Jing Chen,
Associate Scientist
Department:
MD-PATHOLOGY-GENERAL
Business Phone:
(352) 273-9262
Business Email:
jic24@pathology.ufl.edu
Teaching Profile
Courses Taught
2021,2023-2024
GMS6622 Mitochondrial Biology in Aging and Disease
Research Profile
Areas of Interest
- Autoimmune Disease
- Diabetes
- Genetics
- Immunology of Type 1 diabetes
- Immunometabolism
Open Researcher and Contributor ID (ORCID)
0000-0001-8008-8062
Publications
2024
NADPH Oxidase 2–Derived Reactive Oxygen Species Promote CD8+ T Cell Effector Function
The Journal of Immunology.
212(2):258-270
[DOI] 10.4049/jimmunol.2200691.
[PMID] 38079221.
2024
Proteome-scale tissue mapping using mass spectrometry based on label-free and multiplexed workflows
Molecular & Cellular Proteomics.
[DOI] 10.1016/j.mcpro.2024.100841.
2023
Proteome mapping of the human pancreatic islet microenvironment reveals endocrine-exocrine signaling sphere of influence.
Molecular & cellular proteomics : MCP.
22(8)
[DOI] 10.1016/j.mcpro.2023.100592.
[PMID] 37328065.
2022
Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage.
Frontiers in genetics.
13
[DOI] 10.3389/fgene.2022.994501.
[PMID] 36276935.
2021
Mitochondrial haplogroup G is associated with nonalcoholic fatty liver disease, while haplogroup A mitigates the effects of PNPLA3
Endocrinology, Diabetes & Metabolism.
4(1)
[DOI] 10.1002/edm2.187.
[PMID] 33532620.
2021
Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes
Frontiers in Endocrinology.
12
[DOI] 10.3389/fendo.2021.737276.
[PMID] 34858326.
2019
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes
Frontiers in Immunology.
10
[DOI] 10.3389/fimmu.2019.00952.
[PMID] 31118934.
2018
ACTH-independent Cushing’s syndrome with bilateral cortisol-secreting adrenal adenomas: a case report and review of literatures.
BMC endocrine disorders.
18(1)
[DOI] 10.1186/s12902-018-0250-6.
[PMID] 29685132.
2018
Mitochondrial Reactive Oxygen Species and Type 1 Diabetes.
Antioxidants & redox signaling.
29(14):1361-1372
[DOI] 10.1089/ars.2017.7346.
[PMID] 29295631.
2018
Nanodroplet processing platform for deep and quantitative proteome profiling of 10–100 mammalian cells
Nature Communications.
9(1)
[DOI] 10.1038/s41467-018-03367-w.
[PMID] 29491378.
2018
Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of
Chemical science.
9(34):6944-6951
[DOI] 10.1039/c8sc02680g.
[PMID] 30210768.
2017
T cells display mitochondria hyperpolarization in human type 1 diabetes
Scientific Reports.
7(1)
[DOI] 10.1038/s41598-017-11056-9.
[PMID] 28883439.
2017
The Type 1 Diabetes–Resistance Locus Idd22 Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice
The Journal of Immunology.
199(12):3991-4000
[DOI] 10.4049/jimmunol.1602037.
[PMID] 29109122.
2015
Association of the mt-ND2 5178A/C polymorphism with Parkinson’s disease.
Neuroscience letters.
587:98-101
[DOI] 10.1016/j.neulet.2014.12.005.
[PMID] 25511548.
2015
Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines.
American journal of physiology. Regulatory, integrative and comparative physiology.
309(5):R525-34
[DOI] 10.1152/ajpregu.00544.2014.
[PMID] 26084699.
2015
Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells using Jurkat T lymphocyte Cells.
Journal of proteomics & bioinformatics.
8(6):126-132
[PMID] 26401069.
2015
Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver.
BMC biochemistry.
16
[DOI] 10.1186/s12858-015-0051-8.
[PMID] 26358560.
2014
Use of chemical probes to detect mitochondrial ROS by flow cytometry and spectrofluorometry.
Methods in enzymology.
542:223-41
[DOI] 10.1016/B978-0-12-416618-9.00012-1.
[PMID] 24862269.
2012
Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines.
European journal of clinical investigation.
42(11):1244-51
[DOI] 10.1111/j.1365-2362.2012.02711.x.
[PMID] 22924552.
2012
Oxidative stress and beta cell dysfunction.
Methods in molecular biology (Clifton, N.J.).
900:347-62
[DOI] 10.1007/978-1-60761-720-4_17.
[PMID] 22933078.
2011
mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic β-cell.
Diabetes.
60(1):355-9
[DOI] 10.2337/db10-1241.
[PMID] 20980458.
2011
Role of genetics in resistance to type 1 diabetes.
Diabetes/metabolism research and reviews.
27(8):849-53
[DOI] 10.1002/dmrr.1260.
[PMID] 22069272.
2011
Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.
PloS one.
6(6)
[DOI] 10.1371/journal.pone.0020617.
[PMID] 21738580.
2011
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.
Diabetes.
60(8):2144-51
[DOI] 10.2337/db10-1222.
[PMID] 21715554.
2009
Chapter 24 Quantification, localization, and tissue specificities of mouse mitochondrial reactive oxygen species production.
Methods in enzymology.
456:439-57
[DOI] 10.1016/S0076-6879(08)04424-8.
[PMID] 19348903.
2009
Rosiglitazone inhibits RANTES expression by human epidermal keratinocytes.
European journal of dermatology : EJD.
19(2):176-7
[DOI] 10.1684/ejd.2008.0591.
[PMID] 19106050.
2008
Commonalities of genetic resistance to spontaneous autoimmune and free radical–mediated diabetes
Free Radical Biology and Medicine.
45(9):1263-1270
[DOI] 10.1016/j.freeradbiomed.2008.07.020.
[PMID] 18718526.
2008
Role of increased ROS dissipation in prevention of T1D.
Annals of the New York Academy of Sciences.
1150:157-66
[DOI] 10.1196/annals.1447.045.
[PMID] 19120287.
2006
CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950).
177(5):2939-47
[PMID] 16920929.
2006
Mitochondrial complex I activity is significantly decreased in a patient with maternally inherited type 2 diabetes mellitus and hypertrophic cardiomyopathy associated with mitochondrial DNA C3310T mutation: a cybrid study.
Diabetes research and clinical practice.
74(2):148-53
[PMID] 16828917.
2006
Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis
Diabetes.
55:171-178
2006
Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950).
176(8):4590-9
[PMID] 16585549.
2005
“Agouti NOD”: identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells.
Mammalian genome : official journal of the International Mammalian Genome Society.
16(10):775-83
[PMID] 16261419.
2000
A patient with type 2 diabetes mellitus associated with mutations in calcium sensing receptor gene and mitochondrial DNA.
Biochemical and biophysical research communications.
278(3):808-13
[PMID] 11095989.
2000
Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis
Biochemical and Biophysical Research Communications.
277(2):281-286
Grants
Feb 2023
ACTIVE
Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Oct 2020
ACTIVE
Multi-omic 3D tissue maps for a Human BioMolecular Atlas
Role: Co-Investigator
Funding: PACIFIC NW NATL LAB
via NATL INST OF HLTH NIDDK
Feb 2020
– Jun 2024
Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes
Role: Faculty
Funding: BATTELLE MEMORIAL INST
via NATL INST OF HLTH NIDDK
Aug 2019
– Jul 2021
Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2019
– Jan 2022
The Role of IFN? supplementation in T cell effector function in Patients with Chronic Granulomatous Disease
Role: Co-Investigator
Funding: UNIV OF SOUTH FLORIDA
via HORIZON THERAPEUTICS
Jun 2018
– May 2023
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2017
– Mar 2021
Advanced Liver 3-D Tissue Models for Drug Development Applications to Support Toxicology, Drug Metabolism, Target ID & Pharmacology
Role: Faculty
Funding: ADV REGENERATIVE MANUFACTURING INST
via US ARMY RESEARCH LABORATORY
Jan 2015
– Aug 2018
Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
Role: Co-Investigator
Funding: PACIFIC NW NATL LAB
via NATL INST OF HLTH NIDDK
Contact Details
Phones:
- Business:
- (352) 273-9262
Emails:
- Business:
- jic24@pathology.ufl.edu
Addresses:
- Business Mailing:
-
1275 CENTER DR J587
GAINESVILLE FL 32610 - Business Street:
-
BIOMEDICAL SCIENCE BUILDING
BIOMEDICAL SCIENCE BUILDING
ROOM J587
GAINESVILLE FL 326100001