Mark A Atkinson

Mark A Atkinson,

Eminent Scholar

Department: MD-PATHOLOGY
Business Phone: (352) 273-8276
Business Email: atkinson@ufl.edu

About Mark A Atkinson

Dr. Atkinson is currently the American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida. He also is the Director of the Diabetes Institute at UF. The author of nearly 600 publications, Dr. Atkinson is beginning his 37th year of investigation into the field of type 1 diabetes. Dr. Atkinson has been the recipient of multiple scientific and humanitarian based awards for these efforts. Those include each of the three from the Juvenile Diabetes Research Foundation (JDRF). The first was the Gerold and Gayla Grodsky award (2001) provided to the outstanding Ph.D. investigating type 1 diabetes. He is a three-time recipient of the Mary Tyler Moore & S. Robert Levine M.D. award for translational research on type 1 diabetes (2004, 2008, and 2014). He was also the recipient of the JDRF’s David Rumbough award for contributions to diabetes research (2005) and the prestigious Eli Lilly Award for Outstanding Scientific Achievement from the American Diabetes Association (ADA) (2004). He also received the Barbara Davis Award for contributions to the field seeking to prevent type 1 diabetes (2015), the Claes Hellerström Award (Sweden) for his efforts promoting pancreas research in this disease (2016), and the 2016 recipient of the outstanding alumni award from his alma mater (The University of Michigan-Dearborn). Most recently, he received the UF College of Medicine Lifetime Achievement Award (2018), the ADA Humanitarian Award (2018) and the ADA Albert Renold Award (2018), College of Medicine Wall of Fame Award (2019), and the Jacobaeus Award from the Novo Nordisk Foundation (2019; the most prestigious international award in Endocrinology and Metabolism). He has also engaged in leadership service to the type 1 diabetes community, with active administrative or advisory service to JDRF, The American Diabetes Association (ADA), The National Institutes of Health, The Immunology of Diabetes Society, and a variety of companies from the pharmaceutical and biotech industry. At present, this includes service as the Executive Director of the JDRF Network for Pancreatic Organ donors with Diabetes (nPOD) program, and he recently completed his term as Steering Committee Chair of the NIH Human Islet Research Network (HIRN); both organizations are directed at major questions in type 1 diabetes with international recognition and impact. He is also a long-standing member of the NIH TrialNet effort, having served in a number of leadership capacities with that organization since its inception. Dr. Atkinson is also one of nine members of the Brehm Coalition for Type 1 Diabetes Research, as well as one of four initial members of the Leona M. and Harry B. Helmsley Charitable Trust’s Type 1 Diabetes Research Initiative. He has served on the state, regional, as well as the national Board of Directors for the ADA, as well as past-memberships on their publications, scientific sessions planning, research review committees. He recently completed service as an Associate Editor of the ADA’s Journal Diabetes and now serves as ad hoc Editor-in-Chief of that journal as well as Diabetes Care. Dr. Atkinson is an internationally recognized authority on multiple aspects pertaining to type 1 diabetes, with particular interests in disease prediction and prevention, the role for environment in the initiation of the disease, stem cells and pancreatic regeneration, the use of animal models in studies of type 1 diabetes pathogenesis and therapy, and the identification of markers of tolerance and immunoregulation. In 2019, Dr. Atkinson surpassed $75M in total extramural funding for his career. With respect to the notions of prevention and cure of type 1 diabetes, Dr. Atkinson has extensively contributed to the performance of some seven “bench to bedside” trials. He has been active in terms of training and education of the next generation of diabetes researchers in many ways throughout his career, including service (two terms) on the NIH NIDDK Training Study Section, undertaking/publishing a 30 year research study on the effectiveness of JDRF training programs, as well as personal mentoring to over 30 graduate students/post-doctoral fellows/clinical fellows/young faculty (K awardees). Dr. Atkinson has been the recipient of numerous funding awards. Finally, he is President of Insulin for Life USA, the world’s second largest charity dedicated to providing insulin to persons living with diabetes in the developing world.

Accomplishments

Jacobaeus Award in Endocrinology and Metabolism
2019 · Novo Nordisk Foundation
Wall of Fame – UF College of Medicine Alumni
2019 · College of Medicine, University of Florida
Albert Renold Award
2018 · American Diabetes Association
Alex and Ani Invisible Angel Award
2018 · JDRF
Humanitarian Award
2018 · American Diabetes Association
University of Florida College of Medicine Lifetime Achievement Award
2018 · University of Florida
Claes Hellerstrom Award
2016 · Upsalla, Sweden
Mary Tyler Moore and S. Robert Levine Clinical Research Award
2015 · JDRF
Julio Santiago Award
2014 · Washington University St. Louis
Davis Award
2012 · Children with Diabetes Foundation
Service Award
2011 · American Diabetes Association
Honorary Lecturer (with Award)
2010 · Edwin Gale Retirement event
Cure Award
2009 · American Diabetes Association
Exemplary Teacher Award
2009 · Univeristy of Florida, College of Medicine
Mary Tyler Moore and S. Robert Levine Clinical Research Award
2008 · Juvenile Diabetes Research Foundation
Howard Hughes Medical Institute undergraduate professor
2007 · University of Florida
Distinguished Service Award for serving as Chair of the Immunology, Immunogenetics, and Transplantation Council
2006 · American Diabetes Association
University of Florida Research Professor
2006 · University of Florida
David Rumbough Award for Scientific Excellence
2005 · JDRF
Hilborn Scholar
2005 · UCLA School of Medicine
Eli Lilly Award for Outstanding Scientific Achievement
2004 · American Diabetes Association
Mary Tyler Moore and S. Robert Levine Clinical Research Award
2004 · Juvenile Diabetes Research Foundation
Distinguished Visiting Professor
2003 · Johns Hopkins University School of Medicine
Gerold & Kayla Grodsky Award for Major Contributions to Diabetes Research
2003 · Juvenile Diabetes Research Foundation
Mary Jane Krugal Research Award
2003 · Juvenile Diabetes Research Foundation
Faculty Basic Science Research Award
2001 · College of Medicine, University of Florida
Outstanding Research Achievement Award
2000 · American Diabetes Association (South Costal Region)
“Distinguished Faculty”
2000 · Juvenile Diabetes Research Foundation
Congressional Briefing on Type 1 Diabetes
1999 · United States Congress
Mary Jane Krugal Research Award
1999 · Juvenile Diabetes Research Foundation
Elected Executive Board Member
1998 · Immunology of Diabetes Society
Sebastian Family / American Diabetes Association Endowed Chair
1998 · American Diabetes Association
University of Florida Research Foundation Professorship
1998 · University of Florida
Mary Jane Krugal Research Award
1997 · Juvenile Diabetes Research Foundation
Partners for a Cure Award
1996 · American Diabetes Association (Florida)
Career Development Award
1993 · Juvenile Diabetes Association
Diabetes Research and Education Foundation Award
1992 · American Diabetes Association
FIRST Award
1992 · National Institutes of Health
Research Development Award (CDA)
1990 · American Diabetes Association
Post-Doctoral Fellowship
1988 · Juvenile Diabetes Research Foundation
Post-Doctoral Fellowship (Mentor Based)
1988 · American Diabetes Association
Medical Guild Research Award for Graduate Research
1987 · University of Florida
Division of Sponsored Research Award
1986 · University of Florida

Research Profile

When a first year graduate student at The University of Florida in 1984, my Mentor provided words of advice that remain a major part of my academic life. In a conversation regarding what areas would form the best focus for a research career in T1D, he responded, “If you pursue three avenues of investigation and find out their answers, you will make a valuable contribution to type 1 diabetes (sic)”. Those recommended efforts were to: • Determine what causes type 1 diabetes. • Identify a means to predict, months to years in advance, who will develop the disease. • Develop a method to cure type 1 diabetes.

Now some 35 years later, with both a sense of happiness and sadness, I can say that these three avenues remain a major focus of my research efforts. Happiness, in that progress has been made by the research community (with some contributions from my research group and collaborators) towards each goal, but at the same time none have been fully addressed. Indeed, progress towards each goal differs quite dramatically. For example, we and others have, to a large extent, developed a means to predict in a population of individuals who is likely to develop T1D. This is a major (if even partial) success. At the same time, its impact remains somewhat muted in that without an answer to the third goal (a method to prevent or cure the disease), efforts for disease prediction have been somewhat underutilized by the public health care community. That said, we are moving closer (and leading efforts) towards testing of agents capable of effectively intervening in the disease which leaves open the discussion of progress towards the first goal, understanding what causes the disorder. Sadly, of all the goals, this one remains the most elusive. Perhaps in part because of this state of progress, I have expanded my efforts to seeing insulin provided to those in third world areas as while not a cure, it does represent a life-saving entity.

Open Researcher and Contributor ID (ORCID)

0000-0001-8489-4782

Areas of Interest
  • type 1 diabetes, pancreatic pathology, immune therapy, autoimmunity, clinical trials, translational research, emerging technologies, psychosocial behaviors, metabolism

Publications

2021
Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes
Diabetologia. 64(10):2279-2291 [DOI] 10.1007/s00125-021-05501-8. [PMID] 34274990.
2021
Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes
Diabetes. 70(5):1038-1050 [DOI] 10.2337/dbi20-0034. [PMID] 33947721.
2021
Defining a cure for type 1 diabetes: a call to action
The lancet. Diabetes & endocrinology. 9(9):553-555 [DOI] 10.1016/S2213-8587(21)00181-9. [PMID] 34339632.
2021
Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes?
The lancet. Diabetes & endocrinology. 9(6):328-329 [DOI] 10.1016/S2213-8587(21)00087-5. [PMID] 33838106.
2021
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.
Diabetes. 70(4):944-954 [DOI] 10.2337/db20-0995. [PMID] 33441381.
2021
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.
Diabetes. 70(4):932-943 [DOI] 10.2337/db20-0937. [PMID] 33419759.
2021
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
Proceedings of the National Academy of Sciences of the United States of America. Biological Sciences. 118(41) [DOI] 10.1073/pnas.2107208118. [PMID] 34611019.
2021
Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas.
The American Journal of Pathology. 191(3):454-462 [DOI] 10.1016/j.ajpath.2020.11.010.
2021
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
Science Immunology. [DOI] 10.1126/sciimmunol.abf3733.
2021
Index60 as an additional diagnostic criterion for type 1 diabetes.
Diabetologia. 64(4):836-844 [DOI] 10.1007/s00125-020-05365-4. [PMID] 33496819.
2021
Insulin Receptor-Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice.
Journal of immunology (Baltimore, Md. : 1950). [DOI] 10.4049/jimmunol.1900357. [PMID] 33658296.
2021
Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.
Genome biology. 22(1) [DOI] 10.1186/s13059-021-02262-w. [PMID] 33478573.
2021
Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation.
Cell reports. 34(5) [DOI] 10.1016/j.celrep.2021.108725. [PMID] 33535031.
2021
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
Scientific Reports. 11(1) [DOI] 10.1038/s41598-021-85659-8. [PMID] 33753784.
2021
Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.
Diabetes. [DOI] 10.2337/db20-1103. [PMID] 33632742.
2021
Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes.
Diabetes. 70(2):313-322 [DOI] 10.2337/dbi20-0026. [PMID] 33472941.
2021
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes
Diabetes. 70(8):1885-1897 [DOI] 10.2337/db21-0070. [PMID] 34035041.
2021
Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices
Jove-Journal of Visualized Experiments. (170) [DOI] 10.3791/62207. [PMID] 33900291.
2021
Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation
Journal of Immunology. 207(3):849-859 [DOI] 10.4049/jimmunol.2000708. [PMID] 34301848.
2021
Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes
Diabetologia. 64(8):1822-1833 [DOI] 10.1007/s00125-021-05468-6. [PMID] 34003304.
2021
Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors
Frontiers in Endocrinology. 12 [DOI] 10.3389/fendo.2021.622647. [PMID] 33841327.
2021
TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes.
Cell. 184(3):827-839.e14 [DOI] 10.1016/j.cell.2020.11.035. [PMID] 33545036.
2021
The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence
Diabetes Care. 44(8):1734-1743 [DOI] 10.2337/dci21-0015. [PMID] 34131045.
2020
An Intolerable Burden: Suicide, Intended Self-Injury and Diabetes
Canadian journal of diabetes (Online). 44(6):541-544 [DOI] 10.1016/j.jcjd.2020.01.008. [PMID] 32305294.
2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.02180. [PMID] 33013915.
2020
Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S.
Diabetes care. 43(6):1360-1362 [DOI] 10.2337/dc19-1941. [PMID] 32273273.
2020
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics. 22(12):948-953 [DOI] 10.1089/dia.2020.0305. [PMID] 32833543.
2020
Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics.
Metabolites. 10(9) [DOI] 10.3390/metabo10090350. [PMID] 32867274.
2020
Early and late C-peptide responses during oral glucose tolerance testing are oppositely predictive of type 1 diabetes in autoantibody-positive individuals.
Diabetes, obesity & metabolism. 22(6):997-1000 [DOI] 10.1111/dom.13982. [PMID] 32003110.
2020
Erratum. Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention. Diabetes Care 2019;42:2228-2236.
Diabetes care. 43(4) [DOI] 10.2337/dc20-er04. [PMID] 32132004.
2020
Evaluation for type 1 diabetes associated autoantibodies in diabetic and non-diabetic Australian terriers and Samoyeds.
Canine medicine and genetics. 7(1) [DOI] 10.1186/s40575-020-00089-5. [PMID] 33323126.
2020
Exocrine Pancreas Dysfunction in Type 1 Diabetes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 26(12):1505-1513 [DOI] 10.4158/EP-2020-0295. [PMID] 33471743.
2020
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Cell metabolism. 32(6):1041-1051.e6 [DOI] 10.1016/j.cmet.2020.11.005. [PMID] 33207244.
2020
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association. 37(12):2160-2168 [DOI] 10.1111/dme.14361. [PMID] 32634859.
2020
Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.574447. [PMID] 33193362.
2020
Innate inflammation drives NK cell activation to impair Treg activity
Journal of Autoimmunity. 108 [DOI] 10.1016/j.jaut.2020.102417. [PMID] 32035746.
2020
Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.
Diabetes. 69(3):413-423 [DOI] 10.2337/db19-0942. [PMID] 31826866.
2020
Intestinal Delivery of Proinsulin and IL-10 via Lactococcus lactis Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.01103. [PMID] 32582188.
2020
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Diabetes care. 43(1):5-12 [DOI] 10.2337/dc19-0880. [PMID] 31753960.
2020
Large-scale electron microscopy database for human type 1 diabetes.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-16287-5. [PMID] 32424134.
2020
Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
Nature Communications. 11(1) [DOI] 10.1038/s41467-020-17040-8. [PMID] 32601271.
2020
Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells.
JCI insight. 5(14) [DOI] 10.1172/jci.insight.136579. [PMID] 32573495.
2020
Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions.
JAMA pediatrics. 174(6):609-617 [DOI] 10.1001/jamapediatrics.2020.0085. [PMID] 32202626.
2020
Organisation of the human pancreas in health and in diabetes.
Diabetologia. 63(10):1966-1973 [DOI] 10.1007/s00125-020-05203-7. [PMID] 32894306.
2020
Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis.
JCI insight. 5(8) [DOI] 10.1172/jci.insight.134525. [PMID] 32324170.
2020
Pancreatlas: Applying an Adaptable Framework to Map the Human Pancreas in Health and Disease.
Patterns (New York, N.Y.). 1(8) [DOI] 10.1016/j.patter.2020.100120. [PMID] 33294866.
2020
Publisher Correction: Long-term culture of human pancreatic slices as a model to study real-time islet regeneration.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-17574-x. [PMID] 32699243.
2020
Removing Formaldehyde-Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin-Fixed Paraffin-Embedded Tissues.
Angewandte Chemie (International ed. in English). 59(50):22584-22590 [DOI] 10.1002/anie.202008847. [PMID] 32762062.
2020
Removing Formaldehyde‐Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin‐Fixed Paraffin‐Embedded Tissues
Angewandte Chemie. 132(50):22773-22779 [DOI] 10.1002/ange.202008847.
2020
Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance.
The Journal of clinical endocrinology and metabolism. 105(5) [DOI] 10.1210/clinem/dgz296. [PMID] 31867614.
2020
Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis.
Scientific reports. 10(1) [DOI] 10.1038/s41598-019-56951-5. [PMID] 31959869.
2020
Teaching Type 1 Diabetes: Creating Stakeholder Engagement in Biomedical Careers Through Undergraduate Research Curriculum
Medical Science Educator. 30(1):69-73 [DOI] 10.1007/s40670-019-00877-0.
2020
Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues.
Diabetes. 69(1):60-66 [DOI] 10.2337/db19-0554. [PMID] 31597639.
2020
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.
Diabetologia. 63(3):588-596 [DOI] 10.1007/s00125-019-05047-w. [PMID] 31768570.
2019
A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.
Cell metabolism. 29(3):755-768.e5 [DOI] 10.1016/j.cmet.2018.11.014. [PMID] 30713109.
2019
Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.
Analytical chemistry. 91(9):5794-5801 [DOI] 10.1021/acs.analchem.9b00024. [PMID] 30843680.
2019
Bringing closure: towards achieving a better understanding of Israel.
Lancet (London, England). 394(10198) [DOI] 10.1016/S0140-6736(19)31760-X. [PMID] 31376991.
2019
Clinical features, biochemistry and HLA-DRB1 status in children and adolescents with diabetes in Dhaka, Bangladesh.
Diabetes research and clinical practice. 158 [DOI] 10.1016/j.diabres.2019.107894. [PMID] 31669629.
2019
Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan.
Diabetes research and clinical practice. 149:9-17 [DOI] 10.1016/j.diabres.2019.01.023. [PMID] 30710658.
2019
Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.
ACS biomaterials science & engineering. 5(5):2631-2646 [DOI] 10.1021/acsbiomaterials.9b00332. [PMID] 31119191.
2019
Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome.
Nature communications. 10(1) [DOI] 10.1038/s41467-019-11460-x. [PMID] 31399563.
2019
Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-38905-z. [PMID] 30862859.
2019
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation
Cell Reports. 29(10):3073-3086.e5 [DOI] 10.1016/j.celrep.2019.11.010. [PMID] 31801074.
2019
Islet amyloidosis in a child with type 1 diabetes.
Islets. 11(2):44-49 [DOI] 10.1080/19382014.2019.1599707. [PMID] 31084520.
2019
Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 67(1):41-52 [DOI] 10.1369/0022155418778546. [PMID] 29771178.
2019
Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].
Diabetologia. 62(6):1100-1103 [DOI] 10.1007/s00125-019-4873-6. [PMID] 31016358.
2019
Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA(1c), and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data
Diabetes. 68(6):1267-1276 [DOI] 10.2337/db19-0057. [PMID] 30967424.
2019
Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.
Cell metabolism. 29(3):769-783.e4 [DOI] 10.1016/j.cmet.2019.01.003. [PMID] 30713110.
2019
NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP).
Diabetes. 68(7):1394-1402 [DOI] 10.2337/db19-0058. [PMID] 31127054.
2019
Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity. 26(4):188-194 [DOI] 10.1097/MED.0000000000000484. [PMID] 31145130.
2019
Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.
Diabetologia. 62(5):744-753 [DOI] 10.1007/s00125-019-4811-7. [PMID] 30675626.
2019
Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.
Journal of clinical medicine. 8(9) [DOI] 10.3390/jcm8091321. [PMID] 31466263.
2019
Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.
Diabetes care. 42(2):281-287 [DOI] 10.2337/dc18-1512. [PMID] 30552130.
2019
Research digest: pioneering an oral GLP-1 receptor agonist.
The lancet. Diabetes & endocrinology. 7(12) [DOI] 10.1016/S2213-8587(19)30360-2. [PMID] 31748168.
2019
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes.
Cell metabolism. 29(5):1045-1060.e10 [DOI] 10.1016/j.cmet.2019.01.021. [PMID] 30799288.
2019
The challenge of modulating β-cell autoimmunity in type 1 diabetes.
The lancet. Diabetes & endocrinology. 7(1):52-64 [DOI] 10.1016/S2213-8587(18)30112-8. [PMID] 30528099.
2019
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Nature. 574(7777):187-192 [DOI] 10.1038/s41586-019-1629-x. [PMID] 31597973.
2019
The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.
Diabetes care. 42(8):1357-1364 [DOI] 10.2337/dc19-0102. [PMID] 31167894.
2019
Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.
Diabetes care. 42(3):406-415 [DOI] 10.2337/dc18-1727. [PMID] 30659077.
2019
Untargeted metabolomic analysis in non-fasted diabetic dogs by UHPLC-HRMS.
Metabolomics : Official journal of the Metabolomic Society. 15(2) [DOI] 10.1007/s11306-019-1477-6. [PMID] 30830416.
2019
Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention
Diabetes Care. 42(12):2228-2236 [DOI] 10.2337/dc19-0593. [PMID] 31558546.
2018
A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
Diabetes care. 41(9):1887-1894 [DOI] 10.2337/dc18-0087. [PMID] 30002199.
2018
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-22574-5. [PMID] 29540798.
2018
Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.
Frontiers in endocrinology. 9 [DOI] 10.3389/fendo.2018.00791. [PMID] 30687234.
2018
Hospital time prior to death and pancreas histopathology: implications for future studies.
Diabetologia. 61(4):954-958 [DOI] 10.1007/s00125-017-4494-x. [PMID] 29128936.
2018
Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes.
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2018
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.
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2018
Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes.
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2018
Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.
The Journal of clinical investigation. 128(5):1888-1902 [DOI] 10.1172/JCI97739. [PMID] 29438107.
2018
Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of
Chemical science. 9(34):6944-6951 [DOI] 10.1039/c8sc02680g. [PMID] 30210768.
2018
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism. 103(1):35-45 [DOI] 10.1210/jc.2017-01159. [PMID] 28938416.
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Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.
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2018
Remnant β Cells in Recent-Onset Type 1 Diabetes Have Essentially Normal Gene Expression and Function, but α Cells are Significantly Compromised
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2018
Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience.
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2018
Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.
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2018
Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes.
Diabetes care. 41(4):653-661 [DOI] 10.2337/dc17-0806. [PMID] 29559451.
2018
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Cell reports. 22(10):2667-2676 [DOI] 10.1016/j.celrep.2018.02.032. [PMID] 29514095.
2017
Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity.
JAMA pediatrics. 171(12):1217-1225 [DOI] 10.1001/jamapediatrics.2017.2905. [PMID] 29052687.
2017
Beta cell mass versus function in type 1 diabetes: truth or dare?
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2017
Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?
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2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
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2017
Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes.
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2017
Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials.
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2017
Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy.
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2017
Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.
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2017
Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950). 198(11):4255-4267 [DOI] 10.4049/jimmunol.1700024. [PMID] 28461573.
2017
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes.
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2017
Impact of blood collection and processing on peripheral blood gene expression profiling in type 1 diabetes.
BMC genomics. 18(1) [DOI] 10.1186/s12864-017-3949-2. [PMID] 28821222.
2017
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.
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2017
Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.
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2017
Mary Tyler Moore (1936-2017): Diabetes Educator and Advocate.
Diabetes care. 40(6):732-735 [DOI] 10.2337/dci17-0015. [PMID] 28533256.
2017
More on Intralymphatic Injection of Autoantigen in Type 1 Diabetes.
The New England journal of medicine. 377(4) [DOI] 10.1056/NEJMc1703468. [PMID] 28748691.
2017
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
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2017
Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.
Scientific reports. 7 [DOI] 10.1038/srep42372. [PMID] 28205558.
2017
Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform.
Proceedings of the National Academy of Sciences of the United States of America. 114(38):10196-10201 [DOI] 10.1073/pnas.1711169114. [PMID] 28874568.
2017
Raising Awareness: The Need to Promote Allocation of Pancreata From Rare Nondiabetic Donors With Pancreatic Islet Autoimmunity to Type 1 Diabetes Research.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17(1):306-307 [DOI] 10.1111/ajt.13983. [PMID] 27460917.
2017
Re-addressing the 2013 consensus guidelines for the diagnosis of insulits in human type 1 diabetes – Is change necessary?
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2017
Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.
Diabetologia. 60(1):35-38 [PMID] 27785529.
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Response to Comment on Rodriguez-Calvo et al. Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes 2017;66:1334-1345.
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2017
Serum Trypsinogen Levels in Type 1 Diabetes.
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2017
T cells display mitochondria hyperpolarization in human type 1 diabetes.
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2017
Tracking the Antibody Immunome in Type 1 Diabetes Using Protein Arrays.
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2017
Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy.
Journal of immunology (Baltimore, Md. : 1950). 199(11):3757-3770 [DOI] 10.4049/jimmunol.1700822. [PMID] 29055002.
2017
Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.
Diabetes. 66(12):3061-3071 [DOI] 10.2337/db17-0106. [PMID] 28877912.
2017
Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes.
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β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?
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2016
A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.
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2016
Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.
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2016
An Interview with Dr. Mark Atkinson on 100 Years of Type 1 Diabetes Care and Research
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2016
Analysis of Self-Antigen Specificity of Islet Infiltrating T Cells from Human Donors with Type 1 Diabetes
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2016
Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
Diabetes. 65(12):3765-3775 [PMID] 27669730.
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2016
Autoimmune manifestations in aged mice arise from early-life immune dysregulation.
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Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.
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2016
Factors impeding the discovery of an intervention-based treatment for type 1 diabetes.
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2016
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2016
Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays.
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2016
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
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2016
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.
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2016
Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes.
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2016
Pancreatic and Ductal Cell Hyperplasia/Dysplasia with Obstructive Chronic Pancreatitis: An Association with Reduced Pancreatic Weight in Type 1 Diabetes. Reply to Kobayashi T., Aida K., Fukui T. et al [letter] and Saisho Y. [letter]
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2016
Sulfatide preserves insulin crystals not by being integrated in the lattice but by stabilizing their surface
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Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.
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The influence of type 1 diabetes on pancreatic weight.
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2016
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2016
Towards a Functional Hypothesis Relating Anti-Islet Autoimmunity to the Dietary Impact on Microbial Communities and Butyrate Production
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Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production.
Microbiome. 4 [DOI] 10.1186/s40168-016-0163-4. [PMID] 27114075.
2016
Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile.
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2016
Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease.
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Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease.
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2015
A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.
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2015
A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.
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2015
A Friend or Foe?
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2015
A run on the biobank: what have we learned about type 1 diabetes from the nPOD tissue repository?
Current opinion in endocrinology, diabetes, and obesity. 22(4):290-5 [DOI] 10.1097/MED.0000000000000171. [PMID] 26087339.
2015
Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.
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2015
Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.
The Journal of clinical investigation. 125(1):448-55 [DOI] 10.1172/JCI78492. [PMID] 25500887.
2015
Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes.
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2015
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
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2015
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-Prone Bi-Congenic B6.NODC11bxC1tb Mice
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Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.
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Current concepts on the pathogenesis of type 1 diabetes–considerations for attempts to prevent and reverse the disease.
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2015
Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.
Journal of immunology (Baltimore, Md. : 1950). 195(1):145-55 [DOI] 10.4049/jimmunol.1402381. [PMID] 25994968.
2015
Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes.
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2015
Hla-Associated Susceptibility To Type 1 Diabetes in the Developing World Reveals Differences Among Populations; Implications for Prediction and Intervention
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2015
Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia.
American journal of medical genetics. Part A. 167A(1):69-79 [DOI] 10.1002/ajmg.a.36810. [PMID] 25355237.
2015
Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice.
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2015
Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigens.
Diabetes. 64(1):158-71 [DOI] 10.2337/db13-1639. [PMID] 25187361.
2015
Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.
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2015
Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics.
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2015
The role for gut permeability in the pathogenesis of type 1 diabetes–a solid or leaky concept?
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2015
The role for gut permeability in the pathogenesis of type 1 diabetes–a solid or leaky concept?
Pediatric diabetes. 16(7):485-92 [DOI] 10.1111/pedi.12305. [PMID] 26269193.
2015
The streetlight effect in type 1 diabetes.
Diabetes. 64(4):1081-90 [DOI] 10.2337/db14-1208. [PMID] 25805758.
2015
Type 1 Diabetes: Around the World With Hla
Human Immunology. 76(4)
2014
Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes.
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2014
Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres.
Journal of materials chemistry. B. 2(17):2562-2574 [PMID] 24778809.
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Compromised gut microbiota networks in children with anti-islet cell autoimmunity.
Diabetes. 63(6):2006-14 [DOI] 10.2337/db13-1676. [PMID] 24608442.
2014
Effect of a single autologous cord blood infusion on beta-cell and immune function in children with new onset type 1 diabetes: a non-randomized, controlled trial.
Pediatric diabetes. 15(2):100-9 [DOI] 10.1111/pedi.12072. [PMID] 24102806.
2014
Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas
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GABA promotes human β-cell proliferation and modulates glucose homeostasis.
Diabetes. 63(12):4197-205 [DOI] 10.2337/db14-0153. [PMID] 25008178.
2014
Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.
Journal of immunology (Baltimore, Md. : 1950). 193(3):1024-34 [DOI] 10.4049/jimmunol.1303230. [PMID] 24973447.
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Losing a grip on the notion of β-cell specificity for immune responses in type 1 diabetes: can we handle the truth?
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Mechanisms of Pdl1-Mediated Regulation of Autoimmune Diabetes (Vol 125, Pg 16, 2007)
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2014
Nardilysin-Dependent Proteolysis of Cell-Associated Vtcn1 (B7-H4) Marks Type 1 Diabetes Development
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2014
Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development.
Diabetes. 63(10):3470-82 [DOI] 10.2337/db14-0213. [PMID] 24848066.
2014
New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.
Current diabetes reports. 14(10) [DOI] 10.1007/s11892-014-0530-0. [PMID] 25142715.
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Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice.
Diabetes. 63(8):2876-87 [DOI] 10.2337/db13-1236. [PMID] 24677716.
2014
Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora’s box
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Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora’s box.
Diabetologia. 57(4):656-9 [DOI] 10.1007/s00125-013-3159-7. [PMID] 24442510.
2014
Pancreatic Biopsies in Type 1 Diabetes: Revisiting the Myth of Pandora’s Box
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Stem cells to insulin secreting cells: two steps forward and now a time to pause?
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The intestinal microbiome in type 1 diabetes.
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2014
The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.
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Type 1 Diabetes
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2013
Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19(7):1126-9 [DOI] 10.1016/j.bbmt.2013.04.011. [PMID] 23611977.
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Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes.
American journal of translational research. 5(2):184-99 [PMID] 23573363.
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Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma.
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2013
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Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function.
Diabetes. 62(8):2870-8 [DOI] 10.2337/db12-1619. [PMID] 23835340.
2013
Interleukin-1 Antagonism in Type 1 Diabetes of Recent Onset: Two Multicentre, Randomised, Double-Blind, Placebo-Controlled Trials
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Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors.
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2013
Nardilysin-Dependent Proteolysis of Cell-Associated Vtcn1: a Novel Pathway and Biomarker of Type 1 Diabetes Development
Journal of Immunology. 190
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Novel detection of pancreatic and duodenal homeobox 1 autoantibodies (PAA) in human sera using luciferase immunoprecipitation systems (LIPS) assay.
International journal of clinical and experimental pathology. 6(6):1202-10 [PMID] 23696946.
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2013
Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes.
PloS one. 8(10) [DOI] 10.1371/journal.pone.0076919. [PMID] 24204704.
2013
Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials.
Diabetes. 62(1):9-17 [DOI] 10.2337/db12-0562. [PMID] 23258904.
2013
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Diabetes. 62(10):E19-E22 [DOI] 10.2337/db13-0996. [PMID] 24065800.
2013
Serological autoantibody profiling of type 1 diabetes by protein arrays.
Journal of proteomics. 94:486-96 [DOI] 10.1016/j.jprot.2013.10.018. [PMID] 24148850.
2013
Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes.
The Journal of experimental medicine. 210(1):191-203 [DOI] 10.1084/jem.20111843. [PMID] 23277452.
2013
The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.
Journal of autoimmunity. 44:8-12 [DOI] 10.1016/j.jaut.2013.06.001. [PMID] 23891168.
2013
The diagnosis of insulitis in human type 1 diabetes.
Diabetologia. 56(11):2541-3 [DOI] 10.1007/s00125-013-3043-5. [PMID] 24006089.
2013
The Effects of Inpatient Hybrid Closed-loop Therapy Initiated Within 1 Week of Type 1 Diabetes Diagnosis
Diabetes Technology & Therapeutics. 15:401-408
2013
The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus.
Arthritis research & therapy. 15(2) [DOI] 10.1186/ar4208. [PMID] 23566364.
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Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice.
PloS one. 8(2) [DOI] 10.1371/journal.pone.0054712. [PMID] 23405091.
2013
Transplant Tolerance To Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen
American Journal of Transplantation. 13(8):1963-1975 [DOI] 10.1111/ajt.12333. [PMID] 23834659.
2013
Trying to make a difference for those with Type 1 Diabetes: a lesson in patience as well as a willingness to fail mightily
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Trying to make a difference for those with Type 1 diabetes: a lesson in patience as well as a willingness to fail mightily.
Expert review of endocrinology & metabolism. 8(4):323-327 [DOI] 10.1586/17446651.2013.811869. [PMID] 30736146.
2013
γ-Aminobutyric acid regulates both the survival and replication of human β-cells.
Diabetes. 62(11):3760-5 [DOI] 10.2337/db13-0931. [PMID] 23995958.
2012
Anti-Thymocyte Globulin (Atg) Differentially Depletes Naive and Memory T Cells and Permits Memory-Type Regulatory T Cells
Blood. 120
2012
Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.
BMC immunology. 13 [DOI] 10.1186/1471-2172-13-70. [PMID] 23237483.
2012
Central role for interleukin-2 in type 1 diabetes.
Diabetes. 61(1):14-22 [DOI] 10.2337/db11-1213. [PMID] 22187370.
2012
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Journal of visualized experiments : JoVE. (63) [DOI] 10.3791/4039. [PMID] 22665046.
2012
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.
The Journal of experimental medicine. 209(1):51-60 [DOI] 10.1084/jem.20111187. [PMID] 22213807.
2012
Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease.
Diabetologia. 55(11):2868-77 [DOI] 10.1007/s00125-012-2672-4. [PMID] 22875196.
2012
Formation of a human β-cell population within pancreatic islets is set early in life.
The Journal of clinical endocrinology and metabolism. 97(9):3197-206 [DOI] 10.1210/jc.2012-1206. [PMID] 22745242.
2012
In Vitro Generation of Functional Insulin-Producing Cells from Human Bone Marrow-Derived Stem Cells, but Long-Term Culture Running Risk of Malignant Transformation
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In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation.
American journal of stem cells. 1(2):114-127 [PMID] 22833839.
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2012
Mixed chimerism and growth factors augment β cell regeneration and reverse late-stage type 1 diabetes.
Science translational medicine. 4(133) [DOI] 10.1126/scitranslmed.3003835. [PMID] 22572882.
2012
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.
Diabetes/metabolism research and reviews. 28(7):608-17 [DOI] 10.1002/dmrr.2316. [PMID] 22585677.
2012
No increased rate of acute myocardial infarction or stroke among patients with ankylosing spondylitis-a retrospective cohort study using routine data.
Seminars in arthritis and rheumatism. 42(2):140-5 [DOI] 10.1016/j.semarthrit.2012.02.008. [PMID] 22494565.
2012
On the Road To the Insulin Centenary
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Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.
JAMA. 308(22):2337-9 [DOI] 10.1001/jama.2012.15008. [PMID] 23232891.
2012
Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.
The Journal of clinical investigation. 122(5):1717-25 [DOI] 10.1172/JCI60530. [PMID] 22484814.
2012
Serum levels of soluble CD25 as a marker for hepatocellular carcinoma.
Oncology letters. 4(4):840-846 [PMID] 23205111.
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2012
The pathogenesis and natural history of type 1 diabetes.
Cold Spring Harbor perspectives in medicine. 2(11) [DOI] 10.1101/cshperspect.a007641. [PMID] 23125199.
2012
The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice.
PloS one. 7(5) [DOI] 10.1371/journal.pone.0036079. [PMID] 22615750.
2012
Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor.
Journal of clinical immunology. 32(5):1038-47 [DOI] 10.1007/s10875-012-9707-y. [PMID] 22661285.
2011
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
Journal of translational medicine. 9 [DOI] 10.1186/1479-5876-9-21. [PMID] 21345239.
2011
Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails To Preserve C-Peptide
Diabetes Care. 34(12):2567-2569 [DOI] 10.2337/dc11-1406. [PMID] 22011412.
2011
B cells enhance early innate immune responses during bacterial sepsis.
The Journal of experimental medicine. 208(8):1673-82 [DOI] 10.1084/jem.20101715. [PMID] 21746813.
2011
Combinatorial treatment of bone marrow stem cells and stromal cell-derived factor 1 improves glycemia and insulin production in diabetic mice.
Molecular and cellular endocrinology. 345(1-2):88-96 [DOI] 10.1016/j.mce.2011.07.024. [PMID] 21801807.
2011
Evaluating preclinical efficacy.
Science translational medicine. 3(96) [DOI] 10.1126/scitranslmed.3002757. [PMID] 21849661.
2011
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.
PloS one. 6(10) [DOI] 10.1371/journal.pone.0025792. [PMID] 22043294.
2011
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.
Diabetes. 60(5):1370-9 [DOI] 10.2337/db10-1797. [PMID] 21525508.
2011
Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice.
Pancreas. 40(7):1147-9 [DOI] 10.1097/MPA.0b013e31821ffabe. [PMID] 21926555.
2011
Immune Modulation in Early Onset Pompe Disease
Molecular Genetics and Metabolism. 102(2):S31-S32 [DOI] 10.1016/j.ymgme.2010.11.107.
2011
Induction of mixed chimerism with MHC-mismatched but not matched bone marrow transplants results in thymic deletion of host-type autoreactive T-cells in NOD mice.
Diabetes. 60(2):555-64 [DOI] 10.2337/db10-0827. [PMID] 21270266.
2011
Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.
Journal of immunology (Baltimore, Md. : 1950). 186(6):3538-46 [DOI] 10.4049/jimmunol.1001864. [PMID] 21317395.
2011
It’s time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes.
Diabetes. 60(2):361-3 [DOI] 10.2337/db10-1506. [PMID] 21270247.
2011
It’S Time To Mow the Gras in Type 1 Diabetes
Diabetes. 60(11):2669-2671 [DOI] 10.2337/db11-1158. [PMID] 22025772.
2011
Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies.
Diabetes. 60(11):2914-21 [DOI] 10.2337/db11-0705. [PMID] 21926271.
2011
Mesenchymal stem cells express serine protease inhibitor to evade the host immune response.
Blood. 117(4):1176-83 [DOI] 10.1182/blood-2010-06-287979. [PMID] 21076046.
2011
Microbiology of Type 1 Diabetes: Possible Implications for Management of the Disease
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2011
Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes.
Diabetes. 60(5):1383-92 [DOI] 10.2337/db10-0907. [PMID] 21441442.
2011
Persistence is the twin sister of excellence: an important lesson for attempts to prevent and reverse type 1 diabetes.
Diabetes. 60(3):693-4 [DOI] 10.2337/db10-1810. [PMID] 21357468.
2011
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.
Diabetes. 60(8):2086-91 [DOI] 10.2337/db11-0373. [PMID] 21659497.
2011
Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.
PloS one. 6(12) [DOI] 10.1371/journal.pone.0028434. [PMID] 22174806.
2011
Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.
Diabetes. 60(10):2566-70 [DOI] 10.2337/db11-0576. [PMID] 21844098.
2011
Stem Cell Therapy of Diabetes: Effective Treatment with Stromal Cell-Derived Factor 1 plus Bone Marrow Stem Cells in the Liver of Diabetic Mice
Molecular and Cellular Endocrinology. 345:88-96
2011
Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.
Journal of immunology (Baltimore, Md. : 1950). 187(11):5921-30 [DOI] 10.4049/jimmunol.1100746. [PMID] 22043012.
2011
The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells.
Journal of immunology (Baltimore, Md. : 1950). 187(5):2252-60 [DOI] 10.4049/jimmunol.1003981. [PMID] 21795594.
2011
The pancreas in human type 1 diabetes.
Seminars in immunopathology. 33(1):29-43 [DOI] 10.1007/s00281-010-0208-x. [PMID] 20495921.
2011
The threshold hypothesis: solving the equation of nurture vs nature in type 1 diabetes.
Diabetologia. 54(9):2232-6 [DOI] 10.1007/s00125-011-2244-z. [PMID] 21773685.
2011
Toward Defining the Autoimmune Microbiome for Type 1 Diabetes
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Toward defining the autoimmune microbiome for type 1 diabetes.
The ISME journal. 5(1):82-91 [DOI] 10.1038/ismej.2010.92. [PMID] 20613793.
2010
A model for studying the impact of nurture on nature: Development of diabetes in multicongenic mice with an epigenetic gene expression dysregulation defect from the nonobese diabetic mouse (NOD)
Journal of Immunology. 175(7):4561-4565
2010
A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice.
Diabetes. 59(9):2253-64 [DOI] 10.2337/db09-1264. [PMID] 20805386.
2010
Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant.
Diabetes. 59(2):433-9 [DOI] 10.2337/db09-1168. [PMID] 19934002.
2010
Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
Journal of pediatric gastroenterology and nutrition. 51(4):414-7 [DOI] 10.1097/MPG.0b013e3181dd913a. [PMID] 20706153.
2010
Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes.
Diabetes. 59(12):3139-47 [DOI] 10.2337/db10-0542. [PMID] 20841611.
2010
Developing Combination Immunotherapies for Type 1 Diabetes: Recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
Clinical and Experimental Immunology. 160(2):176-184
2010
Dimorphic Histopathology of Long Standing Childhood Onset Diabetes
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Dimorphic histopathology of long-standing childhood-onset diabetes.
Diabetologia. 53(4):690-8 [DOI] 10.1007/s00125-009-1642-y. [PMID] 20062967.
2010
Efforts to prevent and halt autoimmune beta cell destruction.
Endocrinology and metabolism clinics of North America. 39(3):527-39 [DOI] 10.1016/j.ecl.2010.05.006. [PMID] 20723818.
2010
Estimating the cost of type 1 diabetes in the U.S.: a propensity score matching method.
PloS one. 5(7) [DOI] 10.1371/journal.pone.0011501. [PMID] 20634976.
2010
Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.
Journal of diabetes and its complications. 24(3):163-7 [DOI] 10.1016/j.jdiacomp.2008.12.004. [PMID] 19217320.
2010
Genetic Control of B-Cell Mass Homeostasis
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2010
Hepatocellular carcinoma immunopathogenesis: clinical evidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25).
Digestive diseases and sciences. 55(2):484-95 [DOI] 10.1007/s10620-009-0955-5. [PMID] 19714465.
2010
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
PloS one. 5(7) [DOI] 10.1371/journal.pone.0011726. [PMID] 20668510.
2010
Induction of chimerism permits low-dose islet grafts in the liver or pancreas to reverse refractory autoimmune diabetes.
Diabetes. 59(9):2228-36 [DOI] 10.2337/db10-0450. [PMID] 20530743.
2010
Influence of Serum and CD25 Stability on Regulatory T cell Activity: Implications for Immune Regulation
PLoS One. 4
2010
Influence of serum and soluble CD25 (sCD25) on regulatory and effector T-cell function in hepatocellular carcinoma.
Scandinavian journal of immunology. 72(4):293-301 [DOI] 10.1111/j.1365-3083.2010.02427.x. [PMID] 20883314.
2010
Intradermal Alpha 1-Antitrypsin Therapy Avoids Fatal Anaphylaxis, Prevents Type 1 Diabetes and Reverses Hyperglycaemia in the Nod Mouse Model of the Disease
Diabetologia. 53(10):2198-2204 [DOI] 10.1007/s00125-010-1829-2. [PMID] 20593162.
2010
Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
PloS one. 5(5) [DOI] 10.1371/journal.pone.0010507. [PMID] 20463897.
2010
The Juvenile Diabetes Research Foundation at forty: updates of research in type 1 diabetes.
Diabetes. 59(7):1575-7 [DOI] 10.2337/db10-0622. [PMID] 20587801.
2010
The Type 1 Diabetes PhysioLab® Platform: A Validated Physiologically Based Mathematical Model of Pathogenesis in the Non-Obese Diabetic Mouse
Clinical and Experimental Immunology. 161:250-267
2010
Type I diabetes. Preface.
Endocrinology and metabolism clinics of North America. 39(3):xvii-xviii [DOI] 10.1016/j.ecl.2010.05.012. [PMID] 20723814.
2009
Amelioration of Insulitis and Reversal of Diabetes in Nod Mice By Murine Anti-Thymocyte Globulin and Granulocyte-Colony Stimulating Factor Combination Therapy
Clinical Immunology. 131:S48-S49 [DOI] 10.1016/j.clim.2009.03.137.
2009
Anti-Mouse Thymocyte Globulin Administration Alters Dendritic Cell Profile and Function in Nod Mice To Suppress Diabetogenic Responses.
American Journal of Transplantation. 9
2009
Autologous umbilical cord blood transfusion in very young children with type 1 diabetes.
Diabetes care. 32(11):2041-6 [DOI] 10.2337/dc09-0967. [PMID] 19875605.
2009
Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model.
The ISME journal. 3(5):536-48 [DOI] 10.1038/ismej.2009.5. [PMID] 19225551.
2009
Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes.
Nature immunology. 10(9):1026-33 [DOI] 10.1038/ni.1773. [PMID] 19668219.
2009
Diabetic eNOS Knockout Mice Develop Accelerated Retinopathy
Investigative Ophthalmology & Visual Science. 50(13)
2009
Expansion of human regulatory T-cells from patients with type 1 diabetes.
Diabetes. 58(3):652-62 [DOI] 10.2337/db08-1168. [PMID] 19074986.
2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes. 58(10):2277-84 [DOI] 10.2337/db09-0557. [PMID] 19628781.
2009
Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950). 183(2):993-1004 [DOI] 10.4049/jimmunol.0900803. [PMID] 19561093.
2009
Influence of Fecal Sample Storage on Bacterial Community Diversity
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Influence of fecal sample storage on bacterial community diversity.
The open microbiology journal. 3:40-6 [DOI] 10.2174/1874285800903010040. [PMID] 19440250.
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Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
PloS one. 4(11) [DOI] 10.1371/journal.pone.0007980. [PMID] 19956753.
2009
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
The American journal of pathology. 174(4):1221-9 [DOI] 10.2353/ajpath.2009.080605. [PMID] 19246639.
2009
Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation.
Pediatric research. 65(3):311-6 [DOI] 10.1203/PDR.0b013e3181961e80. [PMID] 19047917.
2009
Network for Pancreatic Organ Donors With Diabetes (Npod): Donor Demographics and Early Progress Report
Hormone Research. 72:156-157
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Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.
Diabetologia. 52(2):262-70 [DOI] 10.1007/s00125-008-1200-z. [PMID] 19002428.
2009
Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells.
Journal of thrombosis and haemostasis : JTH. 7(9):1523-32 [DOI] 10.1111/j.1538-7836.2009.03548.x. [PMID] 19583824.
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Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
Journal of immunology (Baltimore, Md. : 1950). 182(8):4608-15 [DOI] 10.4049/jimmunol.0713269. [PMID] 19342635.
2009
Rapamycin prevents and breaks the anti-CD3-induced tolerance in NOD mice.
Diabetes. 58(4):875-81 [DOI] 10.2337/db08-1432. [PMID] 19151201.
2009
T regulatory cell function in idiopathic minimal lesion nephrotic syndrome.
Pediatric nephrology (Berlin, Germany). 24(9):1691-8 [DOI] 10.1007/s00467-009-1214-x. [PMID] 19495805.
2009
Taking a daily vitamin to prevent type 1 diabetes?
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2009
The pancreas in human type 1 diabetes: providing new answers to age-old questions.
Current opinion in endocrinology, diabetes, and obesity. 16(4):279-85 [DOI] 10.1097/MED.0b013e32832e06ba. [PMID] 19502978.
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The road not taken: a path to curing type 1 diabetes?
European journal of immunology. 39(8):2054-8 [DOI] 10.1002/eji.200939517. [PMID] 19672902.
2009
Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment.
Diabetes care. 32(11):1977-9 [DOI] 10.2337/dc09-1089. [PMID] 19675194.
2008
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Clinical immunology (Orlando, Fla.). 126(3):303-14 [PMID] 18096436.
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A Prophylactic Protocol for the Prevention of Inhibitor Formation in Gene Therapy for Hemophilia B By Shifting the Balance From An Effector To a Regulatory T Cell Response
Blood. 112
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Addressing Ceiling Effects in Health Status Measures: a Comparison of Techniques Applied To Measures for People With Hiv Disease
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2008
Alpha-1 antitrypsin treatment of spontaneously diabetic nonobese diabetic mice receiving islet allografts.
Transplantation proceedings. 40(2):457-8 [DOI] 10.1016/j.transproceed.2008.02.010. [PMID] 18374100.
2008
Autologous umbilical cord blood infusion for type 1 diabetes.
Experimental hematology. 36(6):710-5 [DOI] 10.1016/j.exphem.2008.01.009. [PMID] 18358588.
2008
CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.
Cytokine. 44(1):154-9 [DOI] 10.1016/j.cyto.2008.07.468. [PMID] 18778952.
2008
Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice.
Diabetes. 57(12):3281-8 [DOI] 10.2337/db08-0688. [PMID] 18835930.
2008
Comparative analysis of the islet proteome between NOD/Lt and ALR/Lt mice.
Annals of the New York Academy of Sciences. 1150:68-71 [DOI] 10.1196/annals.1447.002. [PMID] 19120270.
2008
Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
Annals of the New York Academy of Sciences. 1150:152-6 [DOI] 10.1196/annals.1447.049. [PMID] 19120286.
2008
Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice.
Clinical and experimental immunology. 154(1):15-21 [DOI] 10.1111/j.1365-2249.2008.03721.x. [PMID] 18759852.
2008
Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes.
Diabetes. 57(7):1759-67 [DOI] 10.2337/db08-0180. [PMID] 18586907.
2008
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes. 57(2):405-14 [PMID] 18039815.
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2008
Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.
Pediatric research. 63(3):303-7 [PMID] 18091354.
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Prolonged islet allograft survival by alpha-1 antitrypsin: the role of humoral immunity.
Transplantation proceedings. 40(2):455-6 [DOI] 10.1016/j.transproceed.2008.02.009. [PMID] 18374099.
2008
Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy.
Diabetes. 57(3):757-69 [PMID] 18086901.
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Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.
The American journal of pathology. 173(1):154-60 [DOI] 10.2353/ajpath.2008.070963. [PMID] 18511516.
2008
The “perfect storm” for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.
Diabetes. 57(10):2555-62 [DOI] 10.2337/db08-0331. [PMID] 18820210.
2008
The IDS Conducts Standardization of Assays for the Measurement of Autoantibodies and of T Cells in Autoimmune Diabetes
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The IDS conducts standardization of assays for the measurement of autoantibodies and of T cells in autoimmune diabetes. Preface.
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The Pivotal Role of Vegf On Glomerular Macrophage Infiltration in Advanced Diabetic Nephropathy
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The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.
Laboratory investigation; a journal of technical methods and pathology. 88(9):949-61 [DOI] 10.1038/labinvest.2008.60. [PMID] 18607348.
2007
Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7(5):1112-20 [PMID] 17456199.
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Alpha-1 antitrypsin treatment of spontaneously diabetic NOD mice receiving islet allografts
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PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).
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Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy.
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A comprehensive review of interventions in the NOD mouse and implications for translation.
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ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can’t we prevent or reverse this disease?
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An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells
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An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells.
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Autoimmunity to Glutamic Acid Decarboxylase in the Neurodegenerative Disorder Batten Disease
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Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.
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Donor CD8+ T cells facilitate induction of chimerism and tolerance without GVHD in autoimmune NOD mice conditioned with anti-CD3 mAb.
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Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
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Gene Therapy for Prevention and Treatment of Type 1 Diabetes
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Glucose Transporter-2 (GLUT2) Promoter Mediated Transgenic Insulin Production Reduces Hyperglycemia in Diabetic Mice
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Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice.
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High Frequency of Abnormal Glucose Tolerance in DQA1*02/DQB1*0602 Relatives Identified as Part of the Diabetes Prevention Trial–Type 1 Diabetes
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IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease.
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Impact of humoral immune response on distribution and efficacy of recombinant adeno-associated virus-derived acid alpha-glucosidase in a model of glycogen storage disease type II.
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Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
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Islet cell autoantibodies: a case of a premature obituary.
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Lessons from attempts to prevent type 1 diabetes—potential implications for type 2 diabetes
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Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
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Neonatal Nutritional Interventions in the Prevention of Type 1 Diabetes
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Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.
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Pancreatic regeneration in type 1 diabetes: dreams on a deserted islet?
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SUMO Wrestling with Type 1 Diabetes
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SUMO wrestling with type 1 diabetes.
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Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect eveidence for islet regeneration? Commentary
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Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.
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Type 1 diabetes mellitus: etiology, presentation, and management.
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Viruses and Diabetes-Reply
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A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.
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A Piece of Nucleic Acid Surrounded By Controversy: Coxsackieviruses and the Causes of Type 1 Diabetes
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Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes.
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Animal Models Have Little to Teach Us About Type 1 Diabetes
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Assessing the quality of immunoassay systems: Radioimmunoassays and enzyme, fluorescence, and luminescence immunoassays; approved guideline
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Bioluminescent Monitoring of Islet Graft Survival After Transplantation
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Bioluminescent monitoring of islet graft survival after transplantation.
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Gene Therapy for Type 1 Diabetes: Metabolism, Immunity, Islet Cell Preservation and Regeneration
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Glutamic Acid Decarboxylase Autoimmunity in Batten Disease and Other Disorders
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Glutamic acid decarboxylase autoimmunity in Batten disease and other disorders.
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Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.
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Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity.
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In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow.
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Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice.
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Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus–a new surrogate measure of non-progression?
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Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes.
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Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice.
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Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes.
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Timing of initial cereal exposure in infancy and risk of islet autoimmunity.
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Von-Herrath.: Satisfaction (Not) Guaranteed: Re-evaluating the Use of Animal Models of Type-1 Diabetes
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Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
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Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.
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Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.
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Glucose-Responsive Expression of the Human Insuin Promoter in HEP G2 Human Hepatoma Cells
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Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells.
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Infant diets and type 1 diabetes: too early, too late, or just too complicated?
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Infant Diets and Type 1 Diabetes: Too Early, Too Late, or Just Too Complicated?
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Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
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Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liver.
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The Second Murine Autoantibody Workshop: Remarkable Inter-laboratory Concordance for Radiobinding Assays to Identify Insulin Autoantibodies in Non-Obese Diabetic Mice
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The second murine autoantibody workshop: remarkable interlaboratory concordance for radiobinding assays to identify insulin autoantibodies in nonobese diabetic mice.
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Type 1 diabetes alters anti-hsp90 autoantibody isotype.
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Why can’t we prevent type 1 diabetes?: maybe it’s time to try a different combination.
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Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.
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Fatal attraction: chemokines and type 1 diabetes.
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Heat Shock Protein Therapy Fails to Prevent Diabetes in NOD Mice
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Heat shock protein therapy fails to prevent diabetes in NOD mice.
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International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice.
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Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector.
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A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice.
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Adeno-Associated Virus (AAV) as a Vehicle for Therapeutic Gene Delivery: Improvements in Vector Design and Viral Production Enhance Potential to Prolong Graft Survival in Pancreatic Islet Cell Transplantation for the Reversal of Type 1 Diabetes
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Adeno-associated virus (AAV) as a vehicle for therapeutic gene delivery: improvements in vector design and viral production enhance potential to prolong graft survival in pancreatic islet cell transplantation for the reversal of type 1 diabetes.
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Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
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Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes.
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Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors.
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Ingested IFN-Alpha Preserves Residual Beta Cell Function in Type 1 Diabetes
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International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: Identification of Insulin but not Glutamic Acid Decarboxylase or IA-2 as Specific Autoantigens of Humoral Autoimmunity in Nonobese Diabetic Mice
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Prediction of Diabetes and Response to Therapy in Individual Animals: Are There Lessons for Man?
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Proposed guidelines on screening for risk of type 1 diabetes.
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Type 1 diabetes: new perspectives on disease pathogenesis and treatment.
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Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.
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Azathioprine associated T-cell mutations in insulin-dependent diabetes mellitus.
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Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in Beta Cells
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T-cell markers in Type 1 Diabetes: Progress, Prospects and Realistic Expectations
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The $64000 question in diabetes continues..
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Autoantigens IA-2 and GAD in Type 1 (Insulin Dependent) Diabetes
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