Mark A Atkinson

Mark A Atkinson,

Eminent Scholar

Department: MD-PATHOLOGY
Business Phone: (352) 273-8276
Business Email: atkinson@ufl.edu

About Mark A Atkinson

Dr. Atkinson is currently the American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida. He also is the Director of the Diabetes Institute at UF. The author of nearly 600 publications, Dr. Atkinson is beginning his 37th year of investigation into the field of type 1 diabetes. Dr. Atkinson has been the recipient of multiple scientific and humanitarian based awards for these efforts. Those include each of the three from the Juvenile Diabetes Research Foundation (JDRF). The first was the Gerold and Gayla Grodsky award (2001) provided to the outstanding Ph.D. investigating type 1 diabetes. He is a three-time recipient of the Mary Tyler Moore & S. Robert Levine M.D. award for translational research on type 1 diabetes (2004, 2008, and 2014). He was also the recipient of the JDRF’s David Rumbough award for contributions to diabetes research (2005) and the prestigious Eli Lilly Award for Outstanding Scientific Achievement from the American Diabetes Association (ADA) (2004). He also received the Barbara Davis Award for contributions to the field seeking to prevent type 1 diabetes (2015), the Claes Hellerström Award (Sweden) for his efforts promoting pancreas research in this disease (2016), and the 2016 recipient of the outstanding alumni award from his alma mater (The University of Michigan-Dearborn). Most recently, he received the UF College of Medicine Lifetime Achievement Award (2018), the ADA Humanitarian Award (2018) and the ADA Albert Renold Award (2018), College of Medicine Wall of Fame Award (2019), and the Jacobaeus Award from the Novo Nordisk Foundation (2019; the most prestigious international award in Endocrinology and Metabolism). He has also engaged in leadership service to the type 1 diabetes community, with active administrative or advisory service to JDRF, The American Diabetes Association (ADA), The National Institutes of Health, The Immunology of Diabetes Society, and a variety of companies from the pharmaceutical and biotech industry. At present, this includes service as the Executive Director of the JDRF Network for Pancreatic Organ donors with Diabetes (nPOD) program, and he recently completed his term as Steering Committee Chair of the NIH Human Islet Research Network (HIRN); both organizations are directed at major questions in type 1 diabetes with international recognition and impact. He is also a long-standing member of the NIH TrialNet effort, having served in a number of leadership capacities with that organization since its inception. Dr. Atkinson is also one of nine members of the Brehm Coalition for Type 1 Diabetes Research, as well as one of four initial members of the Leona M. and Harry B. Helmsley Charitable Trust’s Type 1 Diabetes Research Initiative. He has served on the state, regional, as well as the national Board of Directors for the ADA, as well as past-memberships on their publications, scientific sessions planning, research review committees. He recently completed service as an Associate Editor of the ADA’s Journal Diabetes and now serves as ad hoc Editor-in-Chief of that journal as well as Diabetes Care. Dr. Atkinson is an internationally recognized authority on multiple aspects pertaining to type 1 diabetes, with particular interests in disease prediction and prevention, the role for environment in the initiation of the disease, stem cells and pancreatic regeneration, the use of animal models in studies of type 1 diabetes pathogenesis and therapy, and the identification of markers of tolerance and immunoregulation. In 2019, Dr. Atkinson surpassed $75M in total extramural funding for his career. With respect to the notions of prevention and cure of type 1 diabetes, Dr. Atkinson has extensively contributed to the performance of some seven “bench to bedside” trials. He has been active in terms of training and education of the next generation of diabetes researchers in many ways throughout his career, including service (two terms) on the NIH NIDDK Training Study Section, undertaking/publishing a 30 year research study on the effectiveness of JDRF training programs, as well as personal mentoring to over 30 graduate students/post-doctoral fellows/clinical fellows/young faculty (K awardees). Dr. Atkinson has been the recipient of numerous funding awards. Finally, he is President of Insulin for Life USA, the world’s second largest charity dedicated to providing insulin to persons living with diabetes in the developing world.

Teaching Profile

Courses Taught
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation

Research Profile

When a first year graduate student at The University of Florida in 1984, my Mentor provided words of advice that remain a major part of my academic life. In a conversation regarding what areas would form the best focus for a research career in T1D, he responded, “If you pursue three avenues of investigation and find out their answers, you will make a valuable contribution to type 1 diabetes (sic)”. Those recommended efforts were to: • Determine what causes type 1 diabetes. • Identify a means to predict, months to years in advance, who will develop the disease. • Develop a method to cure type 1 diabetes.

Now some 35 years later, with both a sense of happiness and sadness, I can say that these three avenues remain a major focus of my research efforts. Happiness, in that progress has been made by the research community (with some contributions from my research group and collaborators) towards each goal, but at the same time none have been fully addressed. Indeed, progress towards each goal differs quite dramatically. For example, we and others have, to a large extent, developed a means to predict in a population of individuals who is likely to develop T1D. This is a major (if even partial) success. At the same time, its impact remains somewhat muted in that without an answer to the third goal (a method to prevent or cure the disease), efforts for disease prediction have been somewhat underutilized by the public health care community. That said, we are moving closer (and leading efforts) towards testing of agents capable of effectively intervening in the disease which leaves open the discussion of progress towards the first goal, understanding what causes the disorder. Sadly, of all the goals, this one remains the most elusive. Perhaps in part because of this state of progress, I have expanded my efforts to seeing insulin provided to those in third world areas as while not a cure, it does represent a life-saving entity.

Areas of Interest
  • type 1 diabetes, pancreatic pathology, immune therapy, autoimmunity, clinical trials, translational research, emerging technologies, psychosocial behaviors, metabolism
Open Researcher and Contributor ID (ORCID)

0000-0001-8489-4782

Publications

2022
A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America. [DOI] 10.1073/pnas.2120028119. [PMID] 35878027.
2022
Erratum. The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes 2021;70:1623-1633.
Diabetes. [DOI] 10.2337/db22-er06a. [PMID] 35380651.
2022
Erratum. The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes Care 2021;44:1734-1743.
Diabetes care. [DOI] 10.2337/dc22-er06b. [PMID] 35380617.
2022
Exploration of autoantibody responses in canine diabetes using protein arrays.
Scientific reports. [DOI] 10.1038/s41598-022-06599-5. [PMID] 35169238.
2022
Improving the Prediction of Type 1 Diabetes Across Ancestries.
Diabetes care. [DOI] 10.2337/dc21-1254. [PMID] 35043156.
2022
Limited extent and consequences of pancreatic SARS-CoV-2 infection.
Cell reports. [DOI] 10.1016/j.celrep.2022.110508. [PMID] 35247306.
2022
Response to Comment on Dunne et al. The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes Care 2021;44:1734-1743.
Diabetes care. [DOI] 10.2337/dci21-0055. [PMID] 35561137.
2022
The pathogenesis, natural history, and treatment of type 1 diabetes: time (thankfully) does not stand still.
The lancet. Diabetes & endocrinology. [DOI] 10.1016/S2213-8587(21)00344-2. [PMID] 34951951.
2022
α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals.
The Journal of clinical investigation. [DOI] 10.1172/JCI156243. [PMID] 35642629.
2021
ACE2 chromogenic immunostaining protocol optimized for formalin-fixed paraffin-embedded human tissue sections.
STAR protocols. [DOI] 10.1016/j.xpro.2021.100696. [PMID] 34308375.
2021
Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes
Diabetologia. [DOI] 10.1007/s00125-021-05501-8. [PMID] 34274990.
2021
Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes
Diabetes. [DOI] 10.2337/dbi20-0034. [PMID] 33947721.
2021
Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Sudan.
Pediatric diabetes. [DOI] 10.1111/pedi.13209. [PMID] 33837995.
2021
Correction to: Targeted metabolomic analysis identifies increased serum levels of GABA and branched chain amino acids in canine diabetes.
Metabolomics : Official journal of the Metabolomic Society. [DOI] 10.1007/s11306-021-01865-5. [PMID] 34923611.
2021
Defining a cure for type 1 diabetes: a call to action.
The lancet. Diabetes & endocrinology. [DOI] 10.1016/S2213-8587(21)00181-9. [PMID] 34339632.
2021
Delayed diagnosis of diabetic ketoacidosis and associated mortality during the COVID-19 pandemic.
Journal of diabetes. [DOI] 10.1111/1753-0407.13208. [PMID] 34196115.
2021
Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes?
The lancet. Diabetes & endocrinology. [DOI] 10.1016/S2213-8587(21)00087-5. [PMID] 33838106.
2021
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size
Diabetes. [DOI] 10.2337/db20-0995. [PMID] 33441381.
2021
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature genetics. [DOI] 10.1038/s41588-021-00880-5. [PMID] 34127860.
2021
geneBasis: an iterative approach for unsupervised selection of targeted gene panels from scRNA-seq.
Genome biology. [DOI] 10.1186/s13059-021-02548-z. [PMID] 34872616.
2021
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.
Diabetes. [DOI] 10.2337/db20-0937. [PMID] 33419759.
2021
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America. [DOI] 10.1073/pnas.2107208118. [PMID] 34611019.
2021
Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas
The American Journal of Pathology. [DOI] 10.1016/j.ajpath.2020.11.010. [PMID] 33307036.
2021
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study.
Science immunology. [DOI] 10.1126/sciimmunol.abf3733. [PMID] 34376480.
2021
Index60 as an additional diagnostic criterion for type 1 diabetes.
Diabetologia. [DOI] 10.1007/s00125-020-05365-4. [PMID] 33496819.
2021
Insulin Receptor–Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice
The Journal of Immunology. [DOI] 10.4049/jimmunol.1900357. [PMID] 33658296.
2021
Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.
Genome biology. [DOI] 10.1186/s13059-021-02262-w. [PMID] 33478573.
2021
Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation.
Cell reports. [DOI] 10.1016/j.celrep.2021.108725. [PMID] 33535031.
2021
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.
Scientific reports. [DOI] 10.1038/s41598-021-85659-8. [PMID] 33753784.
2021
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report
Diabetes. [DOI] 10.2337/db20-1103. [PMID] 33632742.
2021
Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes.
Diabetes. [DOI] 10.2337/dbi20-0026. [PMID] 33472941.
2021
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes
Diabetes. [DOI] 10.2337/db21-0070. [PMID] 34035041.
2021
Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices.
Journal of visualized experiments : JoVE. [DOI] 10.3791/62207. [PMID] 33900291.
2021
Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation.
Journal of immunology (Baltimore, Md. : 1950). [DOI] 10.4049/jimmunol.2000708. [PMID] 34301848.
2021
Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes.
Diabetologia. [DOI] 10.1007/s00125-021-05468-6. [PMID] 34003304.
2021
Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors.
Frontiers in endocrinology. [DOI] 10.3389/fendo.2021.622647. [PMID] 33841327.
2021
Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry.
Cell reports. [DOI] 10.1016/j.celrep.2021.109919. [PMID] 34731614.
2021
Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies.
Frontiers in endocrinology. [DOI] 10.3389/fendo.2021.778912. [PMID] 34912300.
2021
Targeted metabolomic analysis identifies increased serum levels of GABA and branched chain amino acids in canine diabetes.
Metabolomics : Official journal of the Metabolomic Society. [DOI] 10.1007/s11306-021-01850-y. [PMID] 34775536.
2021
TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes.
Cell. [DOI] 10.1016/j.cell.2020.11.035. [PMID] 33545036.
2021
The influence of selection bias on identifying an association between allergy medication use and SARS-CoV-2 infection.
EClinicalMedicine. [DOI] 10.1016/j.eclinm.2021.100936. [PMID] 34104879.
2021
The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence.
Diabetes. [DOI] 10.2337/db21-0052. [PMID] 35381061.
2021
The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence
Diabetes Care. [DOI] 10.2337/dci21-0015.
2021
Time to Peak Glucose and Peak C-Peptide During the Progression to Type 1 Diabetes in the Diabetes Prevention Trial and TrialNet Cohorts.
Diabetes care. [DOI] 10.2337/dc21-0226. [PMID] 34362815.
2021
Voices: Insulin and beyond.
Cell metabolism. [DOI] 10.1016/j.cmet.2021.03.017. [PMID] 33826910.
2020
An Intolerable Burden: Suicide, Intended Self-Injury and Diabetes.
Canadian journal of diabetes. [DOI] 10.1016/j.jcjd.2020.01.008. [PMID] 32305294.
2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology. [DOI] 10.3389/fimmu.2020.02180. [PMID] 33013915.
2020
Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S.
Diabetes Care. [DOI] 10.2337/dc19-1941. [PMID] 32273273.
2020
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics. [DOI] 10.1089/dia.2020.0305. [PMID] 32833543.
2020
Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics.
Metabolites. [DOI] 10.3390/metabo10090350. [PMID] 32867274.
2020
Early and late C-peptide responses during oral glucose tolerance testing are oppositely predictive of type 1 diabetes in autoantibody-positive individuals.
Diabetes, obesity & metabolism. [DOI] 10.1111/dom.13982. [PMID] 32003110.
2020
Erratum. Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention. Diabetes Care 2019;42:2228-2236.
Diabetes care. [DOI] 10.2337/dc20-er04. [PMID] 32132004.
2020
Evaluation for type 1 diabetes associated autoantibodies in diabetic and non-diabetic Australian terriers and Samoyeds.
Canine medicine and genetics. [DOI] 10.1186/s40575-020-00089-5. [PMID] 33323126.
2020
Exocrine Pancreas Dysfunction in Type 1 Diabetes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. [DOI] 10.4158/EP-2020-0295. [PMID] 33471743.
2020
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Cell metabolism. [DOI] 10.1016/j.cmet.2020.11.005. [PMID] 33207244.
2020
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association. [DOI] 10.1111/dme.14361. [PMID] 32634859.
2020
Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.
Frontiers in immunology. [DOI] 10.3389/fimmu.2020.574447. [PMID] 33193362.
2020
Innate inflammation drives NK cell activation to impair Treg activity
Journal of Autoimmunity. [DOI] 10.1016/j.jaut.2020.102417. [PMID] 32035746.
2020
Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis
Diabetes. [DOI] 10.2337/db19-0942. [PMID] 31826866.
2020
Intestinal Delivery of Proinsulin and IL-10 via Lactococcus lactis Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis.
Frontiers in immunology. [DOI] 10.3389/fimmu.2020.01103. [PMID] 32582188.
2020
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Diabetes care. [DOI] 10.2337/dc19-0880. [PMID] 31753960.
2020
Large-scale electron microscopy database for human type 1 diabetes.
Nature communications. [DOI] 10.1038/s41467-020-16287-5. [PMID] 32424134.
2020
Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
Nature Communications. [DOI] 10.1038/s41467-020-17040-8. [PMID] 32601271.
2020
Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells.
JCI insight. [DOI] 10.1172/jci.insight.136579. [PMID] 32573495.
2020
Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions.
JAMA pediatrics. [DOI] 10.1001/jamapediatrics.2020.0085. [PMID] 32202626.
2020
Organisation of the human pancreas in health and in diabetes
Diabetologia. [DOI] 10.1007/s00125-020-05203-7. [PMID] 32894306.
2020
Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis.
JCI insight. [DOI] 10.1172/jci.insight.134525. [PMID] 32324170.
2020
Pancreatlas: Applying an Adaptable Framework to Map the Human Pancreas in Health and Disease.
Patterns (New York, N.Y.). [DOI] 10.1016/j.patter.2020.100120. [PMID] 33294866.
2020
Publisher Correction: Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
Nature Communications. [DOI] 10.1038/s41467-020-17574-x. [PMID] 32699243.
2020
Removing Formaldehyde‐Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin‐Fixed Paraffin‐Embedded Tissues
Angewandte Chemie International Edition. [DOI] 10.1002/anie.202008847.
2020
Removing Formaldehyde‐Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin‐Fixed Paraffin‐Embedded Tissues
Angewandte Chemie. [DOI] 10.1002/ange.202008847.
2020
Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance.
The Journal of clinical endocrinology and metabolism. [DOI] 10.1210/clinem/dgz296. [PMID] 31867614.
2020
Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis
Scientific Reports. [DOI] 10.1038/s41598-019-56951-5. [PMID] 31959869.
2020
Teaching Type 1 Diabetes: Creating Stakeholder Engagement in Biomedical Careers Through Undergraduate Research Curriculum
Medical Science Educator. [DOI] 10.1007/s40670-019-00877-0. [PMID] 34457640.
2020
Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues
Diabetes. [DOI] 10.2337/db19-0554. [PMID] 31597639.
2020
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.
Diabetologia. [DOI] 10.1007/s00125-019-05047-w. [PMID] 31768570.
2019
A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.
Cell metabolism. [DOI] 10.1016/j.cmet.2018.11.014. [PMID] 30713109.
2019
Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.
Analytical chemistry. [DOI] 10.1021/acs.analchem.9b00024. [PMID] 30843680.
2019
Bringing closure: towards achieving a better understanding of Israel.
Lancet (London, England). [DOI] 10.1016/S0140-6736(19)31760-X. [PMID] 31376991.
2019
Clinical features, biochemistry and HLA-DRB1 status in children and adolescents with diabetes in Dhaka, Bangladesh
Diabetes Research and Clinical Practice. [DOI] 10.1016/j.diabres.2019.107894. [PMID] 31669629.
2019
Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan
Diabetes Research and Clinical Practice. [DOI] 10.1016/j.diabres.2019.01.023. [PMID] 30710658.
2019
Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.
ACS biomaterials science & engineering. [DOI] 10.1021/acsbiomaterials.9b00332. [PMID] 31119191.
2019
Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
Nature Communications. [DOI] 10.1038/s41467-019-11460-x. [PMID] 31399563.
2019
Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene.
Scientific reports. [DOI] 10.1038/s41598-019-38905-z. [PMID] 30862859.
2019
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.
Cell reports. [DOI] 10.1016/j.celrep.2019.11.010. [PMID] 31801074.
2019
Islet amyloidosis in a child with type 1 diabetes
Islets. [DOI] 10.1080/19382014.2019.1599707. [PMID] 31084520.
2019
Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes
Journal of Histochemistry & Cytochemistry. [DOI] 10.1369/0022155418778546. [PMID] 29771178.
2019
Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].
Diabetologia. [DOI] 10.1007/s00125-019-4873-6. [PMID] 31016358.
2019
Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data
Diabetes. [DOI] 10.2337/db19-0057. [PMID] 30967424.
2019
Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.
Cell metabolism. [DOI] 10.1016/j.cmet.2019.01.003. [PMID] 30713110.
2019
NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP).
Diabetes. [DOI] 10.2337/db19-0058. [PMID] 31127054.
2019
Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity. [DOI] 10.1097/MED.0000000000000484. [PMID] 31145130.
2019
Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.
Diabetologia. [DOI] 10.1007/s00125-019-4811-7. [PMID] 30675626.
2019
Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.
Journal of clinical medicine. [DOI] 10.3390/jcm8091321. [PMID] 31466263.
2019
Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes
Diabetes Care. [DOI] 10.2337/dc18-1512. [PMID] 30552130.
2019
Research digest: pioneering an oral GLP-1 receptor agonist.
The lancet. Diabetes & endocrinology. [DOI] 10.1016/S2213-8587(19)30360-2. [PMID] 31748168.
2019
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
Cell Metabolism. [DOI] 10.1016/j.cmet.2019.01.021. [PMID] 30799288.
2019
The challenge of modulating β-cell autoimmunity in type 1 diabetes.
The lancet. Diabetes & endocrinology. [DOI] 10.1016/S2213-8587(18)30112-8. [PMID] 30528099.
2019
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program.
Nature. [DOI] 10.1038/s41586-019-1629-x. [PMID] 31597973.
2019
The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.
Diabetes care. [DOI] 10.2337/dc19-0102. [PMID] 31167894.
2019
Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.
Diabetes care. [DOI] 10.2337/dc18-1727. [PMID] 30659077.
2019
Untargeted metabolomic analysis in non-fasted diabetic dogs by UHPLC-HRMS.
Metabolomics : Official journal of the Metabolomic Society. [DOI] 10.1007/s11306-019-1477-6. [PMID] 30830416.
2019
Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention.
Diabetes care. [DOI] 10.2337/dc19-0593. [PMID] 31558546.
2018
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
Cell Reports. [DOI] 10.1016/j.celrep.2018.02.032. [PMID] 29514095.
2018
A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
Diabetes care. [DOI] 10.2337/dc18-0087. [PMID] 30002199.
2018
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
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2018
Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.
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Epidemiology of childhood-onset type 1 diabetes in Azerbaijan: Incidence, clinical features, biochemistry, and HLA-DRB1 status.
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Hospital time prior to death and pancreas histopathology: implications for future studies.
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Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes.
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Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles
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2018
Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes.
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2018
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Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes—The TrialNet Experience
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Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.
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Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes
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β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?
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Beta cell mass versus function in type 1 diabetes: truth or dare?
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Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?
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Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials
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Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
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High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes
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Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.
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Raising Awareness: The Need to Promote Allocation of Pancreata From Rare Nondiabetic Donors With Pancreatic Islet Autoimmunity to Type 1 Diabetes Research.
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Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?
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Re-addressing the 2013 consensus guidelines for the diagnosis of insulits in human type 1 diabetes – Is change necessary?
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Tracking the Antibody Immunome in Type 1 Diabetes Using Protein Arrays
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2016
A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.
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An Interview with Dr. Mark Atkinson on 100 Years of Type 1 Diabetes Care and Research
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Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
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Towards a Functional Hypothesis Relating Anti-Islet Autoimmunity to the Dietary Impact on Microbial Communities and Butyrate Production
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A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.
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A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.
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Hla-Associated Susceptibility To Type 1 Diabetes in the Developing World Reveals Differences Among Populations; Implications for Prediction and Intervention
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Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. [DOI] 10.1111/ajt.12333. [PMID] 23834659.
2013
Trying to make a difference for those with Type 1 Diabetes: a lesson in patience as well as a willingness to fail mightily
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2013
Trying to make a difference for those with Type 1 diabetes: a lesson in patience as well as a willingness to fail mightily.
Expert review of endocrinology & metabolism. [DOI] 10.1586/17446651.2013.811869. [PMID] 30736146.
2013
γ-Aminobutyric acid regulates both the survival and replication of human β-cells.
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2012
Anti-Thymocyte Globulin (Atg) Differentially Depletes Naive and Memory T Cells and Permits Memory-Type Regulatory T Cells
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Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.
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2012
Central role for interleukin-2 in type 1 diabetes.
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2012
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2012
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.
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2012
Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease.
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2012
Formation of a human β-cell population within pancreatic islets is set early in life.
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2012
In Vitro Generation of Functional Insulin-Producing Cells from Human Bone Marrow-Derived Stem Cells, but Long-Term Culture Running Risk of Malignant Transformation
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In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation.
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2012
Mixed Chimerism and Growth Factors Augment Beta Cell Regeneration and Reverse Late-Stage Type 1 Diabetes
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Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.
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No increased rate of acute myocardial infarction or stroke among patients with ankylosing spondylitis-a retrospective cohort study using routine data.
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On the Road To the Insulin Centenary
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Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.
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Serum levels of soluble CD25 as a marker for hepatocellular carcinoma.
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The pathogenesis and natural history of type 1 diabetes.
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The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice.
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Tyrphostin Ag490 Agent Modestly But Significantly Prevents Onset of Type 1 in Nod Mouse; Implication of Immunologic and Metabolic Effects of a Jak-Stat Pathway Inhibitor
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2011
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
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2011
Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide.
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2011
B cells enhance early innate immune responses during bacterial sepsis.
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Combinatorial treatment of bone marrow stem cells and stromal cell-derived factor 1 improves glycemia and insulin production in diabetic mice.
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Evaluating preclinical efficacy.
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Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.
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How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.
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2011
Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice.
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Immune Modulation in Early Onset Pompe Disease
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Induction of Mixed Chimerism With Mhc-Mismatched But Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in Nod Mice
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2011
Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.
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It’s time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes.
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2011
It’s time to mow the GRAS in type 1 diabetes.
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2011
Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies.
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2011
Mesenchymal Stem Cells Express Serine Protease Inhibitor To Evade the Host Immune Response
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Microbiology of Type 1 Diabetes: Possible Implications for Management of the Disease
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Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes.
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Persistence is the twin sister of excellence: an important lesson for attempts to prevent and reverse type 1 diabetes.
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2011
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.
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2011
Rapamycin Combined With Anti-Cd45Rb Mab and Il-10 Or With G-Csf Induces Tolerance in a Stringent Mouse Model of Islet Transplantation
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2011
Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.
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2011
Stem Cell Therapy of Diabetes: Effective Treatment with Stromal Cell-Derived Factor 1 plus Bone Marrow Stem Cells in the Liver of Diabetic Mice
Molecular and Cellular Endocrinology.
2011
Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.
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The Novel Role of Serpinb9 in Cytotoxic Protection of Human Mesenchymal Stem Cells
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2011
The pancreas in human type 1 diabetes.
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2011
The threshold hypothesis: solving the equation of nurture vs nature in type 1 diabetes.
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Toward Defining the Autoimmune Microbiome for Type 1 Diabetes
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Toward defining the autoimmune microbiome for type 1 diabetes.
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2010
A model for studying the impact of nurture on nature: Development of diabetes in multicongenic mice with an epigenetic gene expression dysregulation defect from the nonobese diabetic mouse (NOD)
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A Novel Clinically Relevant Strategy To Abrogate Autoimmunity and Regulate Alloimmunity in Nod Mice
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2010
Antigen-Specific Dependence of Tr1-Cell Therapy in Preclinical Models of Islet Transplant
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Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
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Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes
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2010
Developing Combination Immunotherapies for Type 1 Diabetes: Recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
Clinical and Experimental Immunology.
2010
Dimorphic Histopathology of Long Standing Childhood Onset Diabetes
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Dimorphic histopathology of long-standing childhood-onset diabetes.
Diabetologia. [DOI] 10.1007/s00125-009-1642-y. [PMID] 20062967.
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Efforts to prevent and halt autoimmune beta cell destruction.
Endocrinology and metabolism clinics of North America. [DOI] 10.1016/j.ecl.2010.05.006. [PMID] 20723818.
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Estimating the Cost of Type 1 Diabetes in the Us: a Propensity Score Matching Method
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Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.
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Genetic Control of B-Cell Mass Homeostasis
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Hepatocellular carcinoma immunopathogenesis: clinical evidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25).
Digestive diseases and sciences. [DOI] 10.1007/s10620-009-0955-5. [PMID] 19714465.
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Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
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Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver Or Pancreas To Reverse Refractory Autoimmune Diabetes
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2010
Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver or Pancreas to Reverse Refractory Autoimmune Disease
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2010
Influence of Serum and CD25 Stability on Regulatory T cell Activity: Implications for Immune Regulation
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Influence of serum and soluble CD25 (sCD25) on regulatory and effector T-cell function in hepatocellular carcinoma.
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Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Diabetologia. [DOI] 10.1007/s00125-010-1829-2. [PMID] 20593162.
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Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
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The Juvenile Diabetes Research Foundation at forty: updates of research in type 1 diabetes.
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The Type 1 Diabetes PhysioLab® Platform: A Validated Physiologically Based Mathematical Model of Pathogenesis in the Non-Obese Diabetic Mouse
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Amelioration of Insulitis and Reversal of Diabetes in Nod Mice By Murine Anti-Thymocyte Globulin and Granulocyte-Colony Stimulating Factor Combination Therapy
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2009
Anti-Mouse Thymocyte Globulin Administration Alters Dendritic Cell Profile and Function in Nod Mice To Suppress Diabetogenic Responses.
American Journal of Transplantation.
2009
Autologous umbilical cord blood transfusion in very young children with type 1 diabetes.
Diabetes care. [DOI] 10.2337/dc09-0967. [PMID] 19875605.
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Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model.
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Deaf1 Isoforms Control the Expression of Genes Encoding Peripheral Tissue Antigens in the Pancreatic Lymph Nodes During Type 1 Diabetes
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Diabetic eNOS Knockout Mice Develop Accelerated Retinopathy
Investigative Ophthalmology & Visual Science.
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Expansion of human regulatory T-cells from patients with type 1 diabetes.
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Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
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Immunomodulatory Function of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Type 1 Diabetes
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Influence of Fecal Sample Storage on Bacterial Community Diversity
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Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
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Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
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Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation.
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Network for Pancreatic Organ Donors With Diabetes (Npod): Donor Demographics and Early Progress Report
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Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.
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Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
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Rapamycin Prevents and Breaks the Anti-Cd3-Induced Tolerance in Nod Mice
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T regulatory cell function in idiopathic minimal lesion nephrotic syndrome.
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Taking a daily vitamin to prevent type 1 diabetes?
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The pancreas in human type 1 diabetes: providing new answers to age-old questions.
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The road not taken: a path to curing type 1 diabetes?
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A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
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A Prophylactic Protocol for the Prevention of Inhibitor Formation in Gene Therapy for Hemophilia B By Shifting the Balance From An Effector To a Regulatory T Cell Response
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Addressing ceiling effects in health status measures: a comparison of techniques applied to measures for people with HIV disease.
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CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.
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Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic Nod Mice
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Comparative analysis of the islet proteome between NOD/Lt and ALR/Lt mice.
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Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
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Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice.
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Immunomodulation By Mesenchymal Stem Cells – a Potential Therapeutic Strategy for Type 1 Diabetes
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Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
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Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.
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Prolonged islet allograft survival by alpha-1 antitrypsin: the role of humoral immunity.
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Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy.
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Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.
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The “perfect storm” for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.
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The IDS Conducts Standardization of Assays for the Measurement of Autoantibodies and of T Cells in Autoimmune Diabetes
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The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.
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Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.
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Alpha-1 antitrypsin treatment of spontaneously diabetic NOD mice receiving islet allografts
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Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?
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Assessing the in Vitro Suppressive Capacity of Regulatory T Cells
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Assessing the in vitro suppressive capacity of regulatory T cells.
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Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11.
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Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
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Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.
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Elimination of Insulitis and Augmentation of Islet β Cell Regeneration Via Induction of Chimerism in Overtly Diabetic NOD Mice
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Large-Scale Genetic Fine Mapping and Genotype-Phenotype Associations Implicate Polymorphism in the IL2RA Region in Type 1 Diabetes
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Mechanisms of PDL1-Mediated Regulation of Autoimmune Diabetes
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No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes.
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Novel synthesis of cerium oxide nanoparticles for free radical scavenging.
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The Virtual NOD Mouse: Applying Predictive Biosimulation to Research in Type 1 Diabetes
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The virtual NOD mouse: applying predictive biosimulation to research in type 1 diabetes.
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Treg in Type 1 Diabetes
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Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
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Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
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Efficient Delivery of siRNA into Cytokine-Stimulated Insulinoma Cells Silences Fas Expression and Inhibits Fas-Mediated Apoptosis
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Efficient delivery of siRNA into cytokine-stimulated insulinoma cells silences Fas expression and inhibits Fas-mediated apoptosis.
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Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice.
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Freeze-Thaw Increases Adeno-Associated Virus Transduction of Cells
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IL-10 regulation of lupus in the NZM2410 murine model.
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Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
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Long-term Monitoring of Transplanted Islets Using Positron Emission Tomography
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Noninvasive imaging of islet grafts using positron-emission tomography.
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Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.
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Laboratory investigation; a journal of technical methods and pathology. [PMID] 16732298.
2006
Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy.
Journal of the American Society of Nephrology : JASN. [PMID] 16436494.
2005
9th Annual EASD/JDRF Oxford Workshop Mechanisms and Prevention of Type 1 Diabetes
.
2005
A comprehensive review of interventions in the NOD mouse and implications for translation.
Immunity. [PMID] 16111631.
2005
ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can’t we prevent or reverse this disease?
Diabetes. [PMID] 15855308.
2005
An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells
Journal of Immunology. [DOI] 10.4049/jimmunol.174.9.5181. [PMID] 15843512.
2005
An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950). [PMID] 15843512.
2005
Autoimmunity to Glutamic Acid Decarboxylase in the Neurodegenerative Disorder Batten Disease
.
2005
Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice.
Brain research. [PMID] 15829231.
2005
Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.
Journal of pediatric gastroenterology and nutrition. [PMID] 15861021.
2005
Chronic Inflammatory Demyelinating Polyradiculoneuropathy in Two Children with Type 1 Diabetes Mellitus
Pediatric Diabetes.
2005
Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.
Journal of virology. [PMID] 15613333.
2005
Donor CD8+ T Cells Facilitate Induction of Chimerism and Tolerance Without GVHD in Autoimmune NOD Mice Conditioned with Anti-CD3 mAb
Blood.
2005
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Human gene therapy. [PMID] 15761263.
2005
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
Diabetes. [PMID] 15855327.
2005
Gene Therapy for Prevention and Treatment of Type 1 Diabetes
Laboratory Techniques in Biochemistry and Molecular Biology.
2005
Glucose Transporter-2 (GLUT2) Promoter Mediated Transgenic Insulin Production Reduces Hyperglycemia in Diabetic Mice
.
2005
Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice.
FEBS letters. [PMID] 16223491.
2005
High Frequency of Abnormal Glucose Tolerance in DQA1*02/DQB1*0602 Relatives Identified as Part of the Diabetes Prevention Trial–Type 1 Diabetes
.
2005
IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease.
Journal of the American Society of Nephrology : JASN. [PMID] 16251240.
2005
Impact of humoral immune response on distribution and efficacy of recombinant adeno-associated virus-derived acid alpha-glucosidase in a model of glycogen storage disease type II.
Human gene therapy. [PMID] 15703490.
2005
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America. [PMID] 15878989.
2005
Islet cell autoantibodies: a case of a premature obituary.
Pediatric diabetes. [PMID] 16390385.
2005
Lessons from attempts to prevent type 1 diabetes—potential implications for type 2 diabetes
.
2005
Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
Molecular therapy : the journal of the American Society of Gene Therapy. [PMID] 15979413.
2005
Neonatal Nutritional Interventions in the Prevention of Type 1 Diabetes
.
2005
Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.
Journal of immunology (Baltimore, Md. : 1950). [PMID] 16177100.
2005
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis.
Diabetes. [PMID] 16123339.
2005
Pancreatic regeneration in type 1 diabetes: dreams on a deserted islet?
Diabetologia. [PMID] 16193285.
2005
SUMO Wrestling with Type 1 Diabetes
Molecular Therapy.
2005
SUMO wrestling with type 1 diabetes.
Journal of molecular medicine (Berlin, Germany). [PMID] 15806321.
2005
Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect eveidence for islet regeneration? Commentary
.
2005
Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.
Transplantation. [PMID] 16123729.
2005
Type 1 diabetes mellitus: etiology, presentation, and management.
Pediatric clinics of North America. [PMID] 16301083.
2005
Viruses and Diabetes-Reply
Diabetic Medicine.
2004
A Functional Variant of SUM04, a New I Kappa B Alpha Modifier, is Associated with Type 1 Diabetes
Nature Genetics.
2004
A Piece of Nucleic Acid Surrounded By Controversy: Coxsackieviruses and the Causes of Type 1 Diabetes
Diabetic Medicine.
2004
Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes.
Diabetes care. [PMID] 15277432.
2004
Animal Models Have Little to Teach Us About Type 1 Diabetes
.
2004
Assessing the quality of immunoassay systems: Radioimmunoassays and enzyme, fluorescence, and luminescence immunoassays; approved guideline
.
2004
Bioluminescent Monitoring of Islet Graft Survival After Transplantation
.
2004
Bioluminescent monitoring of islet graft survival after transplantation.
Molecular therapy : the journal of the American Society of Gene Therapy. [PMID] 15006610.
2004
Evaluation of the size and type of free particulates collected from unused asbestos-containing brake components as related to potential for respirability.
American journal of industrial medicine. [PMID] 15551364.
2004
Gene Therapy for Type 1 Diabetes: Metabolism, Immunity, Islet Cell Preservation and Regeneration
.
2004
Glutamic Acid Decarboxylase Autoimmunity in Batten Disease and Other Disorders
.
2004
Glutamic acid decarboxylase autoimmunity in Batten disease and other disorders.
Neurology. [PMID] 15596740.
2004
Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.
The American journal of pathology. [PMID] 15331427.
2004
Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity.
Gene therapy. [PMID] 14737082.
2004
In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow.
Diabetes. [PMID] 15220196.
2004
Presence of Diabetes-Inhibiting, Glutamic Acid Decarboxylase-Specific IL-10-Dependent Regulatory T Cells in Naïve Non-Obese Diabetic Mice
Journal of Immunology.
2004
Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus–a new surrogate measure of non-progression?
Pediatric diabetes. [PMID] 15189492.
2004
Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes.
Diabetes Care. [DOI] 10.2337/diacare.27.12.2911. [PMID] 15562206.
2004
Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice.
Gene therapy. [PMID] 14712302.
2004
Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes.
Nature reviews. Immunology. [DOI] 10.1038/nri1502. [PMID] 15573133.
2004
Timing of initial cereal exposure in infancy and risk of islet autoimmunity.
The Journal of pediatrics. [PMID] 15152374.
2004
Von-Herrath.: Satisfaction (Not) Guaranteed: Re-evaluating the Use of Animal Models of Type-1 Diabetes
.
2003
Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
Pediatric diabetes. [PMID] 14655518.
2003
Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.
Diabetes. [PMID] 12606512.
2003
Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.
Journal of the American Society of Nephrology : JASN. [PMID] 12660329.
2003
Glucose-Responsive Expression of the Human Insuin Promoter in HEP G2 Human Hepatoma Cells
.
2003
Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells.
Annals of the New York Academy of Sciences. [PMID] 14679068.
2003
Infant diets and type 1 diabetes: too early, too late, or just too complicated?
JAMA. [PMID] 14519713.
2003
Infant Diets and Type 1 Diabetes: Too Early, Too Late, or Just Too Complicated?
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2003
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950). [PMID] 12928371.
2003
Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liver.
Gene therapy. [PMID] 12907946.
2003
The Second Murine Autoantibody Workshop: Remarkable Inter-laboratory Concordance for Radiobinding Assays to Identify Insulin Autoantibodies in Non-Obese Diabetic Mice
.
2003
The second murine autoantibody workshop: remarkable interlaboratory concordance for radiobinding assays to identify insulin autoantibodies in nonobese diabetic mice.
Annals of the New York Academy of Sciences. [PMID] 14679035.
2003
Type 1 diabetes alters anti-hsp90 autoantibody isotype.
Journal of autoimmunity. [PMID] 12753809.
2003
Why can’t we prevent type 1 diabetes?: maybe it’s time to try a different combination.
Diabetes care. [PMID] 14633822.
2002
Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.
Transplantation. [PMID] 12438968.
2002
Fatal attraction: chemokines and type 1 diabetes.
The Journal of clinical investigation. [PMID] 12464665.
2002
Heat Shock Protein Therapy Fails to Prevent Diabetes in NOD Mice
.
2002
Heat shock protein therapy fails to prevent diabetes in NOD mice.
Diabetologia. [PMID] 12242470.
2002
International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: Analyzing Target Autoantigens of Humoral Immunity in Non-Obese Diabetic Mice
Annals of the New York Academy of Sciences.
2002
Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector.
Molecular therapy : the journal of the American Society of Gene Therapy. [PMID] 11829522.
2001
A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950). [PMID] 11359854.
2001
Adeno-Associated Virus (AAV) as a Vehicle for Therapeutic Gene Delivery: Improvements in Vector Design and Viral Production Enhance Potential to Prolong Graft Survival in Pancreatic Islet Cell Transplantation for the Reversal of Type 1 Diabetes
.
2001
Adeno-associated virus (AAV) as a vehicle for therapeutic gene delivery: improvements in vector design and viral production enhance potential to prolong graft survival in pancreatic islet cell transplantation for the reversal of type 1 diabetes.
Current molecular medicine. [PMID] 11899074.
2001
Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America. [PMID] 11717448.
2001
Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes.
Diabetes. [PMID] 11473034.
2001
Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors.
Diabetes. [PMID] 11246870.
2001
Ingested IFN-Alpha Preserves Residual Beta Cell Function in Type 1 Diabetes
.
2001
International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: Identification of Insulin but not Glutamic Acid Decarboxylase or IA-2 as Specific Autoantigens of Humoral Autoimmunity in Nonobese Diabetic Mice
Diabetes.
2001
Prediction of Diabetes and Response to Therapy in Individual Animals: Are There Lessons for Man?
Journal of Autoimmunity.
2001
Proposed guidelines on screening for risk of type 1 diabetes.
Diabetes care. [PMID] 11213898.
2001
Type 1 diabetes: new perspectives on disease pathogenesis and treatment.
Lancet (London, England). [PMID] 11476858.
2000
Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.
Diabetes. [PMID] 10905477.
2000
Azathioprine associated T-cell mutations in insulin-dependent diabetes mellitus.
Scandinavian journal of immunology. [PMID] 10849375.
2000
Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in Beta Cells
Science.
2000
Glutamic acid decarboxylase and IA-2 autoantibodies in type 1 diabetes: comparing sample substrates for autoantibody determinations.
Pediatric diabetes. [PMID] 15016237.
2000
T-cell markers in Type 1 Diabetes: Progress, Prospects and Realistic Expectations
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2000
The $64000 question in diabetes continues..
Lancet (London, England). [PMID] 10892753.
1999
Autoantigens IA-2 and GAD in Type 1 (Insulin Dependent) Diabetes
.
1999
Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes.
Diabetologia. [PMID] 10027571.
1999
Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays.
Journal of autoimmunity. [PMID] 10479395.
1999
Cellular immune responses against proinsulin: no evidence for enhanced reactivity in individuals with IDDM.
Diabetes. [PMID] 10334305.
1999
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America. [PMID] 10393957.
1999
No Alteration in T Lymphocyte Expression of CD40 Ligand (CD154) in Individuals with or at Increased Risk for Insulin-Dependent Diabetes Mellitus
.
1999
No alteration in T lymphocyte expression of CD40 ligand (CD154) in individuals with or at increased risk for insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism. [PMID] 10566651.
1999
Selection of hprt Mutant T Cells as Surrogates for Dividing Cells Reveals a Restricted T Cell Receptor BV Repertoire in Insulin-Dependent Diabetes Mellitus
.
1999
Selection of hprt mutant T cells as surrogates for dividing cells reveals a restricted T cell receptor BV repertoire in insulin-dependent diabetes mellitus.
Clinical immunology (Orlando, Fla.). [PMID] 10075863.
1999
The NOD Mouse Model of Type 1 Diabetes Mellitus: As Good As It Gets?
.
1999
The NOD mouse model of type 1 diabetes: as good as it gets?
Nature medicine. [PMID] 10371488.
1998
Aging and the Immune Response to Tetanus Toxoid: Diminished Frequency and Level of Cellular Immune Reactivity to Antigenic Stimulation
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1998
Aging and the immune response to tetanus toxoid: diminished frequency and level of cellular immune reactivity to antigenic stimulation.
Clinical and diagnostic laboratory immunology. [PMID] 9801353.
1998
Cellular Immune Responses Against Casein: Elevated but not Specific for Individuals with Insulin Dependent Diabetes
.
1998
Cellular immune responses to beta casein: elevated in but not specific for individuals with Type I diabetes mellitus.
Diabetologia. [PMID] 9662058.
1998
Characterization of novel T-cell epitopes on 65 kDa and 67 kDa glutamic acid decarboxylase relevant in autoimmune responses in NOD mice.
Journal of autoimmunity. [PMID] 9480726.
1998
Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.
Nature. [PMID] 9428763.
1998
Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors.
Proceedings of the National Academy of Sciences of the United States of America. [PMID] 9826709.
1998
The relationship between humoral and cellular immunity to IA-2 in IDDM.
Diabetes. [PMID] 9568688.
1997
Antipolymer antibodies, silicone breast implants, and fibromyalgia.
Lancet (London, England). [PMID] 9113032.
1997
Cellular Immune Activities in Women with Silicone Breast Implants: A preliminary investigation
.
1997
Cellular immune reactivities in women with silicone breast implants: a preliminary investigation.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. [PMID] 9291420.
1997
Infants diets and insulin-dependent diabetes: evaluating the “cows’ milk hypothesis” and a role for anti-bovine serum albumin immunity.
Journal of the American College of Nutrition. [PMID] 9263182.
1997
Insulin-Dependent Diabetes Mellitus: the Hypothesis of Molecular Mimicry Between Islet Cell Antigens and Microorganisms
Molecular Medicine.
1997
Mechanisms underlying the loss of self tolerance in NOD mice.
Research in immunology. [PMID] 9352593.
1997
Mechanisms Underlying the Loss of Self-Tolerance in NOD Mice
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1997
Molecular mimicry and the pathogenesis of insulin-dependent diabetes mellitus: still just an attractive hypothesis.
Annals of medicine. [PMID] 9453286.
1997
NOD Mice as a Model for Inherited Deafness
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1997
Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta-cell antigens.
Diabetes. [PMID] 9392483.
1997
The Effect of Superantigen Administration on the Natural History of IDD in NOD Mice
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1997
The NOD mouse-Discussion
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1997
The Role of Infant Nutrition in the Pathogenesis of Insulin Dependent Diabetes
Food Technology.
1996
Early infant diets and insulin-dependent diabetes.
Lancet (London, England). [PMID] 8676633.
1996
Glutamic Acid Decarboxylase Autoantibodies in Stiff-Man Syndrome and Insulin Dependent Diabetes Mellitus Exhibit Similarities and Differences in Epitope Recognition
Journal of Immunology.
1996
Identification and characterization of glima 38, a glycosylated islet membrane antigen of 38KD, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes
Molecular Biology of the Cell.
1996
Identification and Characterization of Glima38, a Glycosylated Islet Cell Membrane Antigen, Which Together with GAD65 and IA2 Marks the Early Phases of Autoimmune Response inT 1 Diabetes
.
1996
Immunological and metabolic effects of prophylactic insulin therapy in the NOD-scid/scid adoptive transfer model of IDDM.
Diabetes. [PMID] 8549866.
1996
Modulating Autoimmune Responses to GAD Inhibits Disease Progression and Prolongs Islet Graft Survival in Diabetes-Prone Mice
.
1996
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice.
Nature medicine. [PMID] 8946834.
1996
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.
The Journal of experimental medicine. [PMID] 8666914.
1996
Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.
The Journal of pharmacology and experimental therapeutics. [PMID] 8930185.
1996
Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection.
Journal of immunology (Baltimore, Md. : 1950). [PMID] 8757636.
1996
The Clinical Significance of an Autoimmune Response against Glutamic Acid Decarboxylase
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1996
The clinical significance of an autoimmune response against glutamic acid decarboxylase.
Nature medicine. [PMID] 8574952.
1995
Clonal Diversion of T Cell Responses from Th1 to Th2: A Possible Mechanism of Diabetes Resistance in NOD-Ead Transgenic Mice
Autoimmunity.
1995
Cow’s Milk and IDDM: Only Time Will Tell
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1995
Detection of exocytosis at individual pancreatic beta cells by amperometry at a chemically modified microelectrode.
Proceedings of the National Academy of Sciences of the United States of America. [PMID] 7568182.
1994
Cellular Immunity to a Determinant Common to Glutamate Decarboxylase and Coxsackie Virus in Insulin Dependent Diabetes
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1994
Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.
The Journal of clinical investigation. [PMID] 7962558.
1994
GAD65 autoantibodies increase the predictability but not the sensitivity of islet cell and insulin autoantibodies for developing insulin dependent diabetes mellitus.
Journal of autoimmunity. [PMID] 7888042.
1994
Inverse Relation Between Humoral and Cellular Immunity to Glutamic Acid Decarboxylase in Subjects at Risk of Insulin-Dependent Diabetes
Journal of Endocrinological Investigation.
1994
Lack of Immunity to Bovine Serum Albumin in Insulin-Dependent Diabetes Mellitus. Authors Reply
New England Journal of Medicine.
1994
Prevention of Diabetes in the NOD Mouse: Implications for Therapeutic Intervention in Human Disease
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1994
Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease.
Immunology today. [PMID] 8172643.
1994
Should We Replace Islet Cell Antibody Assay For The Prediction of Insulin Dependent Diabetes
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1994
The pathogenesis of insulin-dependent diabetes mellitus.
The New England journal of medicine. [PMID] 7969282.
1994
The thymus as a site for evaluating the potency of candidate beta cell autoantigens in NOD mice.
Journal of autoimmunity. [PMID] 7888041.
1993
Amperometric monitoring of chemical secretions from individual pancreatic beta-cells.
Analytical chemistry. [PMID] 8368536.
1993
Amperometric Monitoring of individual Exocytosis events in pancreatic beta cells
Analytical chemistry.
1993
Association of 70 Kd molecule with HLA-DR of Rheumatic Fever Patients
ZENTRALBLATT FUR BAKTERIOLOGIE-SUPPLEMENT.
1993
Conformational Epitope Dependency for Islet Cell Cytoplasmic Autoantibodies (ICA) Reactive to Glutamate-Decarboxylase (GAD) in Insulin- Dependent Diabetes (IDD)
Diabetes.
1993
Early Diagnosis and Specific Treatment of Insulin-Dependent Diabetes
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1993
Early Diagnosis and Specific Treatment of Insulin-Dependent Diabetes
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1993
Early diagnosis and specific treatment of insulin-dependent diabetes.
Annals of the New York Academy of Sciences. [PMID] 8109841.
1993
Inverse Relation Between Humoral and Cellular Immunity to Glutamic Acid Decarboxylase in Subjects at Risk of Insulin-Dependent Diabetes
Lancet.
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Islet Cell Autoantigens in Insulin Dependent Diabetes
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1993
Islet cell autoantigens in insulin-dependent diabetes.
The Journal of clinical investigation. [PMID] 8408615.
1993
Islet Cell Cytoplasmic Autoantibody Reactivity to Glutamate Decarboxylase in Insulin-Dependent Diabetes
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1993
Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes.
The Journal of clinical investigation. [PMID] 8423231.
1993
Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes.
The New England journal of medicine. [PMID] 8247037.
1993
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.
Nature. [PMID] 7694152.
1992
Autoimmunity to Two Forms of Glutamate Decarboxylase in Insulin Dependent Diabetes Mellitus
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1992
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.
The Journal of clinical investigation. [PMID] 1370298.
1992
Is Insulin-Dependent Diabetes Mellitus Environmentally Induced?
New England Journal of Medicine.
1992
Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes.
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1991
GAD Autoimmunity in IDDM
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1991
No Evidence for Serological Autoimmunity To Islet Cell Heat Shock Proteins in Insulin Dependent Diabetes
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1991
No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes.
The Journal of clinical investigation. [PMID] 1991854.
1990
64,000 Mr autoantibodies as predictors of insulin-dependent diabetes.
Lancet (London, England). [PMID] 1971659.
1990
Comparison of islet autoantibodies in ‘pre-diabetes’ and recommendations for screening.
Journal of autoimmunity. [PMID] 2187460.
1990
Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy.
Diabetes. [PMID] 2197139.
1990
No Evidence for HSP 65 in Insulin Dependent Diabetes
Lancet.
1990
No Role for 65 kD Heat-Shock Protein in Diabetes
Lancet.
1990
The natural history and predictive value of Mr 64,000 autoantibodies for insulin-dependent diabetes mellitus.
Journal of autoimmunity. [PMID] 2187459.
1990
What causes diabetes?
Scientific American. [PMID] 2197720.
1988
Autoantibodies in nonobese diabetic mice immunoprecipitate 64,000-Mr islet antigen.
Diabetes. [PMID] 3053305.
1988
Dietary protein restriction reduces the frequency and delays the onset of insulin dependent diabetes in BB rats.
Autoimmunity. [PMID] 3155150.
1988
Enzymatic activity and filament assembly of Acanthamoeba myosin II are regulated by adjacent domains at the end of the tail.
FEBS letters. [PMID] 2968922.
1988
Inherited susceptibility to insulin-dependent diabetes is associated with HLA-DR1, while DR5 is protective.
Autoimmunity. [PMID] 2979618.
1988
Insulin autoantibodies in pre-diabetes.
Advances in experimental medicine and biology. [PMID] 3074667.
1987
Bovine Albumin Antibodies in NOD Mice
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1987
Bovine albumin antibodies in NOD mice.
Diabetes research (Edinburgh, Scotland). [PMID] 3427869.
1986
Are insulin autoantibodies markers for insulin-dependent diabetes mellitus?
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1986
Immune Response to Bovine Serum-Albumin (BSA) in NOD Mice – Possible Relevance to Diabetes
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1986
Insulin Autoantibodies As Markers For Insullin-Dependent Diabetes Mellitus (IDD)
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Grants

Aug 2022 ACTIVE
Biorepository and Coordinating Center for Studies on Cardiovascular Complications of Human Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2022 ACTIVE
Investigating type 1 diabetes pathogenesis using the live pancreas tissue slice platform.
Role: Other
Funding: NATL INST OF HLTH NIDDK
Feb 2022 ACTIVE
New way in delivering immunomodulatory drugs in T1D
Role: Principal Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL via NATL INST OF HLTH NIAID
Sep 2021 ACTIVE
Co-registration of Cell Organization, Phenotype and Function in the Human Pancreas During Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2021 ACTIVE
Experimental and natural SARS-CoV-2 infection of the human pancreas
Role: Principal Investigator
Funding: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI via NATL INST OF HLTH NIDDK
Aug 2021 ACTIVE
Human Pancreas Analysis Program (HPAP)
Role: Principal Investigator
Funding: UNIV OF PENNSYLVANIA via NATL INST OF HLTH NIDDK