
Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci.
Journal of immunology (Baltimore, Md. : 1950). 175(2):936-43 [PMID] 16002692.
View on: PubMed
2005
Genetics of T cell defects in lupus.
Cellular & molecular immunology. 2(6):403-9 [PMID] 16426489.
View on: PubMed
2005
Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.
Journal of immunology (Baltimore, Md. : 1950). 175(7):4561-5 [PMID] 16177100.
View on: PubMed
2005
Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.
Journal of immunology (Baltimore, Md. : 1950). 175(2):1080-9 [PMID] 16002709.
View on: PubMed
2005
Treatment with a laminin-derived peptide suppresses lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950). 175(8):5516-23 [PMID] 16210660.
View on: PubMed
2004
Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse.
Clinical immunology (Orlando, Fla.). 110(2):124-33 [PMID] 15003809.
View on: PubMed
2004
Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus.
Immunity. 21(6):769-80 [PMID] 15589166.
View on: PubMed
2004
Dichotomous effects of complete versus partial class II major histocompatibility complex deficiency on circulating autoantibody levels in autoimmune-prone mice.
Arthritis and rheumatism. 50(7):2227-39 [PMID] 15248222.
View on: PubMed
2004
Genetic dissection of lupus pathogenesis: Sle3/5 impacts IgH CDR3 sequences, somatic mutations, and receptor editing.
Journal of immunology (Baltimore, Md. : 1950). 173(12):7368-76 [PMID] 15585861.
View on: PubMed
2004
Mechanisms of peritoneal B-1a cells accumulation induced by murine lupus susceptibility locus Sle2.
Journal of immunology (Baltimore, Md. : 1950). 173(10):6050-8 [PMID] 15528340.
View on: PubMed
2004
Mouse models of human autoimmune diseases: essential tools that require the proper controls.
PLoS biology. 2(8) [PMID] 15314657.
View on: PubMed
2004
Production of heterologous protein by Methylobacterium extorquens in high cell density fermentation.
FEMS microbiology letters. 231(2):197-204 [PMID] 14987765.
View on: PubMed
2004
Quantitative trait loci in Chromosomes 3, 8, and 9 regulate antibody production against Salmonella flagellar antigens in the mouse.
Mammalian genome : official journal of the International Mammalian Genome Society. 15(8):630-6 [PMID] 15457342.
View on: PubMed
2004
The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression.
Journal of immunology (Baltimore, Md. : 1950). 172(5):2785-94 [PMID] 14978078.
View on: PubMed
2004
Untying the gordian knot of autoimmunity and b cell lineage lymphomas.
Autoimmunity reviews. 3 Suppl 1:S10-1 [PMID] 15309767.
View on: PubMed
2003
A genetic lesion that arrests plasma cell homing to the bone marrow.
Proceedings of the National Academy of Sciences of the United States of America. 100(22):12905-10 [PMID] 14555759.
View on: PubMed
2003
Characteristics of hydrocephalus expression in the LEW/Jms rat strain with inherited disease.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 19(1):11-8 [PMID] 12541080.
View on: PubMed
2003
Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice.
Journal of immunology (Baltimore, Md. : 1950). 170(11):5429-37 [PMID] 12759418.
View on: PubMed
2003
Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus.
Genes and immunity. 4(8):575-85 [PMID] 14647198.
View on: PubMed
2003
Hormonal and developmental regulation of the mouse aldose reductase-like gene akr1b7 expression in Leydig cells.
Journal of molecular endocrinology. 31(1):71-81 [PMID] 12914526.
View on: PubMed
2002
A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950). 169(3):1587-92 [PMID] 12133988.
View on: PubMed
2002
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
Nature. 416(6880):542-5 [PMID] 11932747.
View on: PubMed
2002
Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells.
Journal of immunology (Baltimore, Md. : 1950). 169(7):4025-32 [PMID] 12244205.
View on: PubMed
2002
Genetics of autoimmune diseases in humans and in animal models.
Current opinion in immunology. 14(6):803-11 [PMID] 12413533.
View on: PubMed
2002
The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.
Journal of immunology (Baltimore, Md. : 1950). 169(5):2694-700 [PMID] 12193743.
View on: PubMed
2001
Chromosomal linkage associated with disease severity in the hydrocephalic H-Tx rat.
Behavior genetics. 31(1):101-11 [PMID] 11529267.
View on: PubMed
2001
Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein.
Immunity. 15(5):775-85 [PMID] 11728339.
View on: PubMed
2001
Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat.
Mammalian genome : official journal of the International Mammalian Genome Society. 12(1):22-6 [PMID] 11178739.
View on: PubMed
2001
Mouse seminal vesicle secretory protein of 99 amino acids (MSVSP99): characterization and hormonal and developmental regulation.
Journal of andrology. 22(4):549-57 [PMID] 11451351.
View on: PubMed
2001
The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes.
Proceedings of the National Academy of Sciences of the United States of America. 98(4):1787-92 [PMID] 11172029.
View on: PubMed
2000
Down-regulation of AP1 activities after polarization of vas deferens epithelial cells correlates with androgen-induced gene expression.
