M Zehra Ordulu Sahin,
CLIN AST PROF
Department:
MD-PATHOLOGY-GENERAL
Business Phone:
(352) 627-9240
Business Email:
mordulusahin@ufl.edu
About M Zehra Ordulu Sahin
Dr Ordulu’s academic interests include: 1) Studying clinicopathological characteristics of gynecological tract tumors 2) Integrating different layers of molecular “omics” data into the practice of gynecologic pathology. With a background combining a strong training in anatomic pathology and a long-standing experience in molecular genetics, her long-term goals are to continue to integrate the two fields to transform the gynecologic pathology diagnostics into the era of precision medicine.
Additional Positions:
Gynecologic Pathology Unit Director
2021 – Current
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Accomplishments
Gynecologic Oncology Fellowship Teaching Award
2020
·
Massachusetts General Hospital
Featured Women Researcher
2014
·
Brigham and Women's Hospital
Research Excellence Award
2014
·
Brigham and Women's Hospital
Charles J. Epstein Trainee Award for Excellence in Human Genetics Research – Finalist
2012
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American Society of Human Genetics
Featured Women Researcher
2012
·
Brigham and Women's Hospital
Research Excellence Award
2012
·
Brigham and Women's Hospital
Teaching Profile
Courses Taught
2022
DEN6350 General Pathology
2024
BMS6632 Endo and Reproduction
Board Certifications
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Combined Anatomic Pathology & Clinical Pathology Certification (AP/CP)American Board of Pathology
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ECFMGEducational Commission For Foreign Medical Graduates
-
Molecular PathologyAmerican Board of Pathology
Clinical Profile
Areas of Interest
- Genetics
- Gynecological cancer
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-3218-1075
Publications
2023
Commentary: towards precision medicine for uterine leiomyomas based on molecular subgroups
Human Molecular Genetics.
32(7):1061-1062
[DOI] 10.1093/hmg/ddac277.
2023
Extrauterine epithelioid trophoblastic tumour and its somatic carcinoma mimics: short tandem repeat genotyping meets the diagnostic challenges.
Histopathology.
84(2):325-335
[DOI] 10.1111/his.15054.
[PMID] 37743102.
2023
Midline brain hamartomatous lesions in fibrodysplasia ossificans progressiva with ACVR1 mutations.
Neuropathology : official journal of the Japanese Society of Neuropathology.
43(4):333-339
[DOI] 10.1111/neup.12892.
[PMID] 36642816.
2023
Sebaceous differentiation can occur in vulvar adenoid cystic carcinoma
International Journal of Gynecologic Cancer.
33(11):1830-1832
[DOI] 10.1136/ijgc-2023-004323.
2023
Sensitivity to ALK-Directed Therapy in Osteosarcoma With an Acquired ALK Rearrangement
JCO Precision Oncology.
(7)
[DOI] 10.1200/po.23.00287.
2023
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
Cell.
186(11):2361-2379.e25
[DOI] 10.1016/j.cell.2023.04.026.
[PMID] 37192619.
2023
Update on Ovarian Sex Cord-Stromal Tumors.
Clinics in laboratory medicine.
43(2):245-274
[DOI] 10.1016/j.cll.2023.03.001.
[PMID] 37169445.
2022
Molecular Detection of Oncogenic Gene Rearrangements.
Clinics in laboratory medicine.
42(3):435-449
[DOI] 10.1016/j.cll.2022.05.002.
[PMID] 36150822.
2022
Morphologic and Molecular Heterogeneity of Cervical Neuroendocrine Neoplasia: A Report of 14 Cases.
The American journal of surgical pathology.
46(12):1670-1681
[DOI] 10.1097/PAS.0000000000001943.
2022
Update on Ovarian Sex Cord-Stromal Tumors.
Surgical pathology clinics.
15(2):235-258
[DOI] 10.1016/j.path.2022.02.004.
[PMID] 35715160.
2021
Case 9-2021: A 16-Year-Old Boy with Headache, Abdominal Pain, and Hypertension.
The New England journal of medicine.
384(12):1145-1155
[DOI] 10.1056/NEJMcpc2027094.
[PMID] 33761211.
2021
Deranged chromatin drives uterine fibroid tumours.
Nature.
596(7872):349-351
[DOI] 10.1038/d41586-021-02005-8.
[PMID] 34349270.
2021
Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
[DOI] 10.1038/s41379-021-00821-x.
2021
Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab.
Oncotarget.
12(21):2131-2146
[DOI] 10.18632/oncotarget.28086.
[PMID] 34676046.
2021
Innovating Evaluation and Treatment of Intrapartum Fevers: Where Do We Go from Here?
American journal of perinatology.
[DOI] 10.1055/s-0041-1727279.
[PMID] 33878764.
2021
Locally Recurrent Secretory Carcinoma of the Breast with NTRK3 Gene Fusion.
The oncologist.
[DOI] 10.1002/onco.13880.
[PMID] 34176200.
2021
Low-grade Endometrial Stromal Sarcoma With Sex Cord-like Differentiation and PHF1-JAZF1 Fusion With Deletions: A Diagnostic Pitfall of JAZF1 FISH.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.
[DOI] 10.1097/PGP.0000000000000795.
[PMID] 34074959.
2021
Molecular Pathology of Ovarian Epithelial Neoplasms: Predictive, Prognostic, and Emerging Biomarkers.
