GMS6622 Mitochondrial Biology in Aging and Disease
Areas of Interest
- Autoimmune Disease
- Immunology of Type 1 diabetes
Open Researcher and Contributor ID (ORCID)
Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines.
American journal of physiology. Regulatory, integrative and comparative physiology. 309(5):R525-34 [DOI] 10.1152/ajpregu.00544.2014. [PMID] 26084699.
Mitochondrial complex I activity is significantly decreased in a patient with maternally inherited type 2 diabetes mellitus and hypertrophic cardiomyopathy associated with mitochondrial DNA C3310T mutation: a cybrid study.
Diabetes research and clinical practice. 74(2):148-53 [PMID] 16828917.
Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis
Biochemical and Biophysical Research Communications. 277(2):281-286
Donor Eligibility Criteria and Pancreas Recovery for HuBMAP TMC-PNNL-UF v1
. [DOI] 10.17504/protocols.io.b7gurjww.
Donor Eligibility Criteria and Pancreas Recovery for HuBMAP TMC-PNNL-UF v2
. [DOI] 10.17504/protocols.io.b7nfrmbn.
Human Pancreas Processing v1
. [DOI] 10.17504/protocols.io.n2bvj6dnblk5/v1.
Feb 2020 ACTIVE
Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes
Funding: BATTELLE MEMORIAL INST via NATL INST OF HLTH NIDDK
Aug 2019 – Jul 2021
Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
Funding: NATL INST OF HLTH NIDDK
Jan 2019 – Jan 2022
The Role of IFN? supplementation in T cell effector function in Patients with Chronic Granulomatous Disease
Funding: UNIV OF SOUTH FLORIDA via HORIZON THERAPEUTICS
Jun 2018 ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Funding: NATL INST OF HLTH NIAID
Apr 2017 – Mar 2021
Advanced Liver 3-D Tissue Models for Drug Development Applications to Support Toxicology, Drug Metabolism, Target ID & Pharmacology
Funding: ADV REGENERATIVE MANUFACTURING INST via US ARMY RESEARCH LABORATORY
Jan 2015 – Aug 2018
Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
Funding: PACIFIC NW NATL LAB via NATL INST OF HLTH NIDDK