The Journal of steroid biochemistry and molecular biology. 72(3-4):103-13 [PMID] 10775801.
View on: PubMed
2000
Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.
Proceedings of the National Academy of Sciences of the United States of America. 97(12):6670-5 [PMID] 10841565.
View on: PubMed
2000
Lessons from the NZM2410 model and related strains.
International reviews of immunology. 19(4-5):423-46 [PMID] 11016426.
View on: PubMed
2000
Reduced susceptibility of nonobese diabetic mice to TNF-alpha and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Journal of immunology (Baltimore, Md. : 1950). 165(11):6559-67 [PMID] 11086099.
View on: PubMed
2000
The expression of inherited hydrocephalus in H-Tx rats.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 16(9):578-84 [PMID] 11048632.
View on: PubMed
2000
The lipocalin sperm coating lizard epididymal secretory protein family: mRNA structural analysis and sequential expression during the annual cycle of the lizard, Lacerta vivipara.
Journal of molecular endocrinology. 24(1):127-33 [PMID] 10657004.
View on: PubMed
1999
Breeding characteristics and genetic analysis of the H-Tx rat strain.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery … [et al] = Zeitschrift fur Kinderchirurgie. 9 Suppl 1:42-3 [PMID] 10661794.
View on: PubMed
1999
Epistatic modifiers of autoimmunity in a murine model of lupus nephritis.
Immunity. 11(2):131-9 [PMID] 10485648.
View on: PubMed
1999
Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies.
The Journal of clinical investigation. 103(12):1685-95 [PMID] 10377175.
View on: PubMed
1999
Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells.
Journal of immunology (Baltimore, Md. : 1950). 162(4):2415-21 [PMID] 9973523.
View on: PubMed
1999
Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death.
Journal of immunology (Baltimore, Md. : 1950). 162(11):6492-502 [PMID] 10352264.
View on: PubMed
1999
Genetic dissection of systemic lupus erythematosus.
Current opinion in immunology. 11(6):701-7 [PMID] 10631557.
View on: PubMed
1999
Multiplex inheritance of component phenotypes in a murine model of lupus.
Mammalian genome : official journal of the International Mammalian Genome Society. 10(2):176-81 [PMID] 9922399.
View on: PubMed
1999
Structural and functional analysis of the promoter of a mouse gene encoding an androgen-regulated protein (MSVSP99).
Journal of molecular endocrinology. 23(3):287-98 [PMID] 10601974.
View on: PubMed
1998
Accumulation of splenic B1a cells with potent antigen-presenting capability in NZM2410 lupus-prone mice.
Arthritis and rheumatism. 41(9):1652-62 [PMID] 9751099.
View on: PubMed
1998
Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background.
Proceedings of the National Academy of Sciences of the United States of America. 95(24):14517-22 [PMID] 9826732.
View on: PubMed
1998
Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes.
The Journal of clinical investigation. 101(6):1362-72 [PMID] 9502778.
View on: PubMed
1998
Susceptibility to lupus nephritis in the NZB/W model system.
Current opinion in immunology. 10(6):718-25 [PMID] 9914223.
View on: PubMed
1997
Androgen induction of the SVS family related protein MSVSP99: identification of a functional androgen response element.
Molecular and cellular endocrinology. 136(1):91-9 [PMID] 9510071.
View on: PubMed
1997
Functional dissection of systemic lupus erythematosus using congenic mouse strains.
Journal of immunology (Baltimore, Md. : 1950). 158(12):6019-28 [PMID] 9190957.
View on: PubMed
1997
Genetic dissection of lupus nephritis in murine models of SLE.
Journal of clinical immunology. 17(4):272-81 [PMID] 9258766.
View on: PubMed
1997
Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity.
Journal of immunology (Baltimore, Md. : 1950). 159(1):454-65 [PMID] 9200486.
View on: PubMed
1997
Speed congenics: a classic technique in the fast lane (relatively speaking).
Immunology today. 18(10):472-7 [PMID] 9357138.
View on: PubMed
1997
The androgen-dependent mouse seminal vesicle secretory protein of 99 amino acids (MSVSP99): regulation of the mRNA and preliminary characterization of the promoter.
The Journal of steroid biochemistry and molecular biology. 61(1-2):87-95 [PMID] 9328214.
View on: PubMed
1997
Ubiquitous transcription factors NF1 and Sp1 are involved in the androgen activation of the mouse vas deferens protein promoter.
Molecular and cellular endocrinology. 132(1-2):13-23 [PMID] 9324042.
View on: PubMed
1996
Backcross analysis of genes linked to autoantibody production in New Zealand White mice.
Journal of immunology (Baltimore, Md. : 1950). 157(6):2719-27 [PMID] 8805679.
View on: PubMed
1996
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain.
Mammalian genome : official journal of the International Mammalian Genome Society. 7(5):335-9 [PMID] 8661718.
View on: PubMed
1994
Polygenic control of susceptibility to murine systemic lupus erythematosus.
Immunity. 1(3):219-29 [PMID] 7889410.
View on: PubMed
1993
LESP, an androgen-regulated lizard epididymal secretory protein family identified as a new member of the lipocalin superfamily.
The Journal of biological chemistry. 268(14):10274-81 [PMID] 8486691.
View on: PubMed

Grants

May 2021 ACTIVE
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
May 2021 ACTIVE
Immunomodulation Approaches to Improve Safety And Efficacy of Gene Therapy Treatment in Friedreichs Ataxia
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2020 ACTIVE
Determinants of follicular helper T cell expansion in lupus
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2020 ACTIVE
Development of a novel gene therapy for lupus
Role: Co-Investigator
Funding: SAREPTA THERAPEUTICS
Aug 2019 ACTIVE
Role of CXCR2-mediated cell trafficking in pulmonary vascular remodeling
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jan 2019 ACTIVE
Gut dysbiosis and tryptophan metabolism in lupus
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2018 ACTIVE
Characterization of SLE-susceptibility loci on mouse chromosome 1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2018 – Feb 2021
Targeting immunometabolism and co-stimulation in combination therapies in lupus
Role: Principal Investigator
Funding: LUPUS RESEARCH ALLIANCE
Jun 2017 – May 2019
OR-DRPD-ROF2017: Immune evasion mechanisms during oral infection by an oncogenic herpesvirus
Role: Co-Investigator
Funding: UF DSR OPPORTUNITY FUND
May 2017 – Aug 2017
Metabolic Functions of the Lupus Susceptibility Gene Pbx1: 2017 Gina M Finzi memorial Student Summer Fellowship
Role: Principal Investigator
Funding: LUPUS FOU OF AMERICA
Dec 2016 ACTIVE
Targeting follicular helper CD4 T cells in SLE
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2016 – Feb 2020
Targeting follicular helper CD4 T cells in SLE
Role: Principal Investigator
Funding: LUPUS RESEARCH ALLIANCE
Jun 2016 – May 2018
Second generation acetyl-CoA carboxylase (ACC) inhibitors with an immunoregulatory function
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
May 2016 – Apr 2019
Genetic regulation of mesenchymal stem cell defects in lupus
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Jan 2016 – Dec 2018
Gut dysbiosis induces iupus
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2015 ACTIVE
REnal TrAIning & reteNtion (RETAIN) Program
Role: Other
Funding: NATL INST OF HLTH NIDDK
May 2015 – May 2017
Therapeutic Targeting of immune metabolism
Role: Principal Investigator
Funding: UF DIV OF SPONSORED RESEARCH
Jan 2015 – Jan 2017
The Protective Effect of Prolostin C for the Treatment of Lupus
Role: Project Manager
Funding: GRIFOLS WORLDWIDE OPERATIONS LTD
Feb 2014 – Apr 2017
High through-put screening to repurpose drugs for lupus therapeutics proposal 2
Role: Principal Investigator
Funding: LUPUS RESEARCH ALLIANCE
May 2013 – Jun 2018
Characterization of SLE-susceptibility loci on mouse chromosome 1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Feb 2013 – Jan 2016
CD4 T Cell Metabolism in SLE: Characterization and Target Identification
Role: Principal Investigator
Funding: LUPUS RESEARCH ALLIANCE
Oct 2009 ACTIVE
Whisenant Professorship UFF Endowment for Cancer Research
Role: Principal Investigator
Funding: UF FOU

Patents

Published July 2009
Materials and Methods For The Detection, Prevention and Treatment of Autoimmune Disease
#US-2010-0178652-A1

Teaching Profile

Courses Taught
2008-2012,2014-2021,2016-2021,2018-2021,2020-2021
GMS6337 B Cell Development in Health and Disease
2006-2008,2011-2015,2013-2021
GMS6921 Immunology/Microbiology Journal Colloquy
2018
MCB7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2018
VME7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2009,2016-2021,2021
GMS5905 Special Topics in Biomedical Sciences
2014-2016,2021
GMS6140 Principles of Immunology
2011
GMS7191 Research Conference
2009
IDH4917 Undergrad Research
2007
GMS6011 Mouse Genetics

Contact Details

Phones:
Business:
(352) 392-3790
Emails: