Clive H Wasserfall

Clive H Wasserfall,

Assistant Professor

Department: MD-PATHOLOGY-GENERAL
Business Phone: (352) 273-9298
Business Email: clive@ufl.edu

About Clive H Wasserfall

Dr Clive Wasserfall trained in clinical laboratory medicine in South Africa prior to pursuing graduate studies in the USA (MS Clinical Chemistry) and Germany (PhD Immunology). My laboratory focus is on the immunopathogenesis of Type 1 Diabetes (T1D). Aspects of this work include refining prediction of disease onset/progression through the use of genetic, serologic and autoantibody assessment. The mechanism of disease is explored on the cellular and molecular level in order to better understand the pathogenesis of this disease and thereby lead to the goal of our program, which is to prevent T1D in those at risk. We are currently pursuing functional aspects of genotypes that either predispose or protect individuals from T1D. These genotypes having being identified by candidate gene or genome wide association studies tend to cluster around adaptive and innate immune pathways and our hypothesis is that the innate immune system provides a favorable milieu for the specific adaptive autoimmune attack on the insulin producing beta cells. The induction of immune tolerance to the insulin secreting endocrine pancreas is the current strategy being pursued for both primary intervention of disease, reversal of disease and/or to improve islet transplantation without the need for immunosuppression in those individuals that already have T1D. Additionally our laboratory is involved in immune monitoring of human clinical trails to reverse or prevent T1D while searching for biomarkers of efficacy. Our laboratory also houses the autoantibody screening core for the JDRF network for pancreas organ donors with diabetes (nPOD) program. http://www.jdrfnpod.org/

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-3522-8932

Areas of Interest
  • Autoimmune Disease
  • type 1 diabetes, pancreatic pathology, immune therapy, autoimmunity, clinical trials, translational research, emerging technologies, psychosocial behaviors, metabolism
  • vaccines

Publications

2021
Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes.
Diabetologia. [DOI] 10.1007/s00125-021-05501-8. [PMID] 34274990.
2021
Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Sudan.
Pediatric diabetes. 22(5):749-757 [DOI] 10.1111/pedi.13209. [PMID] 33837995.
2021
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.
Diabetes. 70(4):944-954 [DOI] 10.2337/db20-0995. [PMID] 33441381.
2021
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.
Diabetes. 70(4):932-943 [DOI] 10.2337/db20-0937. [PMID] 33419759.
2021
GRAS-microparticle microarrays identify dendritic cell tolerogenic marker-inducing formulations.
Lab on a chip. [DOI] 10.1039/d1lc00096a. [PMID] 34346460.
2021
Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas.
The American journal of pathology. 191(3):454-462 [DOI] 10.1016/j.ajpath.2020.11.010. [PMID] 33307036.
2021
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.
Diabetes. 70(5):1123-1129 [DOI] 10.2337/db20-1103. [PMID] 33632742.
2021
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes.
Diabetes. 70(8):1885-1897 [DOI] 10.2337/db21-0070. [PMID] 34035041.
2021
Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation.
Journal of immunology (Baltimore, Md. : 1950). 207(3):849-859 [DOI] 10.4049/jimmunol.2000708. [PMID] 34301848.
2021
Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes.
Diabetologia. 64(8):1822-1833 [DOI] 10.1007/s00125-021-05468-6. [PMID] 34003304.
2020
Assessing insulin sensitivity and resistance in syndromes of severe short stature.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 53-54 [DOI] 10.1016/j.ghir.2020.101339. [PMID] 32763832.
2020
Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics.
Metabolites. 10(9) [DOI] 10.3390/metabo10090350. [PMID] 32867274.
2020
Evaluation for type 1 diabetes associated autoantibodies in diabetic and non-diabetic Australian terriers and Samoyeds.
Canine medicine and genetics. 7(1) [DOI] 10.1186/s40575-020-00089-5. [PMID] 33323126.
2020
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association. 37(12):2160-2168 [DOI] 10.1111/dme.14361. [PMID] 32634859.
2020
Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.574447. [PMID] 33193362.
2020
Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.
Diabetes. 69(3):413-423 [DOI] 10.2337/db19-0942. [PMID] 31826866.
2020
Removing Formaldehyde-Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin-Fixed Paraffin-Embedded Tissues.
Angewandte Chemie (International ed. in English). 59(50):22584-22590 [DOI] 10.1002/anie.202008847.
2020
Removing Formaldehyde‐Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin‐Fixed Paraffin‐Embedded Tissues
Angewandte Chemie. 132(50):22773-22779 [DOI] 10.1002/ange.202008847.
2020
Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis.
Scientific reports. 10(1) [DOI] 10.1038/s41598-019-56951-5. [PMID] 31959869.
2020
Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues.
Diabetes. 69(1):60-66 [DOI] 10.2337/db19-0554. [PMID] 31597639.
2019
A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.
Cell metabolism. 29(3):755-768.e5 [DOI] 10.1016/j.cmet.2018.11.014. [PMID] 30713109.
2019
Clinical features, biochemistry and HLA-DRB1 status in children and adolescents with diabetes in Dhaka, Bangladesh.
Diabetes research and clinical practice. 158 [DOI] 10.1016/j.diabres.2019.107894. [PMID] 31669629.
2019
Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan
Diabetes Research and Clinical Practice. 149:9-17 [DOI] 10.1016/j.diabres.2019.01.023. [PMID] 30710658.
2019
Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.
ACS biomaterials science & engineering. 5(5):2631-2646 [DOI] 10.1021/acsbiomaterials.9b00332. [PMID] 31119191.
2019
Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.
Journal of clinical medicine. 8(9) [DOI] 10.3390/jcm8091321. [PMID] 31466263.
2019
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Nature. 574(7777):187-192 [DOI] 10.1038/s41586-019-1629-x. [PMID] 31597973.
2019
Untargeted metabolomic analysis in non-fasted diabetic dogs by UHPLC-HRMS.
Metabolomics : Official journal of the Metabolomic Society. 15(2) [DOI] 10.1007/s11306-019-1477-6. [PMID] 30830416.
2018
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-22574-5. [PMID] 29540798.
2018
Epidemiology of childhood-onset type 1 diabetes in Azerbaijan: Incidence, clinical features, biochemistry, and HLA-DRB1 status.
Diabetes research and clinical practice. 144:252-259 [DOI] 10.1016/j.diabres.2018.09.009. [PMID] 30218742.
2018
Hospital time prior to death and pancreas histopathology: implications for future studies.
Diabetologia. 61(4):954-958 [DOI] 10.1007/s00125-017-4494-x. [PMID] 29128936.
2018
Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes.
Diabetes. 67(10):2038-2053 [DOI] 10.2337/db17-1227. [PMID] 30065030.
2018
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.
Diabetes. 67(4):697-703 [DOI] 10.2337/db17-0937. [PMID] 29343548.
2017
Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?
Diabetes. 66(6):1443-1452 [DOI] 10.2337/db16-1551. [PMID] 28533295.
2017
Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.
Pancreas. 46(2):252-259 [DOI] 10.1097/MPA.0000000000000717. [PMID] 27984510.
2017
Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950). 198(11):4255-4267 [DOI] 10.4049/jimmunol.1700024. [PMID] 28461573.
2017
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes.
Diabetes care. 40(9):e122-e123 [DOI] 10.2337/dc17-0996. [PMID] 28679687.
2017
Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.00655. [PMID] 28659913.
2017
PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes.
Science translational medicine. 9(416) [DOI] 10.1126/scitranslmed.aam7543. [PMID] 29141886.
2017
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Cell metabolism. 26(3):568-575.e3 [DOI] 10.1016/j.cmet.2017.08.013. [PMID] 28877460.
2017
Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.
Scientific reports. 7 [DOI] 10.1038/srep42372. [PMID] 28205558.
2017
Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform.
Proceedings of the National Academy of Sciences of the United States of America. 114(38):10196-10201 [DOI] 10.1073/pnas.1711169114. [PMID] 28874568.
2017
Raising Awareness: The Need to Promote Allocation of Pancreata From Rare Nondiabetic Donors With Pancreatic Islet Autoimmunity to Type 1 Diabetes Research.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17(1):306-307 [DOI] 10.1111/ajt.13983. [PMID] 27460917.
2017
Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10-Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells.
Diabetes. 66(2):448-459 [DOI] 10.2337/db15-1625. [PMID] 28108611.
2017
Serum Trypsinogen Levels in Type 1 Diabetes.
Diabetes care. 40(4):577-582 [DOI] 10.2337/dc16-1774. [PMID] 28115475.
2017
Suppression of islet homeostasis protein thwarts diabetes mellitus progression.
Laboratory investigation; a journal of technical methods and pathology. 97(5):577-590 [DOI] 10.1038/labinvest.2017.15. [PMID] 28218739.
2017
Tracking the Antibody Immunome in Type 1 Diabetes Using Protein Arrays.
Journal of proteome research. 16(1):195-203 [DOI] 10.1021/acs.jproteome.6b00354. [PMID] 27690455.
2017
Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy.
Journal of immunology (Baltimore, Md. : 1950). 199(11):3757-3770 [DOI] 10.4049/jimmunol.1700822. [PMID] 29055002.
2017
Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-09908-5. [PMID] 28842637.
2016
A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.
Diabetes. 65(5):1310-6 [DOI] 10.2337/db15-0492. [PMID] 26718498.
2016
Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
Diabetes. 65(12):3765-3775 [PMID] 27669730.
View on: PubMed
2016
Autoimmune manifestations in aged mice arise from early-life immune dysregulation.
Science translational medicine. 8(361) [PMID] 27798262.
View on: PubMed
2016
Identification of tissue-specific cell death using methylation patterns of circulating DNA.
Proceedings of the National Academy of Sciences of the United States of America. 113(13):E1826-34 [DOI] 10.1073/pnas.1519286113. [PMID] 26976580.
2016
Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays.
Diabetes. 65(1):285-96 [DOI] 10.2337/db15-0179. [PMID] 26450993.
2016
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
Diabetes. 65(3):719-31 [DOI] 10.2337/db15-0779. [PMID] 26581594.
2016
Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes.
Clinical and experimental immunology. 183(3):350-7 [DOI] 10.1111/cei.12731. [PMID] 26462724.
2016
The influence of type 1 diabetes on pancreatic weight.
Diabetologia. 59(1):217-221 [DOI] 10.1007/s00125-015-3752-z. [PMID] 26358584.
2016
Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease.
Clinical and experimental immunology. 185(1):33-41 [DOI] 10.1111/cei.12797. [PMID] 27029857.
2015
A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.
Clinical immunology (Orlando, Fla.). 160(1):90-102 [DOI] 10.1016/j.clim.2015.03.023. [PMID] 25842187.
2015
A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.
Scientific reports. 5 [DOI] 10.1038/srep13155. [PMID] 26279095.
2015
Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.
Diabetes. 64(11):3885-90 [DOI] 10.2337/db15-0449. [PMID] 26216853.
2015
Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.
The Journal of clinical investigation. 125(1):448-55 [DOI] 10.1172/JCI78492. [PMID] 25500887.
2015
Antiviral antibody profiling by high-density protein arrays.
Proteomics. 15(12):2136-45 [DOI] 10.1002/pmic.201400612. [PMID] 25758251.
2015
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Diabetes. 64(11):3873-84 [DOI] 10.2337/db15-0164. [PMID] 26185279.
2015
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.
Genetics & epigenetics. 7:5-17 [DOI] 10.4137/GEG.S29696. [PMID] 26512207.
2015
Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia.
American journal of medical genetics. Part A. 167A(1):69-79 [DOI] 10.1002/ajmg.a.36810. [PMID] 25355237.
2015
Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigens.
Diabetes. 64(1):158-71 [DOI] 10.2337/db13-1639. [PMID] 25187361.
2014
B -Cell and T-Cell Interaction in Minimal Change Disease.
. 63(5)
2014
Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres.
Journal of materials chemistry. B. 2(17):2562-2574 [PMID] 24778809.
View on: PubMed
2014
Minimal change disease: a dysregulation of the podocyte CD80-CTLA-4 axis?
Pediatric nephrology (Berlin, Germany). 29(12):2333-40 [DOI] 10.1007/s00467-014-2874-8. [PMID] 25017621.
2014
Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development.
Diabetes. 63(10):3470-82 [DOI] 10.2337/db14-0213. [PMID] 24848066.
2014
Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice.
Diabetes. 63(8):2876-87 [DOI] 10.2337/db13-1236. [PMID] 24677716.
2014
The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.
Pediatric diabetes. 15(1):1-9 [DOI] 10.1111/pedi.12097. [PMID] 24325575.
2013
Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19(7):1126-9 [DOI] 10.1016/j.bbmt.2013.04.011. [PMID] 23611977.
2013
Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma.
Cancer immunology, immunotherapy : CII. 62(4):737-46 [DOI] 10.1007/s00262-012-1380-8. [PMID] 23223899.
2013
Increased complement activation in human type 1 diabetes pancreata.
Diabetes care. 36(11):3815-7 [DOI] 10.2337/dc13-0203. [PMID] 24041678.
2013
Influence of Tyrphostin AG490 on the expression of diabetes-associated markers in human adipocytes.
Immunogenetics. 65(1):83-90 [DOI] 10.1007/s00251-012-0659-4. [PMID] 23081744.
2013
Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function.
Diabetes. 62(8):2870-8 [DOI] 10.2337/db12-1619. [PMID] 23835340.
2013
Nardilysin-Dependent Proteolysis of Cell-Associated Vtcn1: a Novel Pathway and Biomarker of Type 1 Diabetes Development
Journal of Immunology. 190
2013
Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes.
PloS one. 8(10) [DOI] 10.1371/journal.pone.0076919. [PMID] 24204704.
2013
Serological autoantibody profiling of type 1 diabetes by protein arrays.
Journal of proteomics. 94:486-96 [DOI] 10.1016/j.jprot.2013.10.018. [PMID] 24148850.
2013
Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes.
Pediatric nephrology (Berlin, Germany). 28(9):1803-12 [DOI] 10.1007/s00467-013-2498-4. [PMID] 23689904.
2013
The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.
Journal of autoimmunity. 44:8-12 [DOI] 10.1016/j.jaut.2013.06.001. [PMID] 23891168.
2013
The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus.
Arthritis research & therapy. 15(2) [DOI] 10.1186/ar4208. [PMID] 23566364.
2013
Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice.
PloS one. 8(2) [DOI] 10.1371/journal.pone.0054712. [PMID] 23405091.
2012
Anti-Thymocyte Globulin (Atg) Differentially Depletes Naive and Memory T Cells and Permits Memory-Type Regulatory T Cells
Blood. 120
2012
Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.
BMC immunology. 13 [DOI] 10.1186/1471-2172-13-70. [PMID] 23237483.
2012
Central role for interleukin-2 in type 1 diabetes.
Diabetes. 61(1):14-22 [DOI] 10.2337/db11-1213. [PMID] 22187370.
2012
Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis.
American journal of physiology. Gastrointestinal and liver physiology. 302(3):G296-308 [DOI] 10.1152/ajpgi.00562.2010. [PMID] 22114116.
2012
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.
Diabetes/metabolism research and reviews. 28(7):608-17 [DOI] 10.1002/dmrr.2316. [PMID] 22585677.
2012
Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.
JAMA. 308(22):2337-9 [DOI] 10.1001/jama.2012.15008. [PMID] 23232891.
2012
Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.
The Journal of clinical investigation. 122(5):1717-25 [DOI] 10.1172/JCI60530. [PMID] 22484814.
2012
Serum levels of soluble CD25 as a marker for hepatocellular carcinoma.
Oncology letters. 4(4):840-846 [PMID] 23205111.
View on: PubMed
2012
The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice.
PloS one. 7(5) [DOI] 10.1371/journal.pone.0036079. [PMID] 22615750.
2012
The use of leptin as treatment for type 1 diabetes mellitus: counterpoint.
Pediatric diabetes. 13(1):74-6 [DOI] 10.1111/j.1399-5448.2011.00796.x. [PMID] 21884562.
2012
Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor.
Journal of clinical immunology. 32(5):1038-47 [DOI] 10.1007/s10875-012-9707-y. [PMID] 22661285.
2011
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
Journal of translational medicine. 9 [DOI] 10.1186/1479-5876-9-21. [PMID] 21345239.
2011
Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide.
Diabetes care. 34(12):2567-9 [DOI] 10.2337/dc11-1406. [PMID] 22011412.
2011
B cells enhance early innate immune responses during bacterial sepsis.
The Journal of experimental medicine. 208(8):1673-82 [DOI] 10.1084/jem.20101715. [PMID] 21746813.
2011
BCG vaccine-induced neuroprotection in a mouse model of Parkinson’s disease.
PloS one. 6(1) [DOI] 10.1371/journal.pone.0016610. [PMID] 21304945.
2011
Expression Profiling of Inflammatory Genes Identifies Differences in the Acute and Chronic Phases of Dss Induced Colitis
Inflammatory Bowel Diseases. 17
2011
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.
PloS one. 6(10) [DOI] 10.1371/journal.pone.0025792. [PMID] 22043294.
2011
Immune Modulation in Early Onset Pompe Disease
Molecular Genetics and Metabolism. 102(2):S31-S32 [DOI] 10.1016/j.ymgme.2010.11.107.
2011
Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.
Journal of immunology (Baltimore, Md. : 1950). 186(6):3538-46 [DOI] 10.4049/jimmunol.1001864. [PMID] 21317395.
2011
Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies.
Diabetes. 60(11):2914-21 [DOI] 10.2337/db11-0705. [PMID] 21926271.
2011
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.
Diabetes. 60(8):2086-91 [DOI] 10.2337/db11-0373. [PMID] 21659497.
2011
Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.
Diabetes. 60(10):2566-70 [DOI] 10.2337/db11-0576. [PMID] 21844098.
2011
The threshold hypothesis: solving the equation of nurture vs nature in type 1 diabetes.
Diabetologia. 54(9):2232-6 [DOI] 10.1007/s00125-011-2244-z. [PMID] 21773685.
2011
Toward defining the autoimmune microbiome for type 1 diabetes.
The ISME journal. 5(1):82-91 [DOI] 10.1038/ismej.2010.92. [PMID] 20613793.
2010
Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
Journal of pediatric gastroenterology and nutrition. 51(4):414-7 [DOI] 10.1097/MPG.0b013e3181dd913a. [PMID] 20706153.
2010
Dimorphic histopathology of long-standing childhood-onset diabetes.
Diabetologia. 53(4):690-8 [DOI] 10.1007/s00125-009-1642-y. [PMID] 20062967.
2010
Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.
Journal of diabetes and its complications. 24(3):163-7 [DOI] 10.1016/j.jdiacomp.2008.12.004. [PMID] 19217320.
2010
Hepatocellular carcinoma immunopathogenesis: clinical evidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25).
Digestive diseases and sciences. 55(2):484-95 [DOI] 10.1007/s10620-009-0955-5. [PMID] 19714465.
2010
Influence of serum and soluble CD25 (sCD25) on regulatory and effector T-cell function in hepatocellular carcinoma.
Scandinavian journal of immunology. 72(4):293-301 [DOI] 10.1111/j.1365-3083.2010.02427.x. [PMID] 20883314.
2010
Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Diabetologia. 53(10):2198-204 [DOI] 10.1007/s00125-010-1829-2. [PMID] 20593162.
2010
Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
PloS one. 5(5) [DOI] 10.1371/journal.pone.0010507. [PMID] 20463897.
2010
The combined effects on neuronal activation and blood-brain barrier permeability of time and n-3 polyunsaturated fatty acids in mice, as measured in vivo using MEMRI.
NeuroImage. 50(4):1384-91 [DOI] 10.1016/j.neuroimage.2010.01.057. [PMID] 20097292.
2009
Amelioration of Insulitis and Reversal of Diabetes in Nod Mice By Murine Anti-Thymocyte Globulin and Granulocyte-Colony Stimulating Factor Combination Therapy
Clinical Immunology. 131:S48-S49 [DOI] 10.1016/j.clim.2009.03.137.
2009
Anti-Mouse Thymocyte Globulin Administration Alters Dendritic Cell Profile and Function in Nod Mice To Suppress Diabetogenic Responses.
American Journal of Transplantation. 9
2009
Autologous umbilical cord blood transfusion in very young children with type 1 diabetes.
Diabetes care. 32(11):2041-6 [DOI] 10.2337/dc09-0967. [PMID] 19875605.
2009
Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model.
The ISME journal. 3(5):536-48 [DOI] 10.1038/ismej.2009.5. [PMID] 19225551.
2009
Gastrointestinal Directed Adeno-Associated Virus Serotype 9 and 10 Expressing Il-10 Improves Enterocolitis in a Murine Model of Inflammatory Bowel Disease
Molecular Therapy. 17
2009
Gene therapy approaches to induce tolerance in autoimmunity by reshaping the immune system.
Current opinion in investigational drugs (London, England : 2000). 10(11):1143-50 [PMID] 19876782.
View on: PubMed
2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes. 58(10):2277-84 [DOI] 10.2337/db09-0557. [PMID] 19628781.
2009
Influence of fecal sample storage on bacterial community diversity.
The open microbiology journal. 3:40-6 [DOI] 10.2174/1874285800903010040. [PMID] 19440250.
2009
Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
PloS one. 4(11) [DOI] 10.1371/journal.pone.0007980. [PMID] 19956753.
2009
Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation.
Pediatric research. 65(3):311-6 [DOI] 10.1203/PDR.0b013e3181961e80. [PMID] 19047917.
2009
Network for Pancreatic Organ Donors With Diabetes (Npod): Donor Demographics and Early Progress Report
Hormone Research. 72:156-157
2009
Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.
Diabetologia. 52(2):262-70 [DOI] 10.1007/s00125-008-1200-z. [PMID] 19002428.
2009
Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
Journal of immunology (Baltimore, Md. : 1950). 182(8):4608-15 [DOI] 10.4049/jimmunol.0713269. [PMID] 19342635.
2009
T regulatory cell function in idiopathic minimal lesion nephrotic syndrome.
Pediatric nephrology (Berlin, Germany). 24(9):1691-8 [DOI] 10.1007/s00467-009-1214-x. [PMID] 19495805.
2009
Taking a daily vitamin to prevent type 1 diabetes?
Diabetes. 58(1):24-5 [DOI] 10.2337/db08-1479. [PMID] 19114727.
2009
Urinary CD80 excretion increases in idiopathic minimal-change disease.
Journal of the American Society of Nephrology : JASN. 20(2):260-6 [DOI] 10.1681/ASN.2007080836. [PMID] 19056875.
2009
Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment.
Diabetes care. 32(11):1977-9 [DOI] 10.2337/dc09-1089. [PMID] 19675194.
2008
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Clinical immunology (Orlando, Fla.). 126(3):303-14 [PMID] 18096436.
View on: PubMed
2008
Alpha-1 antitrypsin treatment of spontaneously diabetic nonobese diabetic mice receiving islet allografts.
Transplantation proceedings. 40(2):457-8 [DOI] 10.1016/j.transproceed.2008.02.010. [PMID] 18374100.
2008
Alterations in Mucosal Cytokine Levels Reflect Acute Inflammation But Not Chronic Inflammation in the Murine Dss Model of Colitis
Inflammatory Bowel Diseases. 14
2008
Autologous umbilical cord blood infusion for type 1 diabetes.
Experimental hematology. 36(6):710-5 [DOI] 10.1016/j.exphem.2008.01.009. [PMID] 18358588.
2008
CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.
Cytokine. 44(1):154-9 [DOI] 10.1016/j.cyto.2008.07.468. [PMID] 18778952.
2008
Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice.
Diabetes. 57(12):3281-8 [DOI] 10.2337/db08-0688. [PMID] 18835930.
2008
Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
Annals of the New York Academy of Sciences. 1150:152-6 [DOI] 10.1196/annals.1447.049. [PMID] 19120286.
2008
Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice.
Clinical and experimental immunology. 154(1):15-21 [DOI] 10.1111/j.1365-2249.2008.03721.x. [PMID] 18759852.
2008
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes. 57(2):405-14 [PMID] 18039815.
View on: PubMed
2008
Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.
Pediatric research. 63(3):303-7 [PMID] 18091354.
View on: PubMed
2008
Prolonged islet allograft survival by alpha-1 antitrypsin: the role of humoral immunity.
Transplantation proceedings. 40(2):455-6 [DOI] 10.1016/j.transproceed.2008.02.009. [PMID] 18374099.
2008
Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.
The American journal of pathology. 173(1):154-60 [DOI] 10.2353/ajpath.2008.070963. [PMID] 18511516.
2007
Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7(5):1112-20 [PMID] 17456199.
View on: PubMed
2007
Alpha1-antitrypsin protects beta-cells from apoptosis.
Diabetes. 56(5):1316-23 [PMID] 17360983.
View on: PubMed
2007
Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11.
Immunology. 122(1):1-14 [PMID] 17662044.
View on: PubMed
2007
Comment on: Brugman S et al. (2006) Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia 49:2105-2108.
Diabetologia. 50(1):220-1 [PMID] 17119915.
View on: PubMed
2007
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Annals of the New York Academy of Sciences. 1103:90-3 [PMID] 17376822.
View on: PubMed
2007
Impact of resistant starch on body fat patterning and central appetite regulation.
PloS one. 2(12) [PMID] 18074032.
View on: PubMed
2007
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes.
Diabetes. 56(3):604-12 [PMID] 17327427.
View on: PubMed
2007
Novel synthesis of cerium oxide nanoparticles for free radical scavenging.
Nanomedicine (London, England). 2(3):325-32 [PMID] 17716177.
View on: PubMed
2006
A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome.
Pediatric nephrology (Berlin, Germany). 21(5):603-10 [PMID] 16525836.
View on: PubMed
2006
Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
Human gene therapy. 17(6):625-34 [PMID] 16776571.
View on: PubMed
2006
Autoantibody markers for the diagnosis and prediction of type 1 diabetes.
Autoimmunity reviews. 5(6):424-8 [PMID] 16890898.
View on: PubMed
2006
Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
Diabetes. 55(7):1939-45 [PMID] 16804061.
View on: PubMed
2006
Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice.
Laboratory investigation; a journal of technical methods and pathology. 86(2):130-40 [PMID] 16424881.
View on: PubMed
2006
Freeze-thaw increases adeno-associated virus transduction of cells.
American journal of physiology. Cell physiology. 291(2):C386-92 [PMID] 16510845.
View on: PubMed
2006
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.
Diabetes. 55(1):171-8 [PMID] 16380490.
View on: PubMed
2006
PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).
Gene. 369:134-41 [PMID] 16412588.
View on: PubMed
2005
An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950). 174(9):5181-6 [PMID] 15843512.
View on: PubMed
2005
Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Neurology. 64(4):743-5 [PMID] 15728308.
View on: PubMed
2005
Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice.
Brain research. 1041(2):223-30 [PMID] 15829231.
View on: PubMed
2005
Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.
Journal of virology. 79(2):1045-52 [PMID] 15613333.
View on: PubMed
2005
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
Diabetes. 54(5):1407-14 [PMID] 15855327.
View on: PubMed
2005
Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice.
FEBS letters. 579(25):5759-64 [PMID] 16223491.
View on: PubMed
2005
High frequency of abnormal glucose tolerance in DQA1*0102/DQB1*0602 relatives identified as part of the Diabetes Prevention Trial–Type 1 Diabetes.
Diabetologia. 48(1):68-74 [PMID] 15602651.
View on: PubMed
2005
Impact of humoral immune response on distribution and efficacy of recombinant adeno-associated virus-derived acid alpha-glucosidase in a model of glycogen storage disease type II.
Human gene therapy. 16(1):68-80 [PMID] 15703490.
View on: PubMed
2005
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America. 102(20):7251-6 [PMID] 15878989.
View on: PubMed
2005
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis.
Diabetes. 54(9):2525-32 [PMID] 16123339.
View on: PubMed
2005
Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.
Transplantation. 80(4):530-3 [PMID] 16123729.
View on: PubMed
2004
Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes.
Diabetes care. 27(8):2010-4 [PMID] 15277432.
View on: PubMed
2004
Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.
The American journal of pathology. 165(3):1045-53 [PMID] 15331427.
View on: PubMed
2004
Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity.
Gene therapy. 11(3):233-40 [PMID] 14737082.
View on: PubMed
2004
Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes.
Diabetes care. 27(12):2911-7 [PMID] 15562206.
View on: PubMed
2004
Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice.
Gene therapy. 11(2):181-6 [PMID] 14712302.
View on: PubMed
2003
Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
Pediatric diabetes. 4(1):10-8 [PMID] 14655518.
View on: PubMed
2003
Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.
Diabetes. 52(3):708-16 [PMID] 12606512.
View on: PubMed
2003
Neurobehavioral changes resulting from recombinase activation gene 1 deletion.
Clinical and diagnostic laboratory immunology. 10(1):13-8 [PMID] 12522033.
View on: PubMed
2003
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950). 171(5):2270-8 [PMID] 12928371.
View on: PubMed
2003
The second murine autoantibody workshop: remarkable interlaboratory concordance for radiobinding assays to identify insulin autoantibodies in nonobese diabetic mice.
Annals of the New York Academy of Sciences. 1005:1-12 [PMID] 14679035.
View on: PubMed
2002
Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.
Transplantation. 74(8):1184-6 [PMID] 12438968.
View on: PubMed
2001
Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America. 98(24):13913-8 [PMID] 11717448.
View on: PubMed
2001
Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors.
Diabetes. 50(3):515-20 [PMID] 11246870.
View on: PubMed
2000
Glutamic acid decarboxylase and IA-2 autoantibodies in type 1 diabetes: comparing sample substrates for autoantibody determinations.
Pediatric diabetes. 1(1):10-6 [PMID] 15016237.
View on: PubMed
1999
Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.
The Journal of clinical investigation. 104(4):515-23 [PMID] 10449443.
View on: PubMed
1999
Association of diabetes mellitus and chronic hepatitis C virus infection.
Hepatology (Baltimore, Md.). 29(2):328-33 [PMID] 9918906.
View on: PubMed
1999
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America. 96(14):8116-9 [PMID] 10393957.
View on: PubMed
1998
Respiratory health and immunological profile of poultry workers.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 88(9):1110-7 [PMID] 9798499.
View on: PubMed
1998
The relationship between humoral and cellular immunity to IA-2 in IDDM.
Diabetes. 47(4):566-9 [PMID] 9568688.
View on: PubMed
1997
Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta.
Proceedings of the Association of American Physicians. 109(4):429-39 [PMID] 9220540.
View on: PubMed
1997
Effect of oral and intravenous insulin and glutamic acid decarboxylase in NOD mice.
Autoimmunity. 26(3):139-51 [PMID] 9550282.
View on: PubMed
1997
Immunization therapies in the prevention of diabetes.
Journal of autoimmunity. 10(3):287-92 [PMID] 9218756.
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1997
Prediction and prevention of IDDM.
Diabetologia. 40 Suppl 3:B58-61 [PMID] 9345647.
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1996
Antigen based therapies to prevent diabetes in NOD mice.
Journal of autoimmunity. 9(3):349-56 [PMID] 8816970.
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1996
IA-2 and IA-2 beta are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments.
Journal of autoimmunity. 9(5):677-82 [PMID] 8933284.
View on: PubMed
1996
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America. 93(13):6367-70 [PMID] 8692821.
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1993
A survey of a small group of workers exposed to toluene di-isocyanate.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 83(2):100-3 [PMID] 8383881.
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Grants

Sep 2021 ACTIVE
Natural History and Mechanisms of Exocrine Pancreatic Dysfunction in Pre-Type 1 Diabetes
Role: Other
Funding: NATL INST OF HLTH NIDDK
Aug 2021 ACTIVE
Human Pancreas Analysis Program (HPAP)
Role: Co-Investigator
Funding: UNIV OF PENNSYLVANIA via NATL INST OF HLTH NIDDK
May 2021 ACTIVE
The Network for Pancreatic Organ donors with Diabetes (nPOD) : A Collaborative Type 1 Diabetes Research Project
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Sep 2020 ACTIVE
Type 1 Diabetes in Acute Pancreatitis Consortium – Clinical Centers
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Aug 2020 – Jul 2021
Targeted nanodelivery in T1D
Role: Co-Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL via NATL INST OF HLTH NIAID
Feb 2020 ACTIVE
T1D Exchange Biobank Transfer
Role: Principal Investigator
Funding: JDRF
Feb 2020 ACTIVE
Human Atlas of Neonatal Developmental and Early Life Pancreas / Immunity (HANDEL)-P/I Continuation
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Sep 2019 ACTIVE
Evaluation of safety, tolerability and immunological responses to Lactobacillus johnsonii N6.2 supplementation in adults with Diabetes type 1
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2019 – Jun 2021
In situ analysis of functional endocrine, vascular, and immune cell interactions during early postnatal development of the human pancreas
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER via NATL INST OF HLTH NIDDK
Apr 2019 – Mar 2020
A Composite Serological Risk Score to Predict Type 1 Diabetes Progression and Clinical Diagnosis
Role: Principal Investigator
Funding: JDRF
Sep 2018 – Aug 2021
Identification of Anti-Neo-Antigen AutoAntibodies in Type 1 Diabetes
Role: Co-Investigator
Funding: ARIZONA STATE UNIVERSITY via NATL INST OF HLTH NIDDK
Sep 2018 ACTIVE
A 3D Tissue Map of the Human Lymphatic System
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2018 ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2018 – Mar 2021
Collaborative Type 1 Diabetes Research Project: The Network for Pancreatic Organ donors with Diabetes (nPOD)
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jun 2017 – Nov 2018
Circadian Rhythmicity of Innate and Adaptive Immunity in T1D
Role: Principal Investigator
Funding: WESTERN MICHIGAN UNIVERSITY via JDRF
Dec 2016 – Dec 2018
Pharmacological modulation of stem cells for immunotherapy in autoimmune diabetes
Role: Principal Investigator
Funding: FATE THERAPEUTICS
Oct 2015 – Aug 2016
Inhibition of Gut Microbial Polysaccharide Metabolism as a Novel Potential Therapeutic for the Prevention of Autoimmunity Associated with Type-1 Diabetes
Role: Principal Investigator
Funding: CLEMSON UNIV via JDRF
Jul 2014 – Jun 2019
Biomaterial Delivery System for Type 1 Diabetes Vaccine
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK

Patents

Issued July 2018
Materials and Methods for Modulating Immune Responses
#10,022,440
Published July 2018
Materials and Methods for Modulating Immune Responses
#US-2018-0311344-A1
Published January 2016
Type 1 Diabetes Biomarkers
#US-2016-0195546-A1
Issued November 2013
Biomarkers for Diferentiating Between type 1 and Type II Diabetes
#8,594,949
Issued January 2010
Biomarkers for Differentiating Between Type 1 and Type 2 Diabetes
#7,648,825
Published January 2010
Biomarkers for Differentiating Between Type 1 and Type 2 Diabetes
#US-2010-012629-A1
Published July 2009
Materials and Methods For The Detection, Prevention and Treatment of Autoimmune Disease
#US-2010-0178652-A1
Published May 2008
Materials and Methods for Reversing Type I Diabetes
#US-2009-0162345-A1

Education

PhD Immunology
2019 · Technical University Dresden
MS Clinical Chemistry
1998 · University of Florida

Teaching Profile

Courses Taught
2020-2021
PHA6613 Clinical Applications Precision Medicine: Precision Health
2019
EGN4912 Engineering Directed Independent Research
2019
HSC4905 Individual Study
2018
BMS6300 Fund Micro and Immuno
2014-2016,2021
GMS6140 Principles of Immunology

Contact Details

Phones:
Business:
(352) 273-9298
Emails:
Business:
clive@ufl.edu
Administrative Asst:
Linda S Harlan
View Profile