Surgical pathology clinics.
14(3):415-428
[DOI] 10.1016/j.path.2021.05.006.
[PMID] 34373093.
2021
Reproducibility of scoring criteria for HER2 immunohistochemistry in endometrial serous carcinoma: a multi-institutional interobserver agreement study.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
34(6):1194-1202
[DOI] 10.1038/s41379-021-00746-5.
2021
Sertoli-Leydig Cell Tumors of the Ovary With Follicular Differentiation Often Resembling Juvenile Granulosa Cell Tumor: A Report of 38 Cases Including Comments on Sex Cord-Stromal Tumors of Mixed Forms (So-called Gynandroblastoma).
The American journal of surgical pathology.
45(1):59-67
[DOI] 10.1097/PAS.0000000000001544.
[PMID] 32815828.
2021
Uterine PEComas: correlation between melanocytic marker expression and TSC alterations/TFE3 fusions.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
[DOI] 10.1038/s41379-021-00855-1.
[PMID] 34131293.
2020
Molecular and clinicopathologic characterization of intravenous leiomyomatosis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
33(9):1844-1860
[DOI] 10.1038/s41379-020-0546-8.
[PMID] 32341498.
2020
Pediatric liver transplant following near catastrophic head bleed: Lessons learned.
Pediatric transplantation.
24(2)
[DOI] 10.1111/petr.13646.
[PMID] 31960553.
2018
Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata.
Cancer genetics.
222-223:1-8
[DOI] 10.1016/j.cancergen.2018.01.001.
[PMID] 29666002.
2018
Phenotypic interpretation of complex chromosomal rearrangements informed by nucleotide-level resolution and structural organization of chromatin.
European journal of human genetics : EJHG.
26(3):374-381
[DOI] 10.1038/s41431-017-0068-0.
[PMID] 29321672.
2017
Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements.
American journal of human genetics.
101(2):206-217
[DOI] 10.1016/j.ajhg.2017.06.011.
[PMID] 28735859.
2017
Implication of LRRC4C and DPP6 in neurodevelopmental disorders.
American journal of medical genetics. Part A.
173(2):395-406
[DOI] 10.1002/ajmg.a.38021.
[PMID] 27759917.
2017
The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies.
Nature genetics.
49(1):36-45
[DOI] 10.1038/ng.3720.
[PMID] 27841880.
2016
Fibroids: Genotype and Phenotype.
Clinical obstetrics and gynecology.
59(1):25-9
[DOI] 10.1097/GRF.0000000000000177.
[PMID] 26710305.
2016
Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
29(5):500-10
[DOI] 10.1038/modpathol.2016.36.
[PMID] 26892441.
2016
Structural Chromosomal Rearrangements Require Nucleotide-Level Resolution: Lessons from Next-Generation Sequencing in Prenatal Diagnosis.
American journal of human genetics.
99(5):1015-1033
[DOI] 10.1016/j.ajhg.2016.08.022.
[PMID] 27745839.
2015
Autografted Electrical Burn Complicated by Cutaneous Chromoblastomycosis.
Eplasty.
15
[PMID] 26557947.
2015
Prenatal diagnosis of chromothripsis, with nine breaks characterized by karyotyping, FISH, microarray and whole-genome sequencing.
Prenatal diagnosis.
35(3):299-301
[DOI] 10.1002/pd.4456.
[PMID] 25043231.
2014
Describing sequencing results of structural chromosome rearrangements with a suggested next-generation cytogenetic nomenclature.
American journal of human genetics.
94(5):695-709
[DOI] 10.1016/j.ajhg.2014.03.020.
[PMID] 24746958.
2013
Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate.
Human genetics.
132(5):537-52
[DOI] 10.1007/s00439-013-1263-x.
[PMID] 23354975.
2012
Clinical diagnosis by whole-genome sequencing of a prenatal sample.
The New England journal of medicine.
367(23):2226-32
[DOI] 10.1056/NEJMoa1208594.
[PMID] 23215558.
2012
The selective expression of ret finger protein in endometrial cancer: can RFP be a marker of serous carcinomas?
Turk patoloji dergisi.
28(3):213-9
[DOI] 10.5146/tjpath.2012.01127.
[PMID] 23011823.
2010
Disseminated peritoneal leiomyomatosis after laparoscopic supracervical hysterectomy with characteristic molecular cytogenetic findings of uterine leiomyoma.
Genes, chromosomes & cancer.
49(12):1152-60
[DOI] 10.1002/gcc.20824.
[PMID] 20842731.
Grants
Apr 2023
– Mar 2024
Guided Therapeutics Clinical Trial
Role: Principal Investigator
Funding: GUIDED THERAPEUTICS
Education
Molecular Genetic Pathology Fellowship
2020-2021
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Brigham and Women's Hospital, Harvard Medical School
Surgical Pathology Fellowship (Ob/Gyn)
2019-2020
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Massachusetts General Hospital
AP/CP Residency
2015-2019
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Massachusetts General Hosptial
Postdoctoral Research Fellowship
2011-2015
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Brigham and Women's Hospital
MD
2005-2011
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Hacettepe University Faculty of Medicine, Turkey
Contact Details
Phones:
- Business:
- (352) 627-9240
Emails:
- Business:
- mordulusahin@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100275
GAINESVILLE FL 32610