Daniel J Perry

Daniel J Perry,

Assistant Research Scientist

Department: MD-PATHOLOGY-GENERAL
Business Phone: (352) 294-8732
Business Email: perryd@pathology.ufl.edu

About Daniel J Perry

I am currently a Research Assistant Scientist and Co-Director of the Immune Monitoring Core at the University of Florida Diabetes Institute (UFDI). My research objectives are to elucidate the functional impact of the genetic risk variants in type 1 diabetes (T1D) pathogenesis, as well as to discover novel T1D biomarkers through a comprehensive immunophenotyping and genotyping effort.

Research Profile

In conjunction with complete blood counts, we developed a pipeline to efficiently process and assess over 150 immune cell subset frequencies and absolute counts per sample, which was the impetus for our Immune Monitoring Core. Our UFDI cohort has now grow to over 1000 subjects with complete comprehensive immunophenotypes, genotypes from a 975K SNP array, imputed 4-digit Class I and II HLA, as well as several other clinically relevant data. We have teamed with data scientists and biostatisticians to assist with the specialized statistical methods with the aim to link specific types of genetic risks and altered immune cell frequencies to T1D etiologies. In doing so, we are also establishing circulating immune cell reference ranges that will benefit the entire research community.

Open Researcher and Contributor ID (ORCID)

0000-0002-0607-2238

Areas of Interest
  • Autoimmune Disease
  • Genetics
  • Immune Tolerance
  • Immunology of Type 1 diabetes

Publications

2021
CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII.
Molecular therapy : the journal of the American Society of Gene Therapy. 29(9):2660-2676 [DOI] 10.1016/j.ymthe.2021.04.034. [PMID] 33940160.
2021
De-coding genetic risk variants in type 1 diabetes.
Immunology and cell biology. 99(5):496-508 [DOI] 10.1111/imcb.12438. [PMID] 33483996.
2021
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.
Diabetes. 70(4):944-954 [DOI] 10.2337/db20-0995. [PMID] 33441381.
2021
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.
Diabetes. 70(4):932-943 [DOI] 10.2337/db20-0937. [PMID] 33419759.
2021
Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation.
Journal of immunology (Baltimore, Md. : 1950). 207(3):849-859 [DOI] 10.4049/jimmunol.2000708. [PMID] 34301848.
2021
TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes.
Cell. 184(3):827-839.e14 [DOI] 10.1016/j.cell.2020.11.035. [PMID] 33545036.
2020
A Novel Mutation in Insulin-Like Growth Factor 1 Receptor (c.641-2A>G) Is Associated with Impaired Growth, Hypoglycemia, and Modified Immune Phenotypes.
Hormone research in paediatrics. 93(5):322-334 [DOI] 10.1159/000510764. [PMID] 33113547.
2020
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.00611. [PMID] 32351504.
2020
Immunophenotyping reveals distinct subgroups of lupus patients based on their activated T cell subsets.
Clinical immunology (Orlando, Fla.). 221 [DOI] 10.1016/j.clim.2020.108602. [PMID] 33007439.
2020
Innate inflammation drives NK cell activation to impair Treg activity.
Journal of autoimmunity. 108 [DOI] 10.1016/j.jaut.2020.102417. [PMID] 32035746.
2020
Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis
Scientific Reports. 10(1) [DOI] 10.1038/s41598-019-56951-5. [PMID] 31959869.
2018
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-22574-5. [PMID] 29540798.
2018
Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.
Current diabetes reports. 18(10) [DOI] 10.1007/s11892-018-1066-5. [PMID] 30168021.
2017
Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.00655. [PMID] 28659913.
2017
T cells display mitochondria hyperpolarization in human type 1 diabetes.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-11056-9. [PMID] 28883439.
2016
Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
Diabetes. 65(12):3765-3775 [PMID] 27669730.
View on: PubMed
2016
Genetic risk analysis of a patient with fulminant autoimmune type 1 diabetes mellitus secondary to combination ipilimumab and nivolumab immunotherapy.
Journal for immunotherapy of cancer. 4 [DOI] 10.1186/s40425-016-0196-z. [PMID] 28031819.
2015
Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.
Journal of immunology (Baltimore, Md. : 1950). 195(1):145-55 [DOI] 10.4049/jimmunol.1402381. [PMID] 25994968.
2015
Normalization of CD4+ T cell metabolism reverses lupus.
Science translational medicine. 7(274) [DOI] 10.1126/scitranslmed.aaa0835. [PMID] 25673763.
2012
Autologous regulatory T cells for the treatment of type 1 diabetes.
Current diabetes reports. 12(5):623-32 [DOI] 10.1007/s11892-012-0304-5. [PMID] 22843491.
2012
Modulation of T Cell Receptor and Interleukin-2 Receptor Signaling in Human Primary Cd4(+) T Cells
Journal of Immunology. 188
2012
Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.
Journal of immunology (Baltimore, Md. : 1950). 189(2):793-803 [DOI] 10.4049/jimmunol.1200411. [PMID] 22711888.
2012
Regulation of T Cell Metabolism and Autoimmunity By the Orphan Nuclear Receptor Err Gamma
Journal of Immunology. 188
2011
Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1.
Journal of immunology (Baltimore, Md. : 1950). 186(12):6673-82 [DOI] 10.4049/jimmunol.1002544. [PMID] 21543644.
2011
Murine models of systemic lupus erythematosus.
Journal of biomedicine & biotechnology. 2011:1-19 [DOI] 10.1155/2011/271694. [PMID] 21403825.
2011
The current concept of T (h) 17 cells and their expanding role in systemic lupus erythematosus.
Arthritis. 2011:810649-10 [DOI] 10.1155/2011/810649. [PMID] 22164330.
2005
Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.
Journal of immunology (Baltimore, Md. : 1950). 175(2):1080-9 [PMID] 16002709.
View on: PubMed
2004
The rare coagulation disorders–review with guidelines for management from the United Kingdom Haemophilia Centre Doctors’ Organisation.
Haemophilia : the official journal of the World Federation of Hemophilia. 10(5):593-628 [PMID] 15357789.
View on: PubMed

Grants

Aug 2021 ACTIVE
Human Pancreas Analysis Program (HPAP)
Role: Co-Investigator
Funding: UNIV OF PENNSYLVANIA via NATL INST OF HLTH NIDDK
Feb 2021 ACTIVE
Type 1 diabetes genetic risk scores for the diagnosis of diabetes type in children of diverse racial and ethnic background
Role: Principal Investigator
Funding: BAYLOR COLLEGE OF MEDICINE via NATL INST OF HLTH NIDDK
Jun 2019 – Sep 2020
Amendment 2 – Genetic Data Analysis
Role: Co-Investigator
Funding: ADAPTIVE BIOTECHNOLOGIES
Jun 2019 – Aug 2020
Single cell sequencing for islet-reactive T cell clonotype and transcript signatures
Role: Co-Investigator
Funding: JDRF
Apr 2019 – Mar 2020
A Composite Serological Risk Score to Predict Type 1 Diabetes Progression and Clinical Diagnosis
Role: Co-Investigator
Funding: JDRF
Mar 2019 – Jul 2019
Safety & Efficacy of Imatinib for Preserving Beta-cell Function in New-Onset T1D
Role: Co-Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via JDRF
Aug 2018 ACTIVE
Model Systems of Mammalian Regeneration
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS

Education

Ph.D. Biomedical Sciences – Immunology
2011 · University of Florida
B.S. Animal Sciences
1998 · University of Vermont

Contact Details

Phones:
Business:
(352) 294-8732
Emails: