Lijun Yang

Lijun Yang,

PROFESSOR

Department: MD-PATHOLOGY
Business Phone: (352) 265-0071
Business Email: yanglj@pathology.ufl.edu

Board Certifications

  • Lijun Yang
    Hematopathology
  • Lijun Yang
    Clinical Pathology
  • Lijun Yang
    Anatomic Pathology

Clinical Profile

Specialties
  • Pathology, Immunology and Laboratory Medicine

Publications

2021
Classical Hodgkin Lymphoma Presenting as a Sigmoid Mass
Gastroenterology Research. 14(3):204-208 [DOI] 10.14740/gr1409. [PMID] 34267838.
2021
Reply.
Arthritis & rheumatology (Hoboken, N.J.). 73(1):176-178 [DOI] 10.1002/art.41478. [PMID] 32776428.
2020
Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon.
Arthritis & rheumatology (Hoboken, N.J.). 72(1):100-113 [DOI] 10.1002/art.41072. [PMID] 31390156.
2020
NF-E2-Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus.
Arthritis & rheumatology (Hoboken, N.J.). 72(10):1707-1720 [DOI] 10.1002/art.41383. [PMID] 32500632.
2018
Primary Gastric EBV-positive Diffuse Large B Cell Lymphoma (DLBCL) of the Elderly with Plasmablastic Differentiation.
In vivo (Athens, Greece). 32(2):413-417 [PMID] 29475930.
View on: PubMed
2017
Uncovering stem cell differentiation factors for salivary gland regeneration by quantitative analysis of differential proteomes.
PloS one. 12(2) [DOI] 10.1371/journal.pone.0169677. [PMID] 28158262.
2016
Cell-Permeable Peptide Blocks Tlr4 Signaling and Improves Islet Allograft Survival
Cell Transplantation. 25(7):1319-1329 [DOI] 10.3727/096368916X690449.
2016
Irisin Inhibits Atherosclerosis By Promoting Endothelial Proliferation Through Microrna126-5P
Journal of the American Heart Association. 5(9) [DOI] 10.1161/JAHA.116.004031. [PMID] 27671318.
2016
Protective Effect of Irisin on Atherosclerosis via Suppressing Oxidized Low Density Lipoprotein Induced Vascular Inflammation and Endothelial Dysfunction.
PloS one. 11(6) [DOI] 10.1371/journal.pone.0158038. [PMID] 27355581.
2015
Animal Models of Interferon Signature Positive Lupus.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00291. [PMID] 26097482.
2015
Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway.
PloS one. 10(8) [DOI] 10.1371/journal.pone.0134662. [PMID] 26241478.
2015
Mechanisms of Autoantibody Production in Systemic Lupus Erythematosus
Frontiers in Immunology. 6 [DOI] 10.3389/fimmu.2015.00228. [PMID] 26029213.
2015
Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.
Arthritis & rheumatology (Hoboken, N.J.). 67(1):225-37 [DOI] 10.1002/art.38882. [PMID] 25252121.
2015
STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells.
Immunology and cell biology. 93(5):461-71 [DOI] 10.1038/icb.2014.103. [PMID] 25582338.
2014
Bacterial Delivery of Talen Proteins for Human Genome Editing
PLoS One. 9(3) [DOI] 10.1371/journal.pone.0091547. [PMID] 24618838.
2014
High level expression, efficient purification, and bioactivity of recombinant human metallothionein 3 (rhMT3) from methylotrophic yeast Pichia pastoris.
Protein expression and purification. 101:121-6 [DOI] 10.1016/j.pep.2014.06.009. [PMID] 24973778.
2014
Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase P38 Map Kinase and Erk Map Kinase Signaling
Diabetes. 63(2):514-525 [DOI] 10.2337/db13-1106. [PMID] 24150604.
2014
Phenotypic Consequences of Tlr7-Driven Interferon and Proinflammatory Cytokine Production in Lupus
Arthritis Research & Therapy. 16(1)
2013
Breast Implant-Associated Alk-Negative Anaplastic Large Cell Lymphoma: a Case Report and Discussion of Possible Pathogenesis
International Journal of Clinical and Experimental Pathology. 6:1631-1642
2013
Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology. 190
2013
Direct reprogramming of fibroblasts to myocytes via bacterial injection of MyoD protein.
Cellular reprogramming. 15(2):117-25 [DOI] 10.1089/cell.2012.0058. [PMID] 23438194.
2013
Genetically Reprogrammed, Liver-Derived Insulin-Producing Cells Are Glucose-Responsive, But Susceptible To Autoimmune Destruction in Settings of Murine Model of Type 1 Diabetes
American Journal of Translational Research. 5:184-199
2013
High level expression, efficient purification and bioactivity assay of recombinant human platelet-derived growth factor AA dimer (PDGF-AA) from methylotrophic yeast Pichia pastoris.
Protein expression and purification. 91(2):221-7 [DOI] 10.1016/j.pep.2013.08.008. [PMID] 23978536.
2013
Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells.
Journal of immunology (Baltimore, Md. : 1950). 190(8):3916-27 [DOI] 10.4049/jimmunol.1201880. [PMID] 23509349.
2013
Novel Autoantigens in Type 1 Diabetes
American Journal of Translational Research. 5:379-392
2013
Novel Detection of Pancreatic and Duodenal Homeobox 1 Autoantibodies (Paa) in Human Sera Using Luciferase Immunoprecipitation Systems (Lips) Assay
International Journal of Clinical and Experimental Pathology. 6:1202-1210
2013
The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation.
Journal of cell science. 126(Pt 16):3638-48 [DOI] 10.1242/jcs.124925. [PMID] 23750005.
2013
Transient receptor potential melastatin 4 channel controls calcium signals and dental follicle stem cell differentiation.
Stem cells (Dayton, Ohio). 31(1):167-77 [DOI] 10.1002/stem.1264. [PMID] 23081848.
2013
Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions.
Molecular biology of the cell. 24(11):1638-48, S1 [DOI] 10.1091/mbc.E12-12-0891. [PMID] 23552692.
2012
Characterization and Immunotherapeutic Implication of a Novel Cerebro-Spinal Fluid-Derived Alk-Positive Anaplastic Large Cell Lymphoma Cell Line
Blood. 120
2012
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
Journal of immunology (Baltimore, Md. : 1950). 188(8):4113-21 [DOI] 10.4049/jimmunol.1103113. [PMID] 22422888.
2012
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.
BMC immunology. 13 [DOI] 10.1186/1471-2172-13-46. [PMID] 22897934.
2011
Bacterial delivery of nuclear proteins into pluripotent and differentiated cells.
PloS one. 6(1) [DOI] 10.1371/journal.pone.0016465. [PMID] 21304583.
2010
Distinct Regulation of Hepatic Nuclear Factor 1 Alpha By Nkx6.1 in Pancreatic Beta Cells
Journal of Biological Chemistry. 285(16):12181-12189 [DOI] 10.1074/jbc.M109.064238. [PMID] 20106981.
2010
Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes.
Laboratory investigation; a journal of technical methods and pathology. 90(1):31-9 [DOI] 10.1038/labinvest.2009.116. [PMID] 19901909.
2010
Reprogramming Liver Cells Into Insulin-Producing Cells By Pancreatic Transcription Factors
Human Gene Therapy. 21
2009
Diverse T-cell differentiation potentials of human fetal thymus, fetal liver, cord blood and adult bone marrow CD34 cells on lentiviral Delta-like-1-modified mouse stromal cells.
Immunology. 128(1 Suppl):e497-505 [DOI] 10.1111/j.1365-2567.2008.03013.x. [PMID] 19740310.
2009
Treatment of type 1 diabetes with adipose tissue-derived stem cells expressing pancreatic duodenal homeobox 1.
Stem cells and development. 18(10):1399-406 [DOI] 10.1089/scd.2009.0010. [PMID] 19245309.
2008
Big mac attack: does it play a direct role for monocytes/macrophages in type 1 diabetes?
Diabetes. 57(11):2922-3 [DOI] 10.2337/db08-1007. [PMID] 18971442.
2008
Hairy Cell Leukemia With Unusual Loss of Cd103 in a Subset of the Neoplastic Population: Immunophenotypic and Cell Cycle Analysis By Flow Cytometry
International Journal of Clinical and Experimental Pathology. 1:381-386
2008
Overcoming immune tolerance against multiple myeloma with lentiviral calnexin-engineered dendritic cells.
Molecular therapy : the journal of the American Society of Gene Therapy. 16(2):269-79 [PMID] 18071334.
View on: PubMed
2008
Pediatric T-Cell Post-Transplant Lymphoproliferative Disorder After Solid Organ Transplantation
Pediatric Blood & Cancer. 50(2):415-418 [DOI] 10.1002/pbc.21072. [PMID] 17051534.
2008
Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy.
Diabetes. 57(3):757-69 [PMID] 18086901.
View on: PubMed
2008
Transcription Factor Directed Differentiation of Human Embryonic Stem Cells Into the Pancreatic Endocrine Lineage
Cell Research. 18(S1):S109-S109 [DOI] 10.1038/cr.2008.199.
2007
Assessment of bone marrow plasma cell infiltrates in multiple myeloma: the added value of CD138 immunohistochemistry.
Human pathology. 38(12):1779-87 [PMID] 17714757.
View on: PubMed
2006
Liver stem cell-derived beta-cell surrogates for treatment of type 1 diabetes.
Autoimmunity reviews. 5(6):409-13 [PMID] 16890895.
View on: PubMed
2004
DRAQ5-based DNA content analysis of hematolymphoid cell subpopulations discriminated by surface antigens and light scatter properties.
Cytometry Part B-Clinical Cytometry. 58(1):47-52 [DOI] 10.1002/cyto.b.20000. [PMID] 14994375.
2003
Gene expression profiling during all-trans retinoic acid-induced cell differentiation of acute promyelocytic leukemia cells.
The Journal of molecular diagnostics : JMD. 5(4):212-21 [PMID] 14573779.
View on: PubMed
2002
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells.
Proceedings of the National Academy of Sciences of the United States of America. 99(12):8078-83 [PMID] 12048252.
View on: PubMed

Grants

Sep 2017 ACTIVE
PATHOGENESIS OF PRISTANE-INDUCED LUPUS
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2016 – Aug 2020
Facilitation of stem cell differentiation in severely injured salivary glands
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Jul 2015 – Dec 2017
Engineering Irisin for Understanding its Benefits to Obestiy
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
Feb 2014 – Jan 2018
Bone marrow stem cell niche dysfunction in human SLE
Role: Principal Investigator
Funding: LUPUS RES INST
Sep 2011 – Aug 2017
Pathogenesis of Autoantibodies in Pristane-Induced Lupus
Role: Project Manager
Funding: NATL INST OF HLTH NIAMS

Patents

Published August 2011
Diabetes Diagnostic, Prophylactic, and Therapeutic Compositions and Methods (CIP)
#US-2012-0039919-A1
Published January 2009
Compositions for Reporgramming a Cell and Uses Therefor
#US-2010-0137202-A1
Published August 2006
Conversion of Hepatic Cells into Functional Insulin-Producing Cells by Introducing Two Transcriptional Factors for a Cure of Diabetes
#2008-0267928-A1
Issued April 2006
Method for Differentiating Rat Hapatic Stem Cells to Insulin-Producing Cells
#7,029,915
Published August 2003
Bone Marrow Cell Differentiation
#US-2004-0063204-A1
Published December 2002
Targeting Leukemia Cells
#US-2003-0124127-A1

Teaching Profile

Courses Taught
2011-2018,2020-2021
DEN6350 General Pathology
2018
GMS7979 Advanced Research

Contact Details

Phones:
Business:
(352) 265-0071
Emails: