David A Ostrov

David A Ostrov,

Associate Professor

Department: MD-PATHOLOGY
Business Phone: (352) 273-8166
Business Email: ostroda@ufl.edu

Publications

2021
Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Journal of immunology (Baltimore, Md. : 1950). 206(6):1395-1404 [DOI] 10.4049/jimmunol.2000500. [PMID] 33547170.
2021
Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype.
The Journal of allergy and clinical immunology. 147(1):403-405 [DOI] 10.1016/j.jaci.2020.04.056. [PMID] 32439433.
2021
Emergence of porcine delta-coronavirus pathogenic infections among children in Haiti through independent zoonoses and convergent evolution.
medRxiv : the preprint server for health sciences. [DOI] 10.1101/2021.03.19.21253391. [PMID] 33791709.
2021
Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level.
Pathogens & immunity. 6(2):27-49 [DOI] 10.20411/pai.v6i2.460. [PMID] 34541432.
2021
Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2020.04.10.029454. [PMID] 33880475.
2021
HLA Class-II‒Restricted CD8+ T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients.
The Journal of investigative dermatology. 141(10):2412-2425.e2 [DOI] 10.1016/j.jid.2021.03.014. [PMID] 33798536.
2021
Human Leukocyte Antigen B*14:01 and B*35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury.
Hepatology (Baltimore, Md.). 73(1):268-281 [DOI] 10.1002/hep.31258. [PMID] 32270503.
2021
Identification and Characterization of Two Structurally Related Dipeptides that Enhance Catalytic Efficiency of Neurolysin.
The Journal of pharmacology and experimental therapeutics. 379(2):191-202 [DOI] 10.1124/jpet.121.000840. [PMID] 34389655.
2021
Identification of antiviral antihistamines for COVID-19 repurposing.
Biochemical and biophysical research communications. 538:173-179 [DOI] 10.1016/j.bbrc.2020.11.095. [PMID] 33309272.
2021
Structural Consequences of Variation in SARS-CoV-2 B.1.1.7.
Journal of cellular immunology. 3(2):103-108 [DOI] 10.33696/immunology.3.085. [PMID] 33969357.
2021
Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors.
Molecules (Basel, Switzerland). 26(4) [DOI] 10.3390/molecules26040983. [PMID] 33673320.
2021
The influence of selection bias on identifying an association between allergy medication use and SARS-CoV-2 infection.
EClinicalMedicine. 37 [DOI] 10.1016/j.eclinm.2021.100936. [PMID] 34104879.
2020
HLA-B*14:01 and HLA-B*35:01 are associated with trimethoprim-sulfamethoxazole induced liver injury.
Hepatology.
2020
Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency.
Biochemical and biophysical research communications. 527(1):317-323 [DOI] 10.1016/j.bbrc.2020.04.037. [PMID] 32446387.
2020
Multiple Recombination Events and Strong Purifying Selection at the Origin of SARS-CoV-2 Spike Glycoprotein Increased Correlated Dynamic Movements.
International journal of molecular sciences. 22(1) [DOI] 10.3390/ijms22010080. [PMID] 33374797.
2020
Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of Youth.
Diabetes. 69(5):954-964 [DOI] 10.2337/db19-1106. [PMID] 32139596.
2020
The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC.
PloS one. 15(1) [DOI] 10.1371/journal.pone.0226917. [PMID] 31929540.
2019
A Novel Small Molecule Inhibits Intrahepatocellular Accumulation of Z-Variant Alpha 1-Antitrypsin In Vitro and In Vivo.
Cells. 8(12) [DOI] 10.3390/cells8121586. [PMID] 31817705.
2019
Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01.
Allergy. 74(8):1533-1548 [DOI] 10.1111/all.13769. [PMID] 30844087.
2019
HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.
The Journal of allergy and clinical immunology. 144(1):183-192 [DOI] 10.1016/j.jaci.2019.01.045. [PMID] 30776417.
2019
Identification of drug-specific public TCR driving severe cutaneous adverse reactions.
Nature communications. 10(1) [DOI] 10.1038/s41467-019-11396-2. [PMID] 31395875.
2019
Interleukin-8 blockade prevents activated endothelial cell mediated proliferation and chemoresistance of acute myeloid leukemia.
Leukemia research. 84 [DOI] 10.1016/j.leukres.2019.106180. [PMID] 31299413.
2019
Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis.
Nature medicine. 25(4):690-700 [DOI] 10.1038/s41591-019-0393-7. [PMID] 30936544.
2019
Molecular docking predictions of fragrance binding to human leukocyte antigen molecules.
Contact dermatitis. 81(3):174-183 [DOI] 10.1111/cod.13283. [PMID] 30957232.
2019
Rationally designed small molecules to prevent type 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity. 26(2):90-95 [DOI] 10.1097/MED.0000000000000470. [PMID] 30694829.
2019
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Carbonic Anhydrase Inhibitors: Epidemiology, Genetics, and Insights into Mechanisms.
The journal of allergy and clinical immunology. In practice. 7(8):2854-2856 [DOI] 10.1016/j.jaip.2019.07.013. [PMID] 31706497.
2019
Targeting the site encoded by SERPINA1*E342K for treating alpha-1 antitrypsin deficiency-associated liver diseases.
FEBS letters. 593(14):1849-1862 [DOI] 10.1002/1873-3468.13452. [PMID] 31116417.
2018
Human Leukocyte Antigen Associations in Drug Hypersensitivity Reactions.
Clinics in laboratory medicine. 38(4):669-677 [DOI] 10.1016/j.cll.2018.08.002. [PMID] 30420060.
2018
Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.
The Journal of clinical investigation. 128(5):1888-1902 [DOI] 10.1172/JCI97739. [PMID] 29438107.
2018
Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors.
Cell adhesion & migration. 12(5):447-463 [DOI] 10.1080/19336918.2018.1471323. [PMID] 29781749.
2018
Severe Cutaneous Adverse Drug Reactions: Presentation, Risk Factors, and Management.
Current allergy and asthma reports. 18(4) [DOI] 10.1007/s11882-018-0778-6. [PMID] 29574562.
2018
SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.
The journal of allergy and clinical immunology. In practice. 6(1):38-69 [DOI] 10.1016/j.jaip.2017.11.023. [PMID] 29310768.
2018
The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine.
Journal of hepatology. 69(6):1317-1325 [DOI] 10.1016/j.jhep.2018.08.004. [PMID] 30138689.
2017
Association of the HLA-B*53:01 Allele With Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome During Treatment of HIV Infection With Raltegravir.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 64(9):1198-1203 [DOI] 10.1093/cid/cix096. [PMID] 28369189.
2017
Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B∗35:02 as a risk factor.
Journal of hepatology. 67(1):137-144 [DOI] 10.1016/j.jhep.2017.03.010. [PMID] 28323125.
2017
Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-08876-0. [PMID] 28819312.
2017
Structural Elements Recognized by Abacavir-Induced T Cells.
International journal of molecular sciences. 18(7) [DOI] 10.3390/ijms18071464. [PMID] 28686208.
2017
Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis.
International journal of oncology. 51(5):1370-1382 [DOI] 10.3892/ijo.2017.4131. [PMID] 29048609.
2016
Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection.
PloS one. 11(1) [DOI] 10.1371/journal.pone.0147230. [PMID] 26784987.
2016
Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.
Journal of diabetes research. 2016 [DOI] 10.1155/2016/6179635. [PMID] 26981544.
2015
Abacavir-reactive memory T cells are present in drug naïve individuals.
PloS one. 10(2) [DOI] 10.1371/journal.pone.0117160. [PMID] 25674793.
2015
Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity.
PloS one. 10(5) [DOI] 10.1371/journal.pone.0124878. [PMID] 26024233.
2015
Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.
Biochemistry. 54(2):422-33 [DOI] 10.1021/bi501088e. [PMID] 25513833.
2015
Development of novel Asf1-H3/H4 inhibitors.
Bioorganic & medicinal chemistry letters. 25(4):963-8 [DOI] 10.1016/j.bmcl.2014.11.067. [PMID] 25582598.
2015
Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.
Current diabetes reports. 15(11) [DOI] 10.1007/s11892-015-0656-8. [PMID] 26385483.
2015
HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping.
The Journal of allergy and clinical immunology. 135(1):253-9 [DOI] 10.1016/j.jaci.2014.07.047. [PMID] 25224099.
2015
Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry.
Journal of materials chemistry. B. 3(43):8492-8498 [DOI] 10.1039/c5tb00674k. [PMID] 32262689.
2015
Mimicking a Proline Tripeptide With Pyrazolidines and a Cyclopentane Linker
Tetrahedron Letters. 56(48):6653-6655 [DOI] 10.1016/j.tetlet.2015.09.063.
2015
New approaches for predicting T cell-mediated drug reactions: A role for inducible and potentially preventable autoimmunity.
The Journal of allergy and clinical immunology. 136(2):252-7 [DOI] 10.1016/j.jaci.2015.06.024. [PMID] 26254052.
2015
New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity.
The Journal of allergy and clinical immunology. 136(2):236-44 [DOI] 10.1016/j.jaci.2015.06.022. [PMID] 26254050.
2015
Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.
The Journal of allergy and clinical immunology. 136(2):262-71.e2 [DOI] 10.1016/j.jaci.2015.05.027. [PMID] 26254053.
2015
Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma.
Molecular cancer therapeutics. 14(1):80-9 [DOI] 10.1158/1535-7163.MCT-14-0229. [PMID] 25344582.
2015
T cell-mediated hypersensitivity reactions to drugs.
Annual review of medicine. 66:439-54 [DOI] 10.1146/annurev-med-050913-022745. [PMID] 25386935.
2014
A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors.
Autophagy. 10(11):2021-35 [DOI] 10.4161/auto.32229. [PMID] 25483883.
2014
Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo.
Breast cancer research and treatment. 145(1):45-59 [DOI] 10.1007/s10549-014-2940-8. [PMID] 24710637.
2014
Fever, rash, and systemic symptoms: understanding the role of virus and HLA in severe cutaneous drug allergy.
The journal of allergy and clinical immunology. In practice. 2(1):21-33 [DOI] 10.1016/j.jaip.2013.11.005. [PMID] 24565765.
2014
Gabapentin hybrid peptides and bioconjugates.
Bioorganic & medicinal chemistry. 22(4):1479-86 [DOI] 10.1016/j.bmc.2013.12.017. [PMID] 24468631.
2014
The effect of malnutrition on norovirus infection.
mBio. 5(2):e01032-13 [DOI] 10.1128/mBio.01032-13. [PMID] 24595373.
2013
A small-molecule inhibitor, 5′-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.
Anti-cancer agents in medicinal chemistry. 13(4):532-45 [PMID] 22292771.
View on: PubMed
2013
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.
BMC cancer. 13 [DOI] 10.1186/1471-2407-13-342. [PMID] 23841915.
2013
Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.
Blood. 121(12):2224-33 [DOI] 10.1182/blood-2012-10-460733. [PMID] 23325831.
2013
Gabapentin Hybrid Peptides and Bioconjugates Synthesis and Study of Their Interaction With Trpv1
. 245
2013
Identification of adenine nucleotide translocase 4 inhibitors by molecular docking.
Journal of molecular graphics & modelling. 45:173-9 [DOI] 10.1016/j.jmgm.2013.08.016. [PMID] 24056384.
2013
Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities.
Anti-cancer agents in medicinal chemistry. 13(4):546-54 [PMID] 22292772.
View on: PubMed
2013
Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.
Journal of medicinal chemistry. 56(3):1276-90 [DOI] 10.1021/jm3017305. [PMID] 23350733.
2012
A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.
Carcinogenesis. 33(5):1004-13 [DOI] 10.1093/carcin/bgs120. [PMID] 22402131.
2012
Characterization of the 8-Hydroxyquinoline Scaffold for Inhibitors of West Nile Virus Serine Protease
Antiviral Research. 94:18-24 [DOI] 10.1016/j.antivira1.2012.02.003.
2012
Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease.
Antiviral research. 94(1):18-24 [DOI] 10.1016/j.antiviral.2012.02.003. [PMID] 22343093.
2012
Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.
Cell cycle (Georgetown, Tex.). 11(17):3250-9 [DOI] 10.4161/cc.21611. [PMID] 22894899.
2012
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.
Proceedings of the National Academy of Sciences of the United States of America. 109(25):9959-64 [DOI] 10.1073/pnas.1207934109. [PMID] 22645359.
2012
Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.
The Journal of biological chemistry. 287(21):17894-17904 [DOI] 10.1074/jbc.M111.280511. [PMID] 22474295.
2012
Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family.
Genomics. 99(5):282-91 [DOI] 10.1016/j.ygeno.2012.02.004. [PMID] 22386706.
2012
Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.
Journal of clinical pharmacology. 52(6):837-49 [DOI] 10.1177/0091270011405664. [PMID] 21642471.
2012
Immunology. A decorated virus cannot hide.
Science (New York, N.Y.). 338(6108):748-9 [DOI] 10.1126/science.1230342. [PMID] 23139318.
2012
Islet autoantigens: structure, function, localization, and regulation.
Cold Spring Harbor perspectives in medicine. 2(8) [DOI] 10.1101/cshperspect.a007658. [PMID] 22908193.
2012
Kinetic characterization of newly discovered inhibitors of various constructs of human T-cell leukemia virus-1 (HTLV-1) protease and their effect on HTLV-1-infected cells.
Antiviral therapy. 17(5):883-92 [DOI] 10.3851/IMP2090. [PMID] 22436331.
2012
Novel Elastase Inhibitors From Marine Cyanobacteria: Structural Diversity, Target-Bound Crystal Structures and Cellular Effects
Planta Medica. 78
2012
Rational Identification of Enoxacin as a Novel V-Atpase-Directed Osteoclast Inhibitor
. 13:180-191
2012
Rational identification of enoxacin as a novel V-ATPase-directed osteoclast inhibitor.
Current protein & peptide science. 13(2):180-91 [PMID] 22044158.
View on: PubMed
2012
The structural basis of HLA-associated drug hypersensitivity syndromes.
Immunological reviews. 250(1):158-66 [DOI] 10.1111/j.1600-065X.2012.01163.x. [PMID] 23046128.
2011
A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells.
Journal of immunology (Baltimore, Md. : 1950). 186(7):4130-9 [DOI] 10.4049/jimmunol.1003512. [PMID] 21335485.
2011
A Novel Pkc-Iota Inhibitor Abrogates Cell Proliferation and Induces Apoptosis in Neuroblastoma (Vol 43, Pg 784, 2011)
International Journal of Biochemistry and Cell Biology. 43(9) [DOI] 10.1016/j.biocel.2011.05.015.
2011
A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma.
The international journal of biochemistry & cell biology. 43(5):784-94 [DOI] 10.1016/j.biocel.2011.02.002. [PMID] 21315177.
2011
A novel small molecule inhibitor of FAK and IGF-1R protein interactions decreases growth of human esophageal carcinoma.
Anti-cancer agents in medicinal chemistry. 11(7):629-37 [PMID] 21707510.
View on: PubMed
2011
Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3.
Acta crystallographica. Section F, Structural biology and crystallization communications. 67(Pt 2):221-3 [DOI] 10.1107/S1744309110050323. [PMID] 21301090.
2011
DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer.
PloS one. 6(2) [DOI] 10.1371/journal.pone.0016691. [PMID] 21311763.
2011
Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae.
PloS one. 6(4) [DOI] 10.1371/journal.pone.0019250. [PMID] 21532989.
2011
Molecular imaging of inflammation and carcinogenesis.
Cancer prevention research (Philadelphia, Pa.). 4(10):1523-6 [DOI] 10.1158/1940-6207.CAPR-11-0418. [PMID] 21972077.
2011
Prediction of off-target effects on angiotensin-converting enzyme 2.
Journal of biomolecular screening. 16(8):878-85 [DOI] 10.1177/1087057111413919. [PMID] 21859683.
2011
Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.
Journal of immunology (Baltimore, Md. : 1950). 187(11):5921-30 [DOI] 10.4049/jimmunol.1100746. [PMID] 22043012.
2010
A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts.
Molecular carcinogenesis. 49(2):200-9 [DOI] 10.1002/mc.20590. [PMID] 19885860.
2010
Novel Drug Targets To Overcome De Novo Drug-Resistance in Multiple Myeloma
Blood. 116
2010
Recognition of additional roles for immunoglobulin domains in immune function.
Seminars in immunology. 22(1):17-24 [DOI] 10.1016/j.smim.2009.11.006. [PMID] 20004115.
2010
Screening Small Molecule Inhibitors of Vla-5 To Block the Interaction Between Acute Lymphoblastic Leukemia With Ph Plus and Their Microenvironment
Blood. 116
2009
A novel class of cyclin-dependent kinase inhibitors identified by molecular docking act through a unique mechanism.
The Journal of biological chemistry. 284(43):29945-55 [DOI] 10.1074/jbc.M109.055251. [PMID] 19710018.
2009
A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.
Molecular cancer research : MCR. 7(12):1973-83 [DOI] 10.1158/1541-7786.MCR-09-0309. [PMID] 19996303.
2009
A Novel Small Molecule Inhibitor Decreases Growth of Human Pancreatic Cancer Xenografts
. 16
2009
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
Cell cycle (Georgetown, Tex.). 8(15):2435-43 [PMID] 19571674.
View on: PubMed
2009
Blocking a Topoisomerase II Alpha Nuclear Export Signal Sensitizes Human Multiple Myeloma Cells To Topoisomerase II Inhibitors.
Blood. 114
2009
Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.
American journal of respiratory and critical care medicine. 179(11):1048-54 [DOI] 10.1164/rccm.200811-1678OC. [PMID] 19246717.
2009
Expression of Jaz in Multiple Myeloma and Its Potential Role as a Novel Molecular Target
Blood. 114
2009
Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening.
Journal of medicinal chemistry. 52(16):5144-51 [DOI] 10.1021/jm900277z. [PMID] 19630402.
2009
Osteoclast polarization and orthodontic tooth movement.
Orthodontics & craniofacial research. 12(2):105-12 [DOI] 10.1111/j.1601-6343.2009.01443.x. [PMID] 19419453.
2009
Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.
Journal of medicinal chemistry. 52(15):4716-24 [DOI] 10.1021/jm900159g. [PMID] 19610651.
2009
Targeting of the protein interaction site between FAK and IGF-1R.
Biochemical and biophysical research communications. 388(2):301-5 [DOI] 10.1016/j.bbrc.2009.07.156. [PMID] 19664602.
2009
The Novel Fak Inhibitors Targeted To the Binding Site of Vegfr3 Inhibit Pancreatic Cancer Proliferation in Vitro and in Vivo
. 16
2008
A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition.
Immunity. 29(2):228-37 [DOI] 10.1016/j.immuni.2008.05.018. [PMID] 18674935.
2008
A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin.
Investigative ophthalmology & visual science. 49(7):3224-30 [DOI] 10.1167/iovs.07-1539. [PMID] 18378578.
2008
A Novel Small Molecule, Smil-1, Inhibits the Biological Effects of Vegfr-3 and Induces Apoptosis in Human Breast Cancer Cells
. 15
2008
A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.
Journal of medicinal chemistry. 51(23):7405-16 [DOI] 10.1021/jm800483v. [PMID] 18989950.
2008
Ace2 Activation Attenuates Monocrotatine-Induced Pulmonary Hypertension in Rats
Journal of Hypertension. 26
2008
Cardiovascular protection by angiotensin-converting enzyme 2: a new paradigm.
Future cardiology. 4(2):175-82 [DOI] 10.2217/14796678.4.2.175. [PMID] 19804294.
2008
Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group.
Acta crystallographica. Section F, Structural biology and crystallization communications. 64(Pt 6):564-6 [DOI] 10.1107/S1744309108011421. [PMID] 18540077.
2008
Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation.
Biochemistry. 47(32):8326-34 [DOI] 10.1021/bi800867d. [PMID] 18636744.
2008
Jaz “Targeting” Compounds Induce G1 Cell Cycle Arrest Followed By Cell Death in Human Leukemia Cells
Blood. 112
2008
Molecular modeling optimization of anticoagulant pyridine derivatives.
Journal of molecular graphics & modelling. 26(8):1365-9 [DOI] 10.1016/j.jmgm.2008.01.006. [PMID] 18372200.
2008
Novel Small Molecule Drugs That Target the Main Autophosphorylation Site (Y397) of Focal Adhesion Kinase Are Effective Cancer Therapeutics
. 15
2008
Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.
Hypertension (Dallas, Tex. : 1979). 51(5):1312-7 [DOI] 10.1161/HYPERTENSIONAHA.107.108944. [PMID] 18391097.
2008
Structure-Based Jaz Ligand-Ji and Its Analogues Show Strong Cytotoxic Effects On Glioma Cells in Vitro – a New Class of Glioma Therapy Drugs?
Journal of Neuropathology and Experimental Neurology. 67
2008
Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth.
Molecular cancer therapeutics. 7(8):2308-18 [DOI] 10.1158/1535-7163.MCT-08-0279. [PMID] 18723478.
2007
Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex.
Tissue antigens. 69(2):181-8 [PMID] 17257322.
View on: PubMed
2007
Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methods.
Acta crystallographica. Section F, Structural biology and crystallization communications. 63(Pt 12):1035-7 [PMID] 18084086.
View on: PubMed
2007
Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening.
Antimicrobial agents and chemotherapy. 51(10):3688-98 [PMID] 17682095.
View on: PubMed
2007
Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors.
Immunologic research. 38(1-3):294-304 [PMID] 17917037.
View on: PubMed
2007
The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.
Cellular signalling. 19(3):600-9 [PMID] 17027227.
View on: PubMed
2006
Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus.
Nature immunology. 7(8):875-82 [PMID] 16799561.
View on: PubMed
2005
Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation].
Journal of medicinal chemistry. 48(7):2526-33 [PMID] 15801842.
View on: PubMed
2004
Amsacta moorei entomopoxvirus expresses an active superoxide dismutase.
Journal of virology. 78(19):10265-75 [PMID] 15367592.
View on: PubMed
2004
Crystallization and preliminary X-ray analysis of VCBP3 from Branchiostoma floridae.
Acta crystallographica. Section D, Biological crystallography. 60(Pt 11):2022-4 [PMID] 15502315.
View on: PubMed
2004
Distinct footprints of TCR engagement with highly homologous ligands.
Journal of immunology (Baltimore, Md. : 1950). 172(12):7466-75 [PMID] 15187125.
View on: PubMed
2004
Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction.
Molecular and cellular biochemistry. 265(1-2):161-9 [PMID] 15543946.
View on: PubMed
2004
Mechanisms of antigen receptor evolution.
Seminars in immunology. 16(4):215-26 [PMID] 15522620.
View on: PubMed
2004
Resolution of the novel immune-type receptor gene cluster in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America. 101(44):15706-11 [PMID] 15496470.
View on: PubMed
2004
Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor.
Hypertension (Dallas, Tex. : 1979). 44(6):903-6 [PMID] 15492138.
View on: PubMed
2002
How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination.
Journal of immunology (Baltimore, Md. : 1950). 168(1):283-9 [PMID] 11751972.
View on: PubMed
2001
Immunobiological analysis of TCR single-chain transgenic mice reveals new possibilities for interaction between CDR3alpha and an antigenic peptide bound to MHC class I.
Journal of immunology (Baltimore, Md. : 1950). 167(8):4396-404 [PMID] 11591764.
View on: PubMed
2000
Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.
Journal of immunology (Baltimore, Md. : 1950). 165(8):4494-504 [PMID] 11035089.
View on: PubMed
2000
Structural features of MHC class I molecules that might facilitate alternative pathways of presentation.
Immunology today. 21(2):83-8 [PMID] 10652466.
View on: PubMed
2000
Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
Science (New York, N.Y.). 290(5492):816-9 [PMID] 11052947.
View on: PubMed
1993
T cell receptor antagonism mediated by interaction between T cell receptor junctional residues and peptide antigen analogues.
Journal of immunology (Baltimore, Md. : 1950). 150(10):4277-83 [PMID] 8482836.
View on: PubMed

Grants

Jul 2021 ACTIVE
Coordinating Center for the Drug Induced Liver Injury Network (DILIN)
Role: Principal Investigator
Funding: DUKE UNIVERSITY via NATL INST OF HLTH NIDDK
Jul 2020 – Jun 2021
Coordinating Center for the Drug Induced Liver Injury Network (DILIN)
Role: Principal Investigator
Funding: DUKE UNIVERSITY via NATL INST OF HLTH NIDDK
Jun 2020 ACTIVE
Development of Novel Cancer Drugs for the Treatment of Multiple Myeloma and Acute Myeloid Leukemia
Role: Principal Investigator
Funding: H LEE MOFFITT CANCER CTR via FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Oct 2019 – Oct 2020
Molecular modeling of HLA-B*39:01 interactions with infliximab
Role: Principal Investigator
Funding: TEN PEAKS
Apr 2019 ACTIVE
Mapping the T cell receptor/antigen complex and identifying the genetic-based treatment in Sjogrens syndrome
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Oct 2017 – Dec 2017
Molecular docking of small molecules to HLA molecules
Role: Principal Investigator
Funding: IMMUNOMOLECULAR THERAPEUTICS
Aug 2017 – Jan 2021
Identification of potent cross neutralizing Dengue antibodies using single-cell technology
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2017 ACTIVE
Enhancement of Biomarkers for Type 1 Diabetes
Role: Principal Investigator
Funding: BAYLOR COLLEGE OF MEDICINE via NATL INST OF HLTH NIDDK
Mar 2017 – Mar 2020
Identification of potent neutralizing Zika virus antibodies using single-cell analysis technology
Role: Co-Investigator
Funding: FL DEPT OF HLTH
Dec 2016 – Mar 2018
Testing Skin Sensitizers for Binding to HLA
Role: Principal Investigator
Funding: UT-BATTELLE via US DEPT OF ENERGY
Aug 2016 ACTIVE
Novel DNA damage response gene from genomic screening
Role: Co-Investigator
Funding: NATL INST OF HLTH NIEHS
May 2015 – Nov 2018
Novel small molecules for alpha-1 antitrypsin deficiency
Role: Principal Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Dec 2013 – Nov 2016
Targeting Histone Methylation for Triple-Negative Breast Cancer Therapy
Role: Project Manager
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Jul 2013 – Jun 2017
The Structural and Functional Basis of HLA-associated Drug Hypersensitivity
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2006 – Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS

Patents

Published September 2017
Long Acting Methyldopa for the Treatment of Type 1 Diabetes
#US2018/0116988
Published July 2017
Method of Treating Colorectal Cancer
#US2018/0008564
Issued April 2017
Compounds that Modulate Autoimmunity and Methods of Using the Same
#9,629,848
Issued April 2017
Topo II Inhibitor to Overcome De Novo Drug-Resistance in Multiple Myeloma
#9,616,051
Issued December 2016
Therapeutic Combinations for Use in Neoplasia
#9,517,244
Issued May 2016
ICA-1: A Novel PKC-Iota Inhibitor for the Treatment of Breast Cancer
#9,351,981
Issued April 2016
Method of Treating Ovarian Cancer Using a PKC Inhibitor
#9,301,965
Issued September 2015
Compositions and Methods of Treating Neoplasia
#9,144,596
Issued August 2014
Therapeutic Combinations for Use in Neoplasia
#8,815,828
Issued January 2014
Small Molecules that Target the Nuclear Export Signal of Topoisomerase II Alpha for the Treatment of Multiple Myeloma
#8,623,854
Issued October 2013
Cyclin Dependent Kinase Inhibitors
#8,569,356
Issued October 2013
Novel Compounds that Suppress the Autophagic Response
#8,545,841
Issued August 2013
Methods and Compositions for Treating Neoplasia
#8,501,242
Issued July 2013
PDK Inhibitor Compounds and Methods of Use Thereof
#8,492,344
Issued June 2013
Method of Selectively Inhibiting PKCiota
#8,461,192
Issued May 2013
Compounds and Methods for Treatment of Alpha-1 Antitrypsin Deficiency
#8,436,013
Issued March 2013
Kinase Protein Binding Inhibitors (CIP)
#8,404,669
Issued November 2012
Novel Small Molecule Drugs, Targeting The Main Autophosphorylation Site (Y397) of Focal Adhesion Kinase, As an Effective Cancer Therapy Approach
#8,314,150
Published April 2012
Method for Preventing Diabetes Targeting of Autoantigenic Trimolecular Complexes
#US 2012/0195929 A1
Published December 2011
Novel Small Molecule Drugs, Targeting the FAK and Mdm-2 Interaction, as an Effective Cancer Therapy Approach
#20120100227
Published November 2011
Novel Small Molecules that Target FAK and IGF-1R Receptor Protein Interactions
#20120107323-A1
Published October 2011
Novel V-ATPase-Directed Bone Anabolic Agents
#US-2012-0046246-A1
Published January 2011
Developing Novel Male Contraceptives and Anti-germ Cell Tumor Chemotherapeutics Using Small Compounds Selectively Inhibiting ANT4
#US-2011-0230564-A1
Published January 2009
Opsin Stabilizing Compounds and Methods of Use
#US2009-0286808

Teaching Profile

Courses Taught
2020-2021
GMS6001 Fundamentals of Biomedical Sciences I
2014-2015,2017-2021
GMS6065 Fundamentals of Cancer Biology
2017,2019-2021,2021
GMS6053 Cancer Biology and Therapeutics
2019
PHC7918 Independent Study
2018
MCB7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2014-2016,2021
GMS6140 Principles of Immunology
2014
GMS6029 Brain Journal Club
2021
GMS6009 Principles of Drug Action and Therapeutics

Contact Details

Phones:
Business:
(352) 273-8166
Emails:
Business:
ostroda@ufl.